Dr. Tami Martino
Heart Failure, Circadian Rhythms, Molecular Biology of Heart Disease, Translational Research, Cardiovascular Physiology, Proteomics of Heart Disease
B.Sc - McMaster University
MSc, PhD - University of Toronto
Research Institutes worked at
Hospital for Sick Children Toronto; Toronto General Hospital; MARS Discovery
Canadian Fund for Innovation (CFI) Infrastructure Grant - PI
Canadian Institute of Health Research Operating Grant (CIHR) - PI
Heart and Stroke Foundation of Ontario, Operating Grants - PI
Ontario Cancer Biomarker Network - Co-applicant with G. Bjarnason
Department of Medicine Mimi and Charles Hollenberg Research Competition Award
Heart and Stroke Foundation of Ontario,
Research Fellowship Award
Canadian Institutes of Health Research (CIHR), Strategic Training Initiative in Cardiovascular Health Research (TACTICS), Research Fellowship Award
Circadian regulation of cardiac growth and remodeling in cardiovascular diseases such as myocardial infarction (heart attacks), hypertension, cardiac hypertrophy.
Circadian dyssynchrony and its important role in human health - sleep disorders, shift work
Day/night or circadian variation in physiologic and molecular processes, and its unique relevance to biomarker discovery and molecular diagnostics.
State-of-the-art high throughput technologies including microarrays, mass spectrometry proteomics, and bioinformatics.
Cardiovascular transgenic laboratory
Cardiovascular physiology suite: cardiovascular disease models, echocardiography, hemodynamics, pathology, immunohistochemistry
Circadian rhythms laboratory: Colbourn actigraphy, diurnal dyssynchrony, circadian mutant mice, chronotherapy models of heart disease, chronobiomarkers
Proteomics: 2D dige, mass spectrometry, BioRad ChemiDoc Imaging System, BioRad 1D gel apparatus
Flow cytometry, Accuri C6
Molecular genomics: microarrays, RTPCR Viia7 Machine, spectrophotometer Nanodrop, genotyping facilities
Media and Links
Departmental Faculty Page
Simple changes in ICU can help heart attack patients: Study
Sun News Article: "Proper sleep speeds up recovery after heart attack: Study"
Guelph News Article: "Tick Tock Goes the Heart"
Guelph News Article: "Heart Medication Best at Bedtime"
CTV Media Report: The most effective time of day to take medication
The Globe and Mail Article: "Your heart medication is more effective at bedtime"
Guelph News Article: "U of G collaborations look for the causes of cardiovascular disease"
Experimental Biology 2011 Article
Guelph News Article: "Watch Your Circadian Clock to Help Your Ticker"
Peter Podobed, PhD Student, (Graduated F'14)
Elena Tsimakouridze, PhD Student, (2010- present)
Faisal Alibhai, PhD Student, (2011 - present)
Cristine Reitz, PhD Student, (2014 - present)
Brittany King, Undergraduate 4th year project (2014-2015)
Craig Hilborn, Undergraduate student (Summer 2015)
Allison Mackay, Technician, (2009 - present)
Shawn Hutchinson, Undergraduate 4th year project (2012)
Nirmala Chinnappareddy, Postdoc (2009-2012)
Heather Chin, Undergraduate student (Summer 2011)
Michael Bennardo (Graduated S'10)
Robyn Goldstein, Undergraduate 4th year project (2013 - 2014)
Publications (since 2000)
28. Martino TA, Young ME. (2015)
Influence of the Cardiomyocyte Circadian Clock on Cardiac Physiology and Pathophysiology.
J Biol Rhythms. [Epub ahead of print]
27. Tsimakouridze EV, Alibhai FJ, Martino TA. (2015).
Therapeutic applications of circadian rhythms for the cardiovascular system.
Front. Pharmacol. 6:77. Published online March 26, 2015.
26. Alibhai FJ, Tsimakourdize EV, Reitz CJ, Pyle G, Martino TA. (2015).
Consequences of Circadian and Sleep Disturbances for the Cardiovascular System
Canadian Journal of Cardiology. Published online January 26, 2015.
25. Young ME, Brewer RA, Peliciari-Garcia RA, Collins HE, He L, Birky TL, Peden BW, Thompson EG, Ammons BJ, Bray MS, Chatham JC, Wende AR, Yang Q, Chow CW, Martino TA, Gamble KL. (2014)
Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heart.
J Biol Rhythms. Aug;29(4):257-76.
24. Podobed PS, Alibhai FJ, Chow CW, Martino TA. (2014).
Circadian regulation of myocardial sarcomeric Titin-cap (Tcap, telethonin): identification of cardiac clock-controlled genes using open access bioinformatics data.
PLoS One. 2014 Aug 14;9(8):e104907.
23. Podobed P, Pyle WG, Ackloo S, Alibhai FJ, Tsimakouridze EV, Ratcliffe WF, Mackay A, Simpson JA, Wright DC, Kirby G, Young ME, Martino TA. (2014).
The Day/Night Proteome in the Murine Heart.
Am J Physiol Regul Integr Comp Physiol. 2014 Jul 15;307(2):R121-37.
22. Alibhai FJ, Tsimakouridze EV, Reitz CJ, Pyle WG, Martino TA. (2014). 'The Cardiac Clock' in the Role of the Circadian Clock in Health and Disease. Springer APS. In Press.
21. Alibhai FJ, Tsimakouridze EV, Chinnappareddy N, Wright DC, Billia F, O'Sullivan L, Pyle WG, Sole MJ, Martino TA. (2014).
Short Term Disruption of Diurnal Rhythms Following Murine Myocardial Infarction Adversely Affects Long Term Myocardial Structure and Function.
Circulation Research. 2014 May 23;114(11):1713-22.
20.- Editorial Focus by Sharma UC and Canty JM Jr. (2014).
Myocardial repair around-the-clock.
Commentary on Alibhai F.J. et al.,Short Term Disruption of Diurnal Rhythms Following Murine Myocardial Infarction Adversely Affects Long Term Myocardial Structure and Function. Circ Res. 2014 May 23;114(11):1713-22. (see above)
19. Tsimakouridze EV, Straume M, Podobed PS, Chin H, Lamarre J, Johnson R, Antenos M, Kirby GM, Mackay A, Huether P, Simpson JA, Sole M, Gadal G, Martino TA. (2012).
Chronomics of pressure overload-induced cardiac hypertrophy in mice reveals altered day/night gene expression and biomarkers of heart disease.
Chronobiology International 29: pp. 810-821.
18. Podobed P, Kirby G, Martino T.A. (2012). Circadian proteomics and its unique advantage for discovery of biomarkers of heart disease. In TK Man, RJ Flores (Eds.) "Proteomics. Human Diseases and Protein Functions", pp. 65-88. InTech.
17. Martino T.A., et al. (2011). The Primary Benefits of Angiotensin Converting Enzyme Inhibition on Cardiac Remodelling Occur During Sleep-Time in Murine Pressure Overload Hypertrophy. Journal of the American College of Cardiology, May17;57(20):2020-2028.
16.- Editorial Focus by Jugdutt BI (2011). Optimizing Pharmacotherapy for Limiting Cardiovascular Remodeling. A Matter of Timing Therapy to Match Biology. Editorial Commentary on Martino T.A. et al., The Primary Benefits of ACE Inhibition, J Am Coll Cardiol, 2011;57:2029-30 (see above).
15. M.J. Sole and Martino, T.A. (2010). Diurnal Molecular Rhythms: Unrecognized Critical Determinants of Cardiovascular Health and Disease. In T.D. Bradley and J.S. Floras (Eds.) Sleep Apnea: Implications in Cardiovascular and Cerebrovascular Disease. Chapter 1. Pages 1-14.
14. Martino T.A., and Sole M.J. (2009). Molecular Time. An Often Overlooked Dimension to Cardiovascular Disease. Circulation Research. Invited Review. Nov 20;105(11):1047-1061.
13. - Editorial Focus by Karyn A. Esser and Martin E. Young (2009) on Highlighted Topic, The Role of Clock Genes in Cardiometabolic Disease. J. Appl. Physiol. 107:1316-1317.
12. Sole M.J., and Martino T.A. (2009). Diurnal Physiology: Core Principles with Application to the Pathogenesis, Diagnosis, Prevention and Treatment of Myocardial Hypertrophy and Failure. Journal of Applied Physiology. Invited Review. 2009, Oct;107(4):1318-27, Epub 2009 Jun 25.
11. Chalmers J.A., Martino T.A., Tata N, Ralph M.R., Sole M.J., Belsham D.D. (2008). Vascular circadian rhythms in a mouse vascular smooth muscle cell line (Movas-1). American Journal of Physiology- Regulatory Integrative and Comparative Physiology, 2008 Nov;295(5):R1529-1538. Epub 2008 Sept 3.
10. Chalmers J.A., Lin SYJ, Martino T.A., Arab S, Liu Peter, Husain M, Sole M.J., Belsham D.D. (2008). Diurnal Profiling of NeuroEndocrine Genes in Murine Heart and Shift in Proopriomelanocortin Gene Expression with Pressure-Overload Cardiac Hypertrophy. Journal of Molecular Endocrinology, 2008 Sept;41(3):117-124. Epub 2008 June 12.
9. Martino T.A, Oudit GY, Herzenberg AM, Tata N, Koletar MM, Kabir GM, Belsham DD, Backx PH, Ralph, MR, and Sole MJ. (2008). Circadian Rhythm Disorganization Produces Profound Cardiovascular and Renal Disease in Hamsters. American Journal of Physiology- Regulatory Integrative and Comparative Physiology, 2008 May;294(5):1675-1683. Epub 2008 Feb 13.
8. - Editorial Focus by Fred W. Turek (2008) on "Circadian Rhythm Disorganization Produces Profound Cardiovascular and Renal Disease in Hamsters: by Martino et al. Am. J. Physiol. Regul. Integr. Comp. Physiol 2008 May;294(5):1672-4. Epub 2008 Mar 19
7. Martino, T.A., Tata N., Bjarnason G.A., Straume M., and Sole M.J. (2007). Diurnal Protein Expression in Blood Revealed by High Throughput Mass Spectrometry Proteomics, and Implications for Translational Medicine and Body-Time-Of-Day (BTOD). American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Sep;293(3):1430-7. Epub Jun 6.
6. Martino, T.A., Tata N, Belsham DD, Straume M, Lee, P, Chalmers J, Pribiag H, Khaper N, Liu PP, Dawood F, Backx PH, Ralph MR, and Sole MJ. (2007). Disturbed Diurnal Rhythm Alters Gene Expression and Exacerbates Cardiovascular Disease with Rescue by Resynchronization. Hypertension, May;49(5):1104-13. Epub Mar 5.
5. Martino T, S. Arab, M. Straume, DD. Belsham, N. Tata, F. Cai, P. Liu, M. Trivieri, M. Ralph, MJ. Sole (2004). Day/night rhythms in gene expression of the normal murine heart. Journal of Molecular Medicine, 86:256-264.
4. Ayach B, Fuse K, Martino T, P. Liu (2003). Dissecting mechanisms of innate and acquired immunity in myocarditis. Current Opinion in Cardiology, 18:175-181.
3. Opavsky, M.A., T. Martino, M. Rabinovitch, C. Richardson, M. Petric, C. Trinidad, J. Penninger, and P. Liu. (2002). The extracellular signal-regulated kinase signaling cascade is a key determinant of susceptibility to coxsackievirus B3 infection and myocarditis in mice. Journal of Clinical Investigation, 109:1561-1569.
2. Martino, T.A., M. Petric, H. Weingartl, J. M. Bergelson, M. A. Opavsky, C. D. Richardson, J. F. Modlin, R. W. Finberg, K. C. Kain, N. Willis, C. J. Gauntt, and P. P. Liu. (2000). The coxsackievirus-adenovirus receptor (CAR) is used by reference strains and clinical isolates representing all six serotypes of coxsackievirus group B and by swine vesicular disease virus. Virology, 271, 99-108.
1. Liu, P., K. Aitken, Y. Y. Kong, M. A. Opavsky, T. Martino, F. Dawood, W. H. Wen, I. Kozieradzki, K. Bachmaier, D. Straus, T. W. Mak, and J.M. Penninger. (2000). The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nature Medicine, 6, 429-434.