Dr. Todd Gillis
Research Platforms:
Molecular Biology of Heart Disease, Cardiovascular Physiology, Embryonic Development of Cardiac Function

Academic Background:
B.Sc - Guelph 1994
M.Sc - Guelph 1996
Ph.D - Simon Fraser University 2002
Post-Doctoral Fellow, Department of Bioengineering, University of Washington 2002-2005

Awards:
Scholander Award for Young Researcher, American Physiological Society
Simon Fraser University Dean of Graduate Studies Convocation Medal
William S Hoar Award, Canadian Society of Zoology
NSERC Post Doctoral Fellowship

Research Interests:
Role of the contractile element in regulating functional capability of the heart
Evolution of the regulatory control of cardiac contractile function
Remodeling of the vertebrate heart in response to physiological stressors

Projects Recently Completed:
Role of Protein Kinase A in the regulation of cardiac function in lower vertebrates
The ontogony of the cardiac adrenergic response during embryonic development in trout

Projects in Progress:
Changes in the cardiac proteome and contractile function during cold induced cardiac hypertrophy in trout
TnT isoform switching during cardiac development
Regulatory mechanism of cardiac remodeling

Facilities/Unique Equipment:
Aurora Scientific muscle mechanics instrument
Stoped flow spectrofluorometer
Perkin Elmer spectrofuorometor
GE ÄKTA FPLCT
GE Ettan 2D Gel Electrophoresis system

Funding:
NSERC, CIHR, Canadian Foundation for Innovation, American Heart Foundation

Links:
Cardiac Protein Lab Page
Departmental Faculty Page

Students:
Jordan Klaiman
Kelly Kirkpatrick (M.Sc)
Silvana Miller (M.Sc)

Publications:
1. Miller, S.C., Gillis, T.E., and Wright, P.A. The ontogeny of regulatory control of the rainbow trout (Oncorhynchus mykiss) heart and how this is influenced by chronic hypoxia exposure Journal of Experimental Biology. 214, 1989-1996 (2011).
2. Kirkpatrick, K.P., Robertson, A.S., Klaiman, J., & Gillis, T.E. The influence of trout cardiac troponin I and PKA phosphorylation on the Ca2+ affinity of the cardiac troponin complex. Journal of Experimental Biology. 214, 1981-1988 (2011).
3. Gillis, T.E., & Klaiman J., The influence of PKA phosphorylation on the Ca2+ activation of force generation by trout cardiac muscle. Journal of Experimental Biology. 214, 2065-2072 (2011).
4. Gillis, T.E. Evolution of the regulatory control of vertebrate striated muscle: The roles of troponin I and myosin binding protein-C. Physiological Genomics. 42:406-19 (2010).
5. Miller S.C, Reeb S.E, Wright P.A., and Gillis, TE. The influence of dissolved oxygen and water flow rate on growth and metabolic rate of rainbow trout embryos. Canadian Journal of Fisheries and Aquatic Sciences. 85:2170-77 (2008)
6. Liang, B., Chung, F., Qu, Y., Gillis, T.E., Tikunova, S.B., Davis, J.P. and G.F. Tibbits. The Familial Hypertrophic Cardiomyopathy related cardiac troponin C mutation, L29Q affects Ca2+ binding and myofilament contractility. Physiological Genomics. 33:257-66. (2008).
7. Gillis, T.E.,, Marshall, C.R, and G. F. Tibbits. Functional and Evolutionary Relationships of Troponin C. Physiological Genomics. 32:16-27 (2007).
8. Gillis, T.E., Martyn, D.A., Rivera, A.J. & Regnier, M. Investigation of thin filament near-neighbor regulatory unit interactions during skinned rat cardiac muscle force development. Journal of Physiology. 580:561-76. (2007).
9. Kreutziger KL, Gillis T.E., Davis JP, Tikunova SB, and Regnier M. Influence of enhanced troponin C Ca2+ binding affinity on cooperative thin filament activation in skeletal muscle. Journal of Physiology. 583:337-50. (2007)
10. Moreno-Gonzalez, A., Gillis, T.E., Rivera, A.J., Chase, P.B., Martyn, D.A. & Regnier, M. (2007). Thin filament regulation of force redevelopment kinetics in rabbit skeletal muscle fibres. Journal of Physiology. 579:313-26. (2007).
11. Gillis, T.E. , Liang, B., Chung, F., & Tibbits, G.F. Increasing mammalian cardiomyocyte contractility with residues identified in trout troponin C. Physiological Genomics . 22:1-7 (2005)
12. Blumenschein, T.M.A., Gillis, T.E. , Tibbits, G.F. & Sykes, B.D. Effect of temperature on the structure of trout cardiac troponin C. Biochemistry . 43:4955-4963 (2004).
13. Gillis, T.E ., Blumenschein, T.M.A., Sykes, B.D. & Tibbits, G.F. The effect of temperature and the F27W mutation on the Ca-activated structural transition of trout cardiac troponin C. Biochemistry . 42:6418-6426 (2003).
14. Gillis, T.E ., Moyes, C.D., & Tibbits, G.F. Sequence mutations in teleost cardiac troponin C that are permissive of high site II Ca 2+ affinity. American Journal of Physiology: Cell Physiology . 284, C1176-1184 (2003).
15. Gillis,T.E., & Tibbits, G.F. Beating the cold: The functional evolution of troponin C in teleost fish. (Invited Review). Comparative Biochemistry and Physiology Part A Molecular and Integrative Physiology 132, 763-772 (2002).
16. Gillis, T.E .,Marshall , C.R., Xue, X.H., Borgford, T.J., &Tibbits, G.F. Ca 2+ binding to cardiac troponin C: effects of temperature and pH on mammalian and salmonid isoforms. American Journal of Physiology:
Regulatory, Integrative, and Comparative Physiology . 279, R1707-R1715 (2000).
17. Gillis, T.E ., & Ballantyne, J.S. Mitochondrial membrane composition of two Arctic Marine bivalves mollusks, Serripes groenlandicus and Mya truncata . Lipids . 34, 53-57 (1999).
18. Gillis, T.E ., & Ballantyne, J.S. Influences of sub-zero thermal acclimation on mitochondrial membrane composition of temperate marine bivalve mollusks. Lipids . 34, 59-66 (1999).
19. Stuart, J.S., Gillis, T.E. , & Ballantyne, J.S. Compositional correlates of metabolic depression in mitochondrial membrane of an estivating snail, Cepaea nemoralis . American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology. 275, R1977-R1982 (1998).
20. Stuart, J.S., Gillis, T.E. , & Ballantyne, J.S. Remodeling of phospholipid fatty acids in mitochondrial membranes of an estivating snail. Lipids . 33, 787-793 (1998).
21. Gillis, T.E. , & Ballantyne, J.S. Effects of starvation on plasma free amino acids and glucose concentrations in Lake Sturgeon , Acipenser fulvescens . Journal of Fish Biology . 49, 1306-1316 (1996).
22. Leblanc, P.J., Gillis, T.E. , Gerrits, M.F., & Ballanatyne, J.S. Metabolic organization of liver and somatic muscle of landlocked sea lamprey, Petromyzon marinus , during spawning migration. Canadian Journal of Zoology . 73, 916-923 (1995).