Elena Tsimakouridze
Supervisor: Dr. Tami Martino

Program: PhD, Department of Biomedical Sciences, University of Guelph (2012-Present) MSc, Department of Biomedical Sciences, University of Guelph (2010-Reclassified to PhD)

Academic Background:
Honours Bachelor of Science (2009): Double major in Human Biology and Animal Physiology; Minor in General Anthropology; 4th Year Research Project: Circadian Rhythms.

Awards:
Canadian Society for Chronobiology, Merit-based Travel Award for the Second Conference of CSC: May 2015
Betty Goldhart Biomedical Sciences Scholarship, OVC: April 2015
Novartis Cardiology Graduate Scholarship: April 2014
OVC PhD Scholarship, University of Guelph, Department of Biomedical Sciences:May 2012
PhD Entrance award, University of Guelph, Department of Biomedical Sciences:September 2012
PhD Poster Award - York University: May 2012
MSc Entrance award- University of Guelph, Department of Biomedical Sciences:September 2011
PhD Poster Award - York University: May 2012
CIHR Travel Award 2011

Research Interests:
Circadian rhythms have a profound, but often overlooked impact on human health and treatment. I use bioinformatics tools to identify differential gene expression in heart disease vs. healthy heart over 24 h. This allowed for the discovery of several diurnal genetic and protein biomarkers for cardiovascular disease which eventually can be used to create clinical point-of-care tests for cardiac patients. To-date, I am responsible for the murine cardiovascular surgical suite, where I solely perform the myocardial infrction and hemodynamic sergeries. Currently, I am looking to determine whether commonly prescribed cardiovascular drugs vary in eficacy with slep time vs. wake time administration after a heart attack in a murine model. I also maintain my academic Chronotherapy blog .

Thesis Topic:
Applications of Circadian Rhythms in Translational Medicine; Chronootherapy and Diurnal Biomarkers for Cardiovascular Disease

Publications:
7. Basu P, Alibhai FJ, Tsimakouridze EV, Singh RK, Paglialunga S, Holloway GP, Martino TA, Bakovic M. (2015). Male-specific cardiac dysfunction in CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) deficient mice. Mol Cell Biol. 2015 May 18. [Epub ahead of print]. PMID: 25986609

6. Alibhai FJ, Tsimakouridze EV, Reitz CJ, Pyle WG, Martino TA. The Role of the Circadian Clock in Health and Disease. Springer APS. 2015, In Press.

5. Tsimakouridze EV, Alibhai FJ, Martino TA. (2015). Therapeutic applications of circadian rhythms for the cardiovascular system. Front. Pharmacol. 2015 Apr 17;6:77. PMID: 25941487

- Editorial Feature: Yang G, Wang H, Zhang E. Editorial: Therapeutic implications of circadian rhythms. (2015). Front Pharmacol. 2015; 6: 175. PMC4541160

4. Alibhai F, Tsimakourdize E, Reitz C, Pyle G, Martino TA. (2015). Consequences of Circadian and Sleep Disturbances for the Cardiovascular System Canadian Journal of Cardiology. Can J Cardiol. 2015 Jan 26. Epub ahead of print]. PMID: 26031297

3. Podobed PS, Pyle WG, Ackloo S, Alibhai FJ, Tsimakouridze EV, Ratcliffe W, Mackay A, Simpson JA, Kirby G, Young ME, Martino TA. The Day/Night Proteome in the Murine Heart. Am J Physiol Regul Integr Comp Physiol. 2014 Jul 15;307(2):R121-37. PMID: 24789993

2. Alibhai FJ, Tsimakouridze EV, Chinnappareddy N, Wright DC, Billia F, O'Sullivan ML, Pyle WG, Sole MJ, Martino TA. Short term disruption of diurnal rhythms following murine myocardial infarction adversely affects long term myocardial structure and function. Circ Res. May 23, 2014;114(11):1713-22. PMID: 24687134

1. Tsimakouridze EV, Straume M, Podobed PS, Chin H, Lamarre J, Johnson R, Antenos M, Kirby GM, Mackay A, Huether P, Simpson JA, Sole M, Gadal G, Martino TA. (2012). Chronomics of pressure overload-induced cardiac hypertrophy in mice reveals altered day/night gene expression and biomarkers of heart disease. Chronobiology International 29: pp. 810-821. PMID: 22823865

Conferences Attended (selected):
Second Conference for the Canadian Society for Chronobiology, Montreal, QC (May 29-31, 2015)
First Conference for the Canadian Society for Chronobiology, Toronto, Ontario (May, 2013)
33rd International Society of Heart Research, North American Section Meeting: Pathology and Treatment of Heart Failure, Banff, Alberta (2012)
3rd Annual Muscle Health Research Awareness Day, York University (2012), Received one of two PhD presentation awards.
Heart Failure: Thinking Beyond Traditional Management Strategies, University of Western Ontario (2011)
6th Annual Canadian Genetic Epidemiology & Statistical Genetics Meeting (2011)
Graduate Student Research Symposium (2010)

Abstracts:
1. EV Tsimakouridze, PS Podobed, MR Bennardo, MJ Sole, M Straume, TA Martino. Diurnal Rhythms in Gene Expression as Critical Determinants of Cardiovascular Disease; A Novel Platform for Biomarker Discovery. Graduate Student Research Symposium, Univ. of Guelph, Nov. 17, 2010.

2. EV Tsimakouridze, PS Podobed, A Mackay, H Chin, J Simpson, P Huether, M Antenos, J LaMarre, R Johnson, M Straume, M Sole, TA Martino. Circadian Genetic and Protein Biomarkers of Cardiovascular Disease. Graduate Student Research Symposium, Univ. of Guelph. Nov. 16, 2011.

3. EV Tsimakouridze, PS Podobed, MR Bennardo, J Lamarre, R Johnson, MJ Sole, M Straume, TA Martino. Diurnal Rhythms in Gene Expression as Critical Determinants of Cardiovascular Disease; A Novel Platform for Biomarker Discovery. 6th Annual Canadian Genetic Epidemiology & Statistical Genetics Meeting, King City, ON. May 11-13, 2011.

4. EV Tsimakouridze, PS Podobed, MR Bennardo, J Lamarre, R Johnson, MJ Sole, M Straume, TA Martino. Diurnal Rhythms in Gene Expression as Critical Determinants of Cardiovascular Disease; A Novel Platform for Biomarker Discovery. Heart Failure: Thinking Beyond Traditional Management Strategies, Univ. of Western Ontario. Jun. 8, 2011.

5. EV Tsimakouridze, M Straume, PS Podobed, H Chin, J LaMarre, R Johnson, M Antenos, GM Kirby, A Mackay, P Huether, G Gadal, J Simpson, MJ Sole, TA Martino. The Mammalian Chronome Reveals Novel Biomarkers of Heart Disease in Pressure Overload Induced Cardiac Hypertrophy in Mice. 3rd Annual Muscle Health Research Awareness Day, York Univ. May 25, 2012. Awarded one of two PhD awards.

6. EV Tsimakouridze, M Straume, PS Podobed, H Chin, J LaMarre, R Johnson, M Antenos, GM Kirby, A Mackay, P Huether, G Gadal, J Simpson, MJ Sole, TA Martino. The Mammalian Chronome Reveals Novel Biomarkers of Heart Disease in Pressure Overload Induced Cardiac Hypertrophy in Mice. 33rd International Society for Heart Research, North American Section Meeting: Pathology and Treatment of Heart Failure. Banff, AB. May 28-31, 2012.

7. EV Tsimakouridze, M Straume, PS Podobed, H Chin, J LaMarre, R Johnson, M Antenos, GM Kirby, A Mackay, P Huether, G Gadal, J Simpson, MJ Sole, TA Martino. First Conference for the Canadian Society for Chronobiology, Toronto, Ontario, May 24-26, 2013.

8. Lorenzen-Schmidt L, Tsimakouridze EV, Alibhai FJ, Martino TA, Pyle WG. Crossing the Line: A Decrease in the Z-line Protein Cap-Z Worsens Function after Ischemia-Reperfusion Injury. 35th Annual International Society of Heart Research North American Meeting, Seattle, June 2015.

9. Elena Tsimakouridze, Faisal Alibhai, Cristine Reitz, Tami Martino. Chronotherapy with angiotensin converting enzyme inhibitor at sleep-time benefits outcome post myocardial ischemia-reperfusion (heart attack). Second Conference for the Canadian Society for Chronobiology, Montreal, QC. May 29-31, 2015.

Mini Biography:
In my last undergraduate year at the University of Toronto, I took circadian rhythms courses and conducted a fourth-year reserach project in the field with Dr. M. Ralph. Fascinated by circadian rhythms, I am now pursuing my PhD in translational chronocardiology. As part of my PhD, I am responsible for the murine cardiovascular surgical suite, where I solely perform the myocardial infarction and hemodynamic surgeries. Understanding the role circadian rhythms play and applying the principles to health and disease is a life-long endeavour and my passion.

On the academic level, I am the trainee member on the Board of Directors for the Canadian Society for Chronobiology, responsible for establishing a website, part-taking in decisions to move the society forward, and establish national events for chronobiologists (2013 -present). I am on the committee organizing the first Canadian Chronobiology Simposium, responsible for establishing and organizing the chronobiology mini-school (2012). On the public level, I was on the organizing committee as the attendee communications team lead TED (Technology, Entertainment and Design) X Waterloo (1200 attendees) (2010-2012). In my undergraduate studies, I was on the logistics committee for 2 years organizing Science Rendezvous (2008-2009), and Canadian Wide Science Fair (2009). These events promote innovation, sharing of scientific ideas, and scientific education.

Other Tidbits:
Apart from academics, I enjoy science fiction and fantasy genres (books and TV shows/movies), playing piano and watching TED (Technology, Entertainment and Design) Talks. I like to keep an active lifestyle with hot yoga and biking.