Faisal Alibhai
Supervisor: Dr. Tami A. Martino

Committee:
Dr. Tami A. Martino (advisor)
Dr. Neil MacLusky
Dr. Glen Pyle
Dr. David Wright


Academic Background:
Ph.D. in Biomedical Sciences, Department of Biomedical Sciences, University of Guelph (2012-Present)
Master's of Science, Department of Biomedical Sciences, University of Guelph (2011-Reclassified)
H.BSc in Biomedical Science from the University of Guelph (2007-2011)

Research Interests:
My studies focus on understanding the role circadian rhythms play in the pathophysiology of heart disease and why disruption of these rhythms adversely affects the heart. To answer these questions we combine classical models of cardiovascular disease such as the murine coronary artery ligation model of myocardial infarction, transgenic CLOCK mutant mice, and leading edge molecular biology techniques. My research also aims to understand how the molecular circadian clock mechanism regulates cardiac structure and function in the normal heart over 24hrs. To do this we apply high-throughput "omic" approaches along with bioinformatics analyses to identify novel clock controlled genes and ultimately new insights into circadian regulation of the heart.

Awards:
Canadian Society for Chronobiology Poster Presentation Award (first place) - June 2015
Laforet Research Assistantship - April 2015
Elanco Graduate Scholarship in Cardiology - April 2015
Harry G. Downie Travel Scholarship - April 2015
OVC research symposium Poster Presentation Award - Nov 2014
Ontario Graduate Scholarship - April 2013
Queen Elizabeth II Scholarship - Jan 2013
PhD OVC Fellowship - Sept 2012
PhD Entrance Scholarship - Sept 2012
Ontario Graduate Scholarship - Sept 2011
MSc Entrance Scholarship - Sept 2011

Publications:
8. Basu P, Alibhai FJ, Tsimakouridze EV, Singh RK, Paglialunga S, Holloway GP, Martino TA, Bakovic M. (2015). Male-specific cardiac dysfunction in CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) deficient mice. Mol Cell Biol. 2015 May 18. [Epub ahead of print]. PMID: 25986609

7. Alibhai FJ, Tsimakouridze EV, Reitz CJ, Pyle WG, Martino TA. The Role of the Circadian Clock in Health and Disease. Springer APS. 2015, In Press.

6. Tsimakouridze EV, Alibhai FJ, Martino TA. Therapeutic Implications of Circadian Rhythms for the Cardiovascular System. Front. Pharmacol. 2015 Apr 17. doi: 10.3389/fphar.2015.00077.

5. Bergeron LH, Willcox JM, Alibhai FJ, Connell BJ, Saleh TM, Wilson BC, Summerlee AJS. Relaxin peptide hormones are protective during the early stages of ischemic stroke in male rats. Endocrinology. 2015 Feb;156(2):638-46. PMID: 25456068.

4. Alibhai FJ, Tsimakadourze EV, Reitz CJ, Pyle WG, Martino TA. Circadian Biology and Consequences of Sleep Disturbances for the Cardiovascular System. Can J Cardiol. 2015 Jan 26; [epub ahead of print]

2. Podobed PS, Alibhai FJ, Chow CW, Martino TA. Circadian Regulation of Myocardial Sarcomeric Titin-Cap (Tcap, Telethonin): Identification of Cardiac Clock-Controlled Genes Using Open Access Bioinformatics Data. PLoS One. 2014 Aug 14;9(8):e104907. PMID: 25121604

2. Podobed PS, Pyle WG, Ackloo S, Alibhai FJ, Tsimakouridze EV, Ratcliffe W, Mackay A, Simpson JA, Kirby G, Young ME, Martino TA. The Day/Night Proteome in the Murine Heart. Am J Physiol Regul Integr Comp Physiol. 2014 Jul 15;307(2):R121-37.

1. Alibhai FJ, Tsimakouridze EV, Chinnappareddy N, Wright DC, Billia F, O'Sullivan ML, Pyle WG, Sole MJ, Martino TA. Short term disruption of diurnal rhythms following murine myocardial infarction adversely affects long term myocardial structure and function. Circ Res. May 23, 2014;114(11):1713-22. PMID: 24687134

Abstracts:
1. Lorenzen-Schmidt L, Tsimakouridze EV, Alibhai FJ, Martino TA, Pyle WG. Crossing the Line: A Decrease in the Z-line Protein Cap-Z Worsens Function after Ischemia-Reperfusion Injury. 35th Annual International Society of Heart Research North American Meeting, Seattle, June 2015.

2. Alibhai FJ, Tsimakouridze EV, LaMarre J, O'Sullivan LM, Wright DC, Kroetsch JT, Bolz SS, Burris TP, Martino TA. Circadian Clock Disruption Causes MicroRNA Dysregulation and Leads to Dilated Cardiomyopathy in CLOCK Mutant Mice. Canadian Society for Chronobiology, University of Concordia, May 2015.

3. Kroetsch JT, Alibhai FJ, Martino TA, Bolz SS. TNF Signaling Regulates the Circadian Rhythm of Myogenic Responsiveness and Systemic Blood Pressure. Canadian Society for Chronobiology, University of Concordia, May 2015.

4. Araujo C, Alibhai FJ, Tsimakouridze EV, Martino TA, Pyle WG. Reaching the CapZ: Cardiac CapZ levels are differentially affected in chronic heart failure. Keystone Symposia - Growth and Wasting in Heart and Skeletal Muscle, Sante Fe, New mexico (U.S), Jan 2014.

5. Alibhai FJ, Tsimakouridze EV, Pyle WG, Martino TA. Short term diurnal rhythm disruption post myocardial infarction alters early inflammatory responses and long term worsens outcome. Graduate Research Symposium, University of Guelph, Nov 2013.

6. Alibhai FJ, Tsimakouridze EV, Chinnappareddy N, Billia F, Pyle WG, Sole MJ, Martino TA. Short term Disruption of Diurnal Rhythms Post Myocardial Infarction Worsens Long Term Functional Outcome. Canadian Chronobiology Conference, University of Toronto, May 2013.

7. Podobed P, Pyle WG, Ackloo S, Alibhai FJ, Tsimakouridze E, Young ME, Martino TA. Society for Heart and Vascular Metabolism, Cambridge, Maryland, USA, Sept. 29-Oct.2, 2013.

8. Podobed P, Pyle WG, Young M, Ackloo S, Tsimakouridze EV, Alibhai FJ, Martino TA. Discovery of diurnal cardiac proteome and its role in normal cardiac physiology. Chronobiology Conference, University of Toronto, May 2013.

9. Alibhai FJ, Tsimakouridze E, Chinnappareddy N, Mackay A, Wright DC, Pyle WG, MacLusky N, Martino TA. Circadian Control of Innate Immune Responses and Cardiac Remodeling Post Myocardial Infarction. 3rd annual Muscle Health Awareness Day (MHAD), York University, May, 2012.

Conferences Attended:
Canadian Society for Chronobiology, Montreal, Quebec (2015)
First Conference for the Canadian Society for Chronobiology, Toronto, Ontario (2013)
3rd Annual Muscle Health Awareness Day - York University (2012)

Links:
Science Daily Article: "Simple changes in ICU can help heart attack patients: Study"