Iain R. Lamb
Supervisor: Dr. Coral L. Murrant

Program: PhD Candidate, Human Health and Nutritional Sciences, University of Guelph

Academic Background: MSc, University of Guelph
HBSc, University of Guelph

Awards:
. 2016 Microcirculatory Society Zweifach Student Travel Award
. 2015 Canadian Society for Exercise Physiology Graduate Student Award Winner - Poster Presentation
. 2015 University of Guelph Travel Grant

Research Interests:
Under the mentorship of Dr. Coral L. Murrant, my research revolves around blood flow regulation in skeletal muscle during periods of heightened metabolic demand (i.e. exercise). More specifically, I am interested in how metabolic vasodilators work in conjunction with one another to ensure blood flow and skeletal muscle metabolic demand are sufficiently matched. Currently, I am exploring the idea of vasodilatory redundancy during instances of increased skeletal muscle blood flow. Redundancy describes a paradigm in which one vasodilator can compensate for the loss of another, in the event that its synthesis or release is inhibited. This type of redundant relationship provides a compensatory mechanism ensuring flow and metabolism are always matched. Preliminary data we have collected suggests that during contraction the antagonism of certain vasodilators causes amplification in the vasodilatory effect of others, thereby preserving the concerted relationship between flow and metabolism.

Thesis Topic:
The Role of Redundancy during contraction-induced Increases in Skeletal Muscle Blood Flow.

Publications:
Potassium inhibits nitric oxide and adenosine arteriolar vasodilatation via KIR and Na+/K+-ATPase: implications for redundancy in active hyperaemia. Lamb IR & Murrant CL. J Physiol. 2015; 593(23):5111-26.

Conferences Attended:
. Experimental Biology (EB) 2016 - San Diego, CA - Poster Presentation
. 2016 Smooth Muscle Underground (SMUG) - San Diego, CA
. 2015 North American Vascular Biology Organization (NAVBO) Meeting - Hyannis, MA - Poster Presentation
. Canadian Society for Exercise Physiology (CSEP) 2015 - Hamilton, ON - Poster Presentation
. 6th Annual Muscle Health Awareness Day (2015) - York, ON - Poster Presentation
. 2015 Ontario Exercise Physiology Conference - Barrie, ON - Oral Presentation
. Bodies of Knowledge (BoK) Conference (2015) - Toronto, ON - Oral Presentation
. 2015 Graduate Student Symposium (GSS) - Guelph, ON - Poster Presentation
. Experimental Biology (EB) 2015 - Boston, MA - Poster Presentation
. 2015 Smooth Muscle Underground (SMUG) - Boston, MA
. 2015 Saltin International Course in Exercise Physiology - Toronto, ON - Oral Presentation
. Experimental Biology (EB) 2014 - San Diego, CA - Poster Presentation
. 2014 Smooth Muscle Underground (SMUG) - San Diego, CA
. Experimental Biology (EB) 2013 - Boston, MA - Poster Presentation
. 2013 Smooth Muscle Underground (SMUG) - Boston, MA
. 3rd Annual Muscle Health Awareness Day (2012) - York, ON

Presentations and Abstracts:
1. Iain R. Lamb and Coral L. Murrant. Capillary Response to Skeletal Muscle Contraction: Implications for Redundancy in Microvascular Blood Flow Control FASEB J. April 2016;30:945.1. Presented at Experimental Biology 2016, San Diego, CA. *Travel Award Winner
2. Iain R. Lamb and Coral L. Murrant. Evidence that Redundancy Governs the Active Hyperaemic Response. Presented October 2015 at the North American Vascular Biology Organization Conference, Hyannis, MA. *Selected as Graduate Student Finalist *Travel Award Winner
3. Iain R. Lamb and Coral L. Murrant. Implications of Redundancy during Exercise-induced Increases in Blood Flow. Presented October 2015 at Saltin International Course in Exercise Physiology, Toronto, ON. *Selected to attend.
4. Iain R. Lamb and Coral L. Murrant. The Role of Redundancy in the Integrated Microvascular Response during Exercise-induced increase in Blood Flow. Presented October 2015 at the Canadian Society for Exercise Physiology, Hamilton, ON. *PhD Poster Winner
5. Iain R. Lamb and Coral L. Murrant. Integrated Capillary Responses to Multiple Vasodilators: Implications for Redundancy in Active Hyperaemia. FASEB J. April 2015;29:793.1. Presented at Experimental Biology 2015, Boston, MA
6. Iain R. Lamb and Coral L. Murrant. Integrated Capillary Responses to Multiple Vasodilators: Implications for Redundancy in Active Hyperaemia. Presented May 2015 at Muscle Health Awareness Day, Toronto, ON.
7. Iain R. Lamb and Coral L. Murrant. Integrated Capillary Responses to Multiple Vasodilators: Implications for Redundancy in Active Hyperaemia. Presented April 2015 at Graduate Student Symposium, Guelph, ON.
8. Iain R. Lamb and Coral L. Murrant. Evidence of Redundancy Underlying the Active Hyperaemic Response. Presented May 2015 at Bodies of Knowledge Conference, Toronto, ON.
9. Iain R. Lamb and Coral L. Murrant. Evidence of Redundancy in Exercise-Induced Increases in Blood Flow. Presented February 2015 at Ontario Exercise Physiology Conference, Barrie, ON. *Selected as Graduate Student Finalist
10. Iain R. Lamb and Coral L. Murrant. Vasodilators of active hyperaemia effect one another's action: potassium attenuates the vasodilation produced by nitric oxide and adenosine. FASEB J. April 2014;28:677.15. Presented at Experimental Biology 2014, San Diego, CA
11. Iain R. Lamb and Coral L. Murrant. Vasodilators produced during active hyperaemia interact: potassium attenuates the vasodilatory effect of nitric oxide. FASEB J April 9, 2013;27:901.16. Presented at Experimental Biology 2013, Boston, MA
12. Iain R. Lamb, Thomas J. Jarvis and Coral L. Murrant. Do Student Response Systems Enhance Student Comprehension? Abstract accepted to the 2013 Conference by the Society of Teach and Learning in Higher Education, Kingston, ON

Mini Biography:
Growing up in the bustling metropolis of the one-stoplight town, Sydenham, Ontario I decided to head to the 'big city' and pursue an undergraduate degree in Biomedical Sciences at The University of Guelph. It was during this time I was fortunate enough to meet Dr. Coral L. Murrant and was lucky enough that she took me on as a 4th year research student. It was in her laboratory that I was exposed to the world of skeletal muscle microcirculation. Enamoured with the complexity of the microcirculatory sciences I was lucky enough to convince Dr. Murrant to let me stick around and do an MSc in her lab. During my time there we began to propose a 'poof-in-principal' that a novel redundant regulatory paradigm may be underlying exercise-induced increases in blood flow (Lamb & Murrant 10.1113/JP270613). We hypothesize that this redundant paradigm may act as a compensatory mechanism ensuring the concerted relation between flow and metabolism are maintained, even if a vasodilation is blocked, be it physiologically or pathologically. After my MSc, still enamoured with microcirculation and still in love with Guelph, the next logical step was to sign-up for a PhD. With Dr. Murrant. In Guelph. So that's where I am, currently in my 2nd year of my PhD in the Murrant laboratory and continuing to characterize the redundant response and its role in skeletal muscle blood flow during rest and exercise.

Other Tidbits:
Professional Society Memberships
2012 - The Microcirculatory Society (MCS)
2015 - North American Vascular Biology Organization (NAVBO)
2015 - Canadian Society for Exercise Physiology (CSEP)

Professional Society Offices Held
2015 - The Microcirculatory Society (MCS), Chair of the Trainee Committee