Jordan Klaiman
Supervisor: Dr. Todd Gillis

Academic Background:
2008 – present: Ph.D Candidate, University of Guelph, Department of Integrative Biology
2004– 2008: B.Sc.H, Biology, University of Western Ontario

Awards:
2010 – 2013: Natural Sciences and Engineering Research Council (NSERC)- Canadian Graduate Scholarship
2009-2010: Ontario Graduate Scholarship
2009: Ontario Graduate Scholarship – Science and Technology

Research Interests:
I am interested in the mechanisms that have evolved in the vertebrate cardiac system which enable it to remain functional in cold temperatures. In endothermic species (i.e., mammals and birds), a decrease in body temperature can lead to heart failure. The principle cause of this effect is that the heart has lost its ability to be activated by Ca2+. The situation is very different for some select poikilothermic species, such as the rainbow trout (Oncorhynchus mykiss), that are able to remain active over a wide range of environmental temperatures (~4ºC to ~20ºC) throughout the year. Previous studies have also illustrated that the trout’s heart is functional over this range of temperature. For such physiological plasticity to be possible it is thought that there is significant remodeling of the trout myocardium and of the proteins that compose it.

Thesis Topic:
Characterizing functional changes in the myocardium of the vertebrate heart exposed to cold temperatures.

Conferences Attended:
1) Klaiman, J.M. and Gillis, T.E. Effect of thermal acclimation on isometric force generation of isolated trout cardiac trabeculae. 50th annual meeting of the Canadian Society of Zoologists, May 2011, University of Ottawa, Ottawa, ON
2) Gillis, T.E.* and Klaiman, J.M. The effects of temperature acclimation on the cardiac actin-myosin ATPase and cardiac proteome of Rainbow trout. Society of Experimental Biologists Main Meeting, Prague, July 2010
3) Klaiman, J.M.*, Fenna, A.F., Shiels, H. and Gillis, T.E. The effects of temperature acclimation on the cardiac actin-myosin ATPase and cardiac proteome of Rainbow trout. Oral presentation at the 49th annual meeting of the Canadian Society of Zoologists, May 2010, University of British Columbia, Vancouver, BC
4) Klaiman, J.M.* and Gillis, T.E. The effect of temperature acclimation on the activity and Ca2+ sensitivity of trout cardiac actin-myosin ATPase. Oral presentation at the 48th annual meeting of the Canadian Society of Zoologists, May 2009, U of T Scarborough, Scarborough, ON.
5) Kirkpatrick K.P.*, Roberston A., Klaiman, J.M., Polack, U. and Gillis, T.E. Cloning and characterization of trout cardiac troponin I. Oral presentation at the 48th annual meeting of the Canadian Society of Zoologists, May 2009, U of T Scarborough, Scarborough, ON.
6) Klaiman, J.M.* and Gillis, T.E. The effect of temperature acclimation on the activity and Ca2+ sensitivity of trout cardiac actin-myosin ATPase. Oral presentation at the 18th Annual Comparative Physiology and Biochemistry Workshop, February 2009, Keene, ON.
7) Robertson, A. *, Klaiman, J.M., Kirkpatrick, K., Polack, U. and Gillis, T.E. Cloning and characterization of trout cardiac troponin I. Poster presentation at the18th Annual Comparative Physiology and Biochemistry Workshop, February 2009, Keene, ON

Abstracts/Publications:
Todd E. Gillis and Jordan M. Klaiman. (2011) The influence of PKA treatment on the Ca2+ activation of force generation by trout cardiac muscle. Journal of Experimental Biology 214, 1989-1996
Kelly P. Kirkpatrick, Andrew S. Robertson, Jordan M. Klaiman and Todd E. Gillis. (2011) The Influence of trout cardiac troponin I and PKA phosphorylation on the calcium affinity of the troponin complex. Journal of Experimental Biology 214, 1981-1988
Jordan M. Klaiman, Edwin R. Price and Christopher G. Guglielmo. (2009) Fatty acid composition of pectoralis muscle membrane, intramuscular fat stores and adipose tissue of migrant and wintering white-throated sparrows (Zonotrichia albicollis). Journal of Experimental Biolgoy 212, 3865-3872
Brown, J. C. L., Mcclelland, G. B., Faure, P. A., Klaiman, J. M. & Staples, J. F. (2009) Examining the mechanisms responsible for lower ros release rates in liver mitochondria from the long-lived house sparrow (passer domesticus) and big brown bat (eptesicus fuscus) compared to the short-lived mouse (mus musculus). Mechanisms of Ageing and Development 130, 467-476.