Mathew Platt
Supervisor: Dr. Jeremy A. Simpson

Program: PhD Candidate, Human Health and Nutritional Sciences, University of Guelph

Academic Background:
BSc, University of Guelph

. Ranked 96th of 741 applicants (funding cutoff at the 85th position) in the 2015 CIHR Doctoral Research Award Competition.
. Ontario Graduate Scholarship 2012, 2013, 2014, 2015 and 2016 (awarded yearly)
. Tony and Anne Arrell Scholarship for promising students (2009 & 2011)

Research Interests:
I am drawn to cardiac research by the sheer volume of those afflicted by debilitating cardiac disease. Heart failure is a near certainty if one lives long enough for the years of cardiac stresses (e.g., atherosclerosis, high blood pressure, etc.) to converge into decompensation. It is astounding to me that with all the money, people and time put into understanding heart failure over the last century, it still remains a largely incurable condition with most treatments focusing on the cardiac stresses rather than the direct cardiac remodeling. My interest is in improving our understanding of how the heart remodels to various injuries, and if these patterns of remodeling can be slowed, prevented, or improved to directly treat the cardiac dysfunction without alleviating the cardiac stress.

Thesis Topic:
Investigating cardiac remodeling following acute (myocardial infarction) and chronic (pressure overload/aortic banding) cardiovascular stresses. Specific emphasis is placed on developing novel therapies to treat adverse remodeling.

1. New LA, Martin CE, Scott RP, Platt MJ, Keyvani Chahi A, Stringer CD, Lu P, Samborska B, Eremina V, Simpson JA, Quaggin SE, and Jones N. Nephrin tyrosine phosphorylation is required for maintenance and restoration of podocyte foot process architecture. In press, Journal of the American Society of Nephrology
2. Gillis TE, Klaiman JM, Foster AJ, Platt MJ, Huber JS, Corso MY, and Simpson JA. Dissecting the role of the myofilament in diaphragm dysfunction during the development of heart failure in mice. Am J of Physiol Heart Circ Physiol. 2016;310(5);H572-H586
3. Minsuk K, Platt MJ, Shibasaki T, Quaggin SE, Backx PH, Seino S, Simpson JA and Drucker DJ. GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat Med. 2013;19:567-575.

Manuscripts in Revision:
1. Platt MJ, Huber JS, Brunt KA and Simpson JA. Pulmonary flow as an improved method for determining cardiac output in mice following myocardial infarction. In revision with J Am Soc Echocardiogr, Apr 2015. Revisions resubmitted April 2016.
2. Foster AJ*, Platt MJ*, Arkell AM, Huber JS, Romanova N, Wright DC, Gillis TE, Murrant CL, Brunt KR and Simpson JA. Neurohormonal stimuli increases ventilatory drive triggering diaphragm atrophy in heart failure. In revision with J Clin Inves, Mar 2015 (*authors contributed equally).
3. Yin C, Platt MJ, Wu X, Simpson JA, Toshiyuki A. Hypertrophic Cardiomyopathy in RAF1 Mutant-Associated Noonan Syndrome Requires Complex Cellular Interplay. Submitted to Nat Commun, Oct 2015.

Manuscripts in Preparation for Submission:
1. Platt MJ*, Huber JS*, Romanova N, and Simpson JA. The pathological remodeling of the left and right ventricles in response to left ventricle pressure overload: A temporal biventricular analysis of the transverse aortic constriction model. (*authors contributed equally).
2. Huber JS*, Platt MJ*, Romanova N, and Simpson JA. The pathological remodeling of the left and right ventricles in response to myocardial infarction: A temporal biventricular analysis of the transverse aortic constriction model. (*authors contributed equally).
3. Platt MJ*, Henry S*, Huber JS, Luchmedial S, Brunt KR and Simpson JA. Reduced Infarct Size and Preserved Cardiac Function by a Novel Reactive Pharmacological Intervention. (*authors contributed equally).
4. Romanova N, Platt MJ, Allwood MA and Simpson JA. The differential expression of actin/myostatin and their inhibitors between the left and right ventricles following myocardial infarction.

Mini Biography:
While completing my undergrad in biomedical sciences at the University of Guelph, I was fortunate enough to receive an undergraduate research project scholarship in the summer preceding my 4th and final undergraduate year. I joined Dr. Jeremy Simpson's lab that summer and was immediately enamored by the research process. I quickly determined I was interested in a 4th year research project, and quickly following that enrolled as a masters student again under Dr. Simpson. With a year of grad school under my belt, I determined my goals were too large to be met in a Master program, and instead transferred into the PhD stream. Throughout my PhD, I have been involved in many projects outside of the original scope of my thesis, and in doing so have gained a great deal of appreciation for the time, determination and resources required to successfully complete high impact scientific research. I am presently finishing the 4th year of my PhD with the goal of completing my degree by the end of my 5th year. In the future, I look forward to exploring the business side or scientific research with the ultimate goal of directing the flow of funding into new and exciting projects with significant market promise/viability.

Other Tidbits:
I am a huge sports fan with allegiances first and foremost to any Toronto based team (particularly the Leafs and Jays). I play in two ball hockey leagues year round, and in intramural ice hockey through the winter.