| Dr. Tami Martino |
Research Themes:
Heart Failure, Molecular Biology of Heart Disease, Translational Research, Cardiovascular Physiology, Proteomics of Heart Disease
Academic Background:
B.Sc - McMaster University
MSc, PhD - University of Toronto
Research Institutes worked at: Hospital for Sick Children Toronto; Toronto General Hospital; MARS Discovery
Awards:
Faculty Awards:
Canadian Institute of Health Research Operating Grant (CIHR)
Heart and Stroke Foundation of Ontario, operating Grants
Postdoctoral Awards:
Department of Medicine Mimi and Charles Hollenberg Research Competition Award
Heart and Stroke Foundation of Ontario,
Research Fellowship Award
Canadian Institutes of Health Research (CIHR), Strategic Training Initiative in Cardiovascular Health Research (TACTICS), Research Fellowship Award
Graduate Student Awards:
Canadian Cardiovascular Society, Finalist
Heart and Stroke Foundation of Ontario, Doctoral Fellowship
Canadian Institute of Health Research (CIHR/MRC), Doctoral Fellowship
University of Toronto Open Doctoral Fellowship
Hospital for Sick Children, Research Scholarship
Canadian Society of Microbiology, Research Award
Canadian Foundation for Ileitis and Colitis, Summer Research Award
Research Interests:
- Circadian regulation of cardiac growth and remodeling in cardiovascular diseases such as myocardial infraction (heart attacks), hypertension, cardiac hypertrophy.
- Circadian Dyssynchrony and it's important role in human health - sleep disorders, shift work
- Day/night or circadian variation in physiologic and molecular processes, and it's unique relevance to biomarker discovery and molecular diagnostics.
- State-of-the-art high throughput technologies including microarrays, mass spectrometry proteomics, and bioinformatics.
Facilities/Unique Equipment:
Core proteomics facility (with Dr. Gordon Kirby)
Mass spectrometry (in collaboration)
Circadian rhythms cabinets
Nanodrop
Genomics/microarrays (in collaboration)
Cardiovascular Physiology suite
Funding:
Heart and Stroke Foundation of Ontario (HSFO)
Canadian Institute of Health Research (CIHR)
Canadian Foundation for Innovation (CFI)
Links:
Departmental Faculty Page
Guelph News Article: "Heart Medication Best at Bedtime"
CTV Media Report: The most effective time of day to take medication
The Globe and Mail Article: "Your heart medication is more effective at bedtime"
Guelph News Article: "U of G collaborations look for the causes of cardiovascular disease"
Experimental Biology 2011 Article
Guelph News Article: "Watch Your Circadian Clock to Help Your Ticker"
Students:
Peter Podobed
Elena Tsimakouridze
Nirmala Chinnappareddy
Faisal Alibhai
Heather Chin
Michael Bennardo (Graduated S'10)
Publications:
1. Martino T.A., et al. (2011). The Primary Benefits of Angiotensin Converting Enzyme Inhibition on Cardiac Remodelling Occur During Sleep-Time in Murine Pressure Overload Hypertrophy. Journal of the American College of Cardiology, May17;57(20):2020-2028.
2. - Editorial Focus by Jugdutt BI (2011). Optimizing Pharmacotherapy for Limiting Cardiovascular Remodeling. A Matter of Timing Therapy to Match Biology. Editorial Commentary on Martino T.A. et al., The Primary Benefits of ACE Inhibition, J Am Coll Cardiol, 2011;57:2029-30 (see above).
3. M.J. Sole and Martino, T.A. (2010). Diurnal Molecular Rhythms: Unrecognized Critical Determinants of Cardiovascular Health and Disease. In T.D. Bradley and J.S. Floras (Eds.) Sleep Apnea: Implications in Cardiovascular and Cerebrovascular Disease. Chapter 1. Pages 1-14.
4. Martino T.A., and Sole M.J. (2009). Molecular Time. An Often Overlooked Dimension to Cardiovascular Disease. Circulation Research. Invited Review. Nov 20;105(11):1047-1061.
5.- Editorial Focus by Karyn A. Esser and Martin E. Young (2009) on Highlighted Topic, The Role of Clock Genes in Cardiometabolic Disease. J. Appl. Physiol. 107:1316-1317.
6. Sole M.J., and Martino T.A. (2009). Diurnal Physiology: Core Principles with Application to the Pathogenesis, Diagnosis, Prevention and Treatment of Myocardial Hypertrophy and Failure. Journal of Applied Physiology. Invited Review. 2009, Oct;107(4):1318-27, Epub 2009 Jun 25.
7. Chalmers J.A., Martino T.A., Tata N, Ralph M.R., Sole M.J., Belsham D.D. (2008). Vascular circadian rhythms in a mouse vascular smooth muscle cell line (Movas-1). American Journal of Physiology- Regulatory Integrative and Comparative Physiology, 2008 Nov;295(5):R1529-1538. Epub 2008 Sept 3.
8. Chalmers J.A., Lin SYJ, Martino T.A., Arab S, Liu Peter, Husain M, Sole M.J., Belsham D.D. (2008). Diurnal Profiling of NeuroEndocrine Genes in Murine Heart and Shift in Proopriomelanocortin Gene Expression with Pressure-Overload Cardiac Hypertrophy. Journal of Molecular Endocrinology, 2008 Sept;41(3):117-124. Epub 2008 June 12.
9. Martino T.A, Oudit GY, Herzenberg AM, Tata N, Koletar MM, Kabir GM, Belsham DD, Backx PH, Ralph, MR, and Sole MJ. (2008). Circadian Rhythm Disorganization Produces Profound Cardiovascular and Renal Disease in Hamsters. American Journal of Physiology- Regulatory Integrative and Comparative Physiology, 2008 May;294(5):1675-1683. Epub 2008 Feb 13.
10. - Editorial Focus by Fred W. Turek (2008) on "Circadian Rhythm Disorganization Produces Profound Cardiovascular and Renal Disease in Hamsters: by Martino et al. Am. J. Physiol. Regul. Integr. Comp. Physiol 2008 May;294(5):1672-4. Epub 2008 Mar 19
11. Martino, T.A., Tata N., Bjarnason G.A., Straume M., and Sole M.J. (2007). Diurnal Protein Expression in Blood Revealed by High Throughput Mass Spectrometry Proteomics, and Implications for Translational Medicine and Body-Time-Of-Day (BTOD). American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Sep;293(3):1430-7. Epub Jun 6.
12. Martino, T.A., Tata N, Belsham DD, Straume M, Lee, P, Chalmers J, Pribiag H, Khaper N, Liu PP, Dawood F, Backx PH, Ralph MR, and Sole MJ. (2007). Disturbed Diurnal Rhythm Alters Gene Expression and Exacerbates Cardiovascular Disease with Rescue by Resynchronization. Hypertension, May;49(5):1104-13. Epub Mar 5.
13. Martino T, S. Arab, M. Straume, DD. Belsham, N. Tata, F. Cai, P. Liu, M. Trivieri, M. Ralph, MJ. Sole (2004). Day/night rhythms in gene expression of the normal murine heart. Journal of Molecular Medicine, 86:256-264.
14. Ayach B, Fuse K, Martino T, P. Liu (2003). Dissecting mechanisms of innate and acquired immunity in myocarditis. Current Opinion in Cardiology, 18:175-181.
15. Opavsky, M.A., T. Martino, M. Rabinovitch, C. Richardson, M. Petric, C. Trinidad, J. Penninger, and P. Liu. (2002). The extracellular signal-regulated kinase signaling cascade is a key determinant of susceptibility to coxsackievirus B3 infection and myocarditis in mice. Journal of Clinical Investigation, 109:1561-1569.
16. Martino, T.A., M. Petric, H. Weingartl, J. M. Bergelson, M. A. Opavsky, C. D. Richardson, J. F. Modlin, R. W. Finberg, K. C. Kain, N. Willis, C. J. Gauntt, and P. P. Liu. (2000). The coxsackievirus-adenovirus receptor (CAR) is used by reference strains and clinical isolates representing all six serotypes of coxsackievirus group B and by swine vesicular disease virus. Virology, 271, 99-108.
17. Liu, P., K. Aitken, Y. Y. Kong, M. A. Opavsky, T. Martino, F. Dawood, W. H. Wen, I. Kozieradzki, K. Bachmaier, D. Straus, T. W. Mak, and J.M. Penninger. (2000). The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nature Medicine, 6, 429-434.
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