Dr. Bruce J. Holub
University Professor Emeritus
Office: ANNU 244
Lab: ANNU 362
I pursued graduate work at the University of Toronto with a major in biochemistry and minor in nutrition for the purpose of exploring how altering dietary fat types could alter biochemical pathways via various mechanisms with resulting benefits or detriments to human health.
My dissertation research was focused on the metabolism of essential fatty acids in vivo and their incorporation into membrane phospholipids. My post-doctoral work at the University of Michigan as supported by a MRC Fellowship allowed me to pursue studies on structure/functional relationships of polyunsaturated fatty acids in cellular systems. When I joined the Department of Nutrition (now Department of Human Health and Nutritional Sciences) at the University of Guelph, I focused my research on the potential benefits of omega-3 fatty acids from plant and fish sources with respect to cardiovascular health in humans including research on nutraceuticals/functional foods containing these fatty acids. As well, I have long studied the potential deleterious effects to human health of trans fatty acids found in processed and fast foods.
I have been most privileged to work with numerous dedicated and caring graduate students, research assistants, and collaborating colleagues from Canada and other countries during my research career. I have served as President of the Canadian Society for Nutritional Sciences and Chairman of the Nutrition Task Force for the Heart and Stroke Foundation of Ontario. I am also most appreciative of the awards granted to me including the Borden Award from the Nutrition Society of Canada, The McHenry Award from the Canadian Society for Nutritional Sciences, being elected a Fellow of the International Academy of Cardiovascular Sciences, the Gordin Kaplan award from the Canadian Federation of Biological Societies, and more recently, the 2006 Distinguished Nutrition Leadership Award from the Danone Institute at the Canadian Nutrition Congress in Winnipeg.
I have served on the editorial board of the Canadian Journal of Physiology and Pharmacology as well as Lipids.
B.Sc. - University of Guelph
M.Sc. - University of Toronto
Ph.D. - University of Toronto
Omega-3 fatty acids from fish, fish oils, and plant sources for human health and cardiovascular care. 'Trans' fatty acids and the risk of cardiovascular disease. Nutraceuticals and functional foods. Collaborative research with agri-food units on campus directed towards the development and human evaluation of nutritionally-enhanced and value-added animal products (omega-3 eggs, DHA-milk, etc.) and clinical studies on EPA/DHA concentrates.
Moths, M. D., Dellinger, J. A., Holub , B., Ripley, M.P., McGraw, J. E., Kinnunen, R. E. Omega-3 fatty acids in fish from the Laurentian Lakes Tribal Fisheries. J. Human and Ecological Risk Assessment. 19: in press, 2013.
Ramadeen A., Connelly K.A., Leong-Poi H., Hu X., Fujii H., Van Krieken R., Laurent G., Holub B.J., Bazinet R.P., Dorian P. N-3 polyunsaturated fatty acid supplementation does not reduce vulnerability to atrial fibrillation in remodeling atria. Heart Rhythm. 9: 1115-1122 , 2012.
Rudkowska I., Ponton A., Jacques H., Lavigne C., Holub B.J., Marette A., Vohl M.C. Effects of a supplementation of n-3 polyunsaturated fatty acids with or without fish gelatin on gene expression in peripheral blood mononuclear cells in obese, insulin-resistant subjects. J Nutrigenet Nutrigenomics. 4(4):192-202, 2011.
Holub, BJ., Swidinsky, P., Park, E. Oral Docosapentaenoic Acid (22:5 n-3) is Differentially Incorporated into Phospholipid Pools and Differentially Metabolized to Eicosapentanoic Acid in Tissues from Young Rats. Lipids. 46(5):399-407, 2011.
Rudkowska, I., Ponton, A., Jacques, H., Lavigne, C., Holub, B.J., Marette, A., Vohl, M.C. Effects of a Supplementation of n-3 Polyunsaturated Fatty Acids with or without Fish Gelatin on Gene Expression in Peripheral Blood Mononuclear Cells in Obese, Insulin-Resistant Subjects. Journal Nutrigenet. Nutrigenomics. 26(4):192-202, 2011.
O'Reilly, E., Holub, B.J., Laidlaw, M., Garrioch, C., Wlodek, M.G. Development of a standardized clinical protocol for ranking foods and meals based on postprandial triglyceride responses: The Lipemic Index™. ISRN Vascular Medicine: In press, 2011.
Rudkowska, I., Raymond, C., Ponton, A., Jacques, H., Lavigne, C., Holub, B.J., Maretta, A., Vohl, M.C. Validation of the Use of Peripheral Blood Mononuclear Cells as Surrogate Model for Skeletal Muscle Tissue in Nutrigenomic Studies. OMICS 15(1-2):1-7, 2011.
Ramadeen A, Laurent G, dos Santos C, Hu X, Connelly KA, Holub BJ, Mangat I, Dorian P. n-3 Polyunsaturated Fatty Acids Alter Expression of Fibrotic and Hypertrophic Genes in a Dog Model of Atrial Cardiomyopathy. Heart Rhythm . 7: 520-528 , 2010.
Holub BJ. Docosahexaenoic acid (DHA) and Cardiovascular Disease Risk Factors. Prostaglandins Leukotrienes and Essential Fatty Acids. 81: 199-204, 2009.