Department of Molecular and Cellular Biology Faculty . Dr. Jnanankur Bag

Email: jbag@uoguelph.ca

Office: SSC 3247
Ext: 53390
Lab: SSC 3203
Ext: 54842

Education

B.Sc. - Calcutta
M.Sc. - Calcutta
Ph.D. - Calcutta

Research

Characterization of the molecular machinery involved in mRNA trafficking from the nucleus to the cytoplasm in mammalian cells. The role of poly(A)-binding proteins in mRNA translation.

Selected Publications

Wang Q, Bag J. Ectopic expression of a polyalanine expansion mutant of poly(A)-binding protein N1 in muscle cells in culture inhibits myogenesis. Biochem Biophys Res Commun. 2006 Feb 17;340(3):815-22. Epub 2005 Dec 21.

Patel GP, Ma S, Bag J. The autoregulatory translational control element of poly(A)-binding protein mRNA forms a heteromeric ribonucleoprotein complex. Nucleic Acids Res. 2005 Dec 14;33(22):7074-89. Print 2005.

Ma S, Musa T, Bag J. Reduced stability of mitogen-activated protein kinase kinase-2 mRNA and phosphorylation of poly(A)-binding protein (PABP) in cells overexpressing PABP. J Biol Chem. 2006 Feb 10;281(6):3145-56. Epub 2005 Dec 6.

Wang Q, Mosser DD, Bag J. Induction of HSP70 expression and recruitment of HSC70 and HSP70 in the nucleus reduce aggregation of a polyalanine expansion mutant of PABPN1 in HeLa cells. Hum Mol Genet. 2005 Dec 1;14(23):3673-84. Epub 2005 Oct 20.

Reddy KK, Oitomen FM, Patel GP, Bag J. Perinuclear localization of slow troponin C m RNA in muscle cells is controlled by a cis-element located at its 3' untranslated region.
RNA. 2005 Mar;11(3):294-307.

Lab Members

Ma, Shuhua (Ph.D.)
Patel, Gopal (Ph.D.)
Wang, Qishan (Jason) (Ph.D.)