Kaushik Laboratory

 

                        

                                       

                                               Azad K. Kaushik

                                                                                Immunologist,              

                                                                                University of Guelph,

                                                                                Guelph Ontario N1G 2W1 Canada

                                            

                                                                                Phone: +1 (519) 824 4120 Extension 54389

                                                                                Email:  akaushik@uoguelph.ca  

 

Expertise:

Immunology: Autoimmunity and Systemic Autoimmune Disease,  Clinical Veterinary Immunology and Immunodiagnostics, Molecular Immunogenetics, Protective Immunity, Genomics, Proteomics, Immunoinformatics, Antibody Engineering  and Transgenesis, Vaccinology and Therapy, Idiotypy. (Curriculum vitae)

 

Research Interests:

Antibody Genetics, Antibody Engineering and Transgenesis, Autoimmunity and Systemic Autoimmune Disease,  Clinical Veterinary Immunology


I was intrigued by the mechanisms of immunity, especially generation of diversity (GOD), that protect and at the same time are tolerant to self constituents. The loss of tolerance, however, leads to development of autoimmune disease occasionally. While in France, United States and Switzerland, our research on construction and regulation of immune system in health and disease demonstrated that the same genetic elements of the immune system, some identified by us earlier, defended a host against harmful substances or agents and also led to the origin of pathogenic autoantibodies responsible for systemic autoimmune disease. Our laboratory also demonstrated that B-cell selection early in the development influenced the generation of pathogenic autoantibodies. Such a school of thinking is outlined the book ‘Molecular Immunobiology of Self-Reactivity’ published in 1992 by Marcel Dekker Inc., New York, USA.

   
Studies of the construction of immune system across species led us to focus on the bovine immune system where we identified, classified the genetic elements encoding bovine antibody and defined the mechanisms of antibody diversification. We discovered that limited germline diversity in the cattle genome necessitated the origin  of unique largest sized antibody, yet to be seen in any other species, where an exceptionally long CDR3H is generated resulting in novel configurational diversity. Our current research focuses on structural and functional aspects of antibody engineering for developing next generation of  immunodiagnostics, immunotherapeutics (e.g., construction of single chain Fv (scFv) and novel vaccines [Google Scholar; Web of Science]

 

Research Snapshot:

 


Education:

 

    B.V.Sc. (Honours)                  Haryana Ag. University, Veterinary Medicine, 1976

    M.V.Sc.                                    Haryana Ag. University, Immunology, 1978

    D.Sc.  (Tres Honorable)       Pasteur Institute (Universite Paris VII), 1987

Honors:

  1. • Indo-French Research Scholar (1983-86)

  2. • Medical Scholar, French Medical Research Foundation, Paris, France (1986-87)

  3. • Lupus Fellow, The SLE Foundation, New York, USA (1988)

  4. The Esther Z. Greenberg Honors Chair in Biomedical Research and Visiting Professor, Oklahoma Medical Research Foundation, USA (1998)

  5. • Consultant, US Veterinary Immune Reagent Network, 2006-present (www.umass.edu/vetimm/ruminants/index.html).

  6. • Faculty, International Union of Immunological Societies (2002-08)

  7. • IMGT Expert (Bovine Immunoglobulin; http://imgt.cines.fr/textes/IMGTindex/IMGTexperts.html)

  8. • Member, American Association of Immunolgists Veterinary immunology Committee  

  9.