Myotonic
dog. "Kai", a 4-year-old female spayed Australian
Cattle Dog with a life-long history of muscle stiffness and
hypertrophy, is homozygous for a mutation of CLCN1.
In this video she is seen chasing a soccer ball following
a short rest. After a few strides she experiences severe skeletal
muscle rigidity that causes her to fall. She recovers within
seconds.
(Images and name used with permission
of the owner)
Myotonic
dog. Another episode of transient muscle rigidity in Kai.
Myotonic
dog. Kai after warming up. She is able to run (stiffly)
without falling.
This research
is part of an on-going collaboration between Drs Brad Hanna
(Biomedical Sciences), Andrew Bendall (Molecular & Cellular
Biology), and Roberto Poma (Clinical Studies) at the University
of Guelph. For further information please contact Dr.
Brad Hanna.