Bruce J. Holub
Prof. Bruce J. Holub

University Professor Emeritus
Dept. of Human Health & Nutritional Sciences
University of Guelph
Phone: 519-824-4120 ext. 53743
Fax: 519-763-5902
Email: bholub@uoguelph.ca
Homepage: http://www.uoguelph.ca/~bholub
Mailing address: 
Animal Science and Nutrition Bldg., Room 244 (Lab 362)
Dept. of Human Health& Nutritional Sciences
University of Guelph, Guelph, ON

                         Canada, N1G 2W1
 

B.Sc. - University of Guelph, Canada (1967)
M.Sc. - University of Toronto, Canada (1969)
Ph.D. - University of Toronto, Canada (1971)
(Major - Biochemistry; Minor - Nutrition)
Postdoc. - University of Michigan, USA
Joined the University of Guelph Faculty in 1973

Research Interests 

Dietary Lipids/Fatty Acids (Omega-3, others), Nutraceuticals, Functional Foods and the Management of Cardiovascular Disease (CVD) and Associated Risk Factors


Dietary Lipids/Fatty Acids (Omega-3, others), Nutraceuticals, Functional Foods and the Management of Cardiovascular Disease (CVD) and associated Risk Factors 

    Our research is focused upon human-based research trials wherein various dietary fatty acid components (omega-3 fatty acids from fish/fish oils, etc.) plus selected nutraceuticals/functional foods are evaluated with respect to their potential to favourably influence a whole range of risk factors for CVD. The risk factors of interest are those which are currently measured in the public health-care system (e.g. LDL-cholesterol, HDL-cholesterol, triglyceride, etc.) as well as those with are not available currently in the health care system. The latter include various thrombogenic, atherogenic, inflammatory, and other risk factors. The potential impact of modifying dietary constituents ranging from lipid/fatty acids through to nutraceuticals and functional foods on these conventional and non-conventional risk factors are under current investigation.
    Our research group has also developed particular interest in sectors within the population including males and females of varying ages, ethnic backgrounds, stages of life (e.g. post-menopausal women on or not on hormone-replacement therapy, etc.) since there is evidence now that genetic and other factors can influence the responsiveness of individuals to given nutritional interventions. In addition, we are also extensively involved in collaborative epidemiological work with groups within North America (including medical centres and health agencies in Canada and the US) as well as international groups (in Greenland, elsewhere). The listed recent publications represents a sampling of published studies from our laboratory which encompass some of the aforementioned research activities. 

Recent selected publications:

Holub, BJ., Swidinsky, P., Park, E. Oral Docosapentaenoic Acid (22:5 n-3) is Differentially Incorporated into Phospholipid Pools and Differentially Metabolized to Eicosapentanoic Acid in Tissues from Young Rats. Lipids. 2011. 46: 399-407. Paper

Rudkowska, I., Raymond, C., Ponton, A., Jacques, H., Lavigne, C., Holub, B.J., Maretta, A., Vohl, M.C. Validation of the Use of Peripheral Blood Mononuclear Cells as Surrogate Model for Skeletal Muscle Tissue in Nutrigenomic Studies. 2011. 15: (1-2): 1-7.

West, SG, Krick AL, Klein LC, Zhao G, Wojtowicz TF, McGuiness M, Bagshaw DM, Wagner P, Ceballos RM, Holub BJ, Kris-Etherton PM. Effects of Diets High in Walnuts and Flax Oil on Hemodynamic Responses to Stress and Vascular Endothelial Function. Journal Am. Coll. Nutr. 2010. 29(6):595-603, 2010. Paper

Ramadeen, A., Laurent, G., DosSantos, C., Hu, X., Connelly, K., Holub, B., Mangat, I. and Dorian, P. N-3 Polyunsaturated Fatty Acids Alter Gene Expression Profile and Reduce Vulnerability to Atrial Fibrillation in a Dog Model of Cardiomyopathy. Heart Rhythm. 2010. 7 (4): 520-528. Paper

Holub, B., Piekarski, J., Rowe, W. and Wlodek, M. Correlation of omega-3 levels in serum phospholipid from 2053 human blood samples with key fatty acid ratios. Nutrition Journal. 2009. 8: 58-65. Paper

Holub, B.J. Docosahexaenoic acid (DHA) and cardiovascular risk factors. Prostaglandins Leukot Essent Fatty Acids. 2009. 81(2-3):199-204. Paper

Lucas, M., Dewailly, E., Blanchet, C., Gingras, S., Holub, B.J. Plasma omega-3 and psychological distress among Nunavik Inuit ( Canada). Psychiatry Res. 2009. 167(3):266-78. Paper

Hanwell, H.E.C., Kay, C.D., Lampe, J.W., Holub, B.J., Duncan, A.M. Acute fish oil and soy isoflavone supplementation increase postprandial serum (n-3) polyunsaturated fatty acids and isoflavones but do not affect triacylglycerol or biomarkers of oxidative stress in overweight and obese hypertriglyceridemic men. J. Nutr.139(6):1128-1134, 2009. Paper.

Lucas, M., Dewailly, E., Blanchet, C., Gingras, S., Holub, B.J. Plasma n-3 fatty acids and psychological distress in aboriginal Cree Indians ( Canada). Public Health Nutr. Feb 26:1-9. 2009. Paper.

Madden, S.M.M., Garrioch, C.F., and Holub, B.J. Direct diet quantification indicates low intakes of (n-3) fatty acids in children 4 to 8 years old. J. Nutr. 139:528-532. 2009.Paper.

Barrow, C.J., Nolan C., and Holub B.J. Bioequivalence of encapsulated and microencapsulated fish-oil supplementation. Journal of Functional Foods. 1:38-43, 2009.Paper.

Ouellet, V., Weisnagel, S.J., Marois, J., Bergeron, J., Julien, P., Gougeon, R., Tchernof, A., Holub, B.J., and Jacques, H. Dietary cod protein reduces plasma C-reactive protein in insulin-resistant men and women. J Nutr.138(12): 2386-2391, 2008.Paper.

Griel, AE., Cao, Y., Bagshaw, DD., Cifelli, AM., Holub, B., Kris-Etherton, PM. A macadamia nut-rich diet reduces total and LDL-cholesterol in mildly hypercholesterolemic men and women. J Nutr. 138(4):761-767, 2008.Paper.

Laurent, G., Moe, G., Hu, X., Holub, B., Leong-Poi, H., Trogadis, J., Connelly, K., Courtman, D., Strauss, BH., Dorian, P. Long chain n-3 polyunsaturated fatty acids reduce atrial vulnerability in a novel canine pacing model. Cardiovasc Res. 77(1):89-97, 2008.Paper.

Holub, B. J. Treating hypertriglyceridemia. CMAJ. 177(6): 603-606, 2007. Paper

Hogg RJ, Lee J, Nardelli N, Julian BA, Cattran D, Waldo B, Wyatt R, Jennette C, Sibley R, Hyland K, Fitzgibbons L, Hirschmann G, Donadio JV, Holub BJ: Clinical trial to evaluate omega-3 fatty acids and alternate day prednisone in patients with IgA nephropathy: Report from the Southwest Pediatric Nephrology Study Group. Clin J Am Soc Nephrol 1:467–474, 2006.  Paper

Rose, E., and B. Holub. Effects of a liquid egg product containing fish oil on selected cardiovascular disease risk factors: a randomized crossover trial. Food Research International. 39:910-916, 2006. Paper


Relevant Links 


U of G Home
Bruce J. Holub, Ph.D.,
 University Professor Emeritus


Department of Human Health & Nutritional Sciences
University of Guelph
Guelph, Ontario, Canada N1G 2W1
bholub@uoguelph.ca
 

Revised: July 2011

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