ABOUT DR. FRANCES J. SHAROM
| Education | Conference organization |
Education
| 1971-1975 | University of Guelph, B.Sc. Honours (with Distinction) in Chemistry |
|---|---|
| 1975-1978 | University of Western Ontario, Ph.D. in Biochemistry (advisor: C.W.M. Grant) |
Postdoctoral training
| 1979-1980 | Postdoctoral Fellow, Department of Chemistry, and Biochemistry University of Guelph (advisor: A. Mellors) |
|---|
Academic appointments
| 1980-1984 | NSERC University Research Fellow and Assistant Professor, Department of Chemistry and Biochemistry, University of Guelph |
|---|---|
| 1984-1987 | Assistant Professor (tenure-track), Department of Chemistry and Biochemistry, University of Guelph. Granted tenure December 1986 |
| 1987-1994 | Associate Professor, Department of Chemistry and Biochemistry, University of Guelph |
| 1991-1994 | Director, Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry (GWC)2 |
| 1994-2004 | Professor, Department of Chemistry and Biochemistry, University of Guelph |
| 2003-2008 | Director, Biophysics Interdepartmental Group (BIG) graduate program |
| 2003-present | Canada Research Chair in Membrane Protein Biology |
| 2004-present | Professor, Department of Molecular and Cellular Biology, University of Guelph |
Research and teaching awards
| 1975-1978 | Ph.D. Studentship, Medical Research Council of Canada |
|---|---|
| 1980-1984 | University Research Fellow, Natural Sciences and Engineering Research Council of Canada |
| 1992 | Special Merit Professorial Teaching Award |
| 1992 | Ontario Confederation of Faculty Associations (OCUFA) Teaching Award |
| 1993 | Lieutenant Governor’s Award for Teaching Excellence |
| 2002 | College of Physical and Engineering Science Distinguished Professor Award |
| 2003-present | Canada Research Chair in Membrane Protein Biology (Tier 1) |
Society memberships and executive positions
| Member, Canadian Society of Biochemistry, Molecular and Cellular Biology (CSBMCB | |
| Member, American Association for Cancer Research (AACR) | |
| Member, American Society for Biochemistry and Molecular Biology (ASBMB) | |
| Member, Biophysical Society | |
| 1996-1999 | Councillor, CSBMCB |
| 1990-2000 | Vice-President, CSBMCB |
| 2000-2001 | President, CSBMCB |
| 2001-2002 | Past-President, CSBMCB |
| 2002-2008 | Editor, CSBMCB Bulletin |
| 2003-present | Councillor, CSBMCB |
| 2010-present | Member, Publications Committee of the ASBMB |
Professional positions
| 2008-present | Editor, Biochemical Journal (Portland Press, London U.K.) |
|---|
Conference organization
| 1998-2003 | Member, Scientific Program Committee for the 1993 International Congress of the IUBMB |
|---|---|
| 2000-2001 | Member, Local Organizing Committee for the 44th Annual Meeting of the CSBMCB, held in Alliston, ON |
| 2001-2002 | Member, Organizing Committee for the 45th Annual Meeting of the CSBMCB, held in Banff, AB |
| 2005-2006 | Member, Organizing Committee for the 49th Annual Meeting of the CSBMCB, held in Niagara-on-the-Lake, ON |
| 2006-2007 | Member, Organizing Committee for the 50th Annual Meeting of the CSBMCB, held in Montreal, QC |
Grant panels
| 1997-1999 | Member, Grants Panel G, National Cancer Institute of Canada |
|---|---|
| 1999 | Member, Group Grant Site Review Team, Medical Research Council of Canada |
| 1999-2000 | ORDCF Medical Review Panel |
| 2000-2002 | Member, Biochemistry and Molecular Biology-A Grants Panel, Medical Research Council of Canada (MRC)/Canadian Institutes of Health Research (CIHR). |
| 2004 | Member, Biochemistry and Molecular Biology-A Grants Panel, Canadian Institutes of Health Research (CIHR). |
| 2004 | Invited member of NCASRD (National Consultation on Access to Scientific Research Data) Forum, held at Library and Archives Canada, Ottawa, ON |
| 2005 | External member, NIH Study Section on Biophysics of Synapses, Channels and Transporters |
| 2006 | External reviewer, University of Ottawa undergraduate program in Biochemistry |
| 2006 | External reviewer for CIHR Metabolism Grant Review Panel |
Consulting activities
| 1994 | Genzyme, Framingham, MA |
|---|---|
| 2002-2004 | Active Pass Pharmaceuticals, Vancouver, BC |
| 2003-2006 | AstraZeneca, Wilmington, DE |
| 2008-present | GLSynthesis, Worcester, MA |
Invited symposium presentations (since 2001)
| 1998 | 8th Fisher Winternational Symposium on Cellular and Molecular Biology, Banff
“The molecular basis of multidrug resistance; exploring the structure and function of the P-glycoprotein efflux pump” |
|---|---|
| 1998 | 15th BCCE, University of Waterloo
“The cell membrane and cancer: friend or foe?” |
| 1999 | Second FEBS Advanced Lecture Course: ATP Binding Cassette Transporters; from Multidrug Resistance to Genetic Disease, Gosau, Austria
“Fluorescence spectroscopic approaches to understanding the structure and function of the P-glycoprotein multidrug transporter” |
| 1999 | FASEB Conference on Transport ATPases, Snowmass, CO
“Fluorescence approaches for studying the structure and substrate interactions of the P-glycoprotein multidrug transporter” |
| 1999 | Joint meeting of the Pharmacological Society of Canada and the Swiss Society of Pharmacology and Toxicology, Zermatt, Switzerland
“New perspectives on the structure and function of the multidrug resistance transporters” |
| 2001 | Third FEBS Advanced Lecture Course: ATP Binding Cassette Transporters; from Multidrug Resistance to Genetic Disease (ABC2001), Gosau, Austria
“Interaction of the multidrug transporter with nucleotides, drugs and phospholipids: towards an understanding of the structure and catalytic cycle of P-glycoprotein” |
| 2002 | First JBS Biofrontier Symposium: Membrane Transporters; Structure and Function Relationship - Insights into ABC Transporters, Yufuin, Japan
“Interaction of P-glycoprotein with nucleotides, drugs and phospholipids” |
| 2002 | American Association of Pharmaceutical Scientists Annual Meeting, Toronto, ON
“Fluorescence spectroscopic approaches for studying the structure and function of the P-glycoprotein multidrug transporter” |
| 2002 | International Conference on Niemann-Pick Type C Disease, Tucson, AZ
“Transport and lipid flippase functions of P-glycoprotein, a promiscuous ABC transporter” |
| 2003 | Gordon Conference on Multidrug Efflux Systems, Ventura, CA
“Structure and substrate interactions of P-glycoprotein” |
| 2004 | Ara Parseghian Medical Research Foundation Scientific Meeting, Tucson, AZ
“Characterization of the lipid flippase, transport and cholesterol efflux functions of the NPC1 protein” |
| 2004 | ATP-Binding Cassette (ABC) Proteins; Towards a Structural View of Mechanism, Satellite Meeting of the 48th Annual Biophysical Society Meeting, Baltimore, MD
“Progress towards understanding the catalytic cycle of the P-glycoprotein efflux pump” |
| 2005 | Ara Parseghian Medical Research Foundation Scientific Meeting, Tucson, AZ
“Characterization of the lipid flippase, transport and cholesterol efflux functions of the NPC1 protein” |
| 2005 | FASEB Summer Conference on Transport ATPases: Genomics, Mechanisms and Relevance to Disease, Saxton's River, VT
“Fluorescence studies of P-glycoprotein substrate binding and catalytic cycle” |
| 2005 | Gordon Conference on Multi-Drug Efflux Systems, Magdalen College, Oxford, U.K. Discussion Leader and Session Chair: Mechanism of energy supply and coupling to drug efflux |
| 2006 | FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins: from Multidrug Resistance to Genetic Diseases, Innsbruck, Austria
Workshop Chair: Tools and Methods for Research on ABC Proteins; Speaker: “Fluorescence spectroscopy as a tool for studying ABC protein structure and function” |
| 2006 | 49th CSBMCB Annual Meeting on Membrane Proteins in Health and Disease, Niagara-on-the-Lake, ON
Jeanne Manery Fisher Award Lecture: “Fluorescence studies of the P-glycoprotein multidrug transporter” |
| 2006 | Ara Parseghian Medical Research Foundation Scientific Meeting, Tucson, AZ
“Purification and reconstitution of human NPC1, and characterization of its substrate binding properties using intrinsic tryptophan fluorescence” |
| 2006 | Gordon Conference on Molecular and Cellular Bioenergetics, Proctor Academy, NH Discussion Leader and Session Chair: Structures and coupling mechanisms in membrane transport systems |
| 2007 | Ara Parseghian Medical Research Foundation Scientific Meeting Tucson, AZ
“Purification of human NPC1 and characterization of its binding to sterols and lipids” |
| 2007 | AAPS Workshop on Drug Transporters in ADME: From the Bench to the Bedside, North Bethesda, MD
“Function and catalytic cycle of ABC drug transporters” |
| 2008 | Ara Parseghian Medical Research Foundation Scientific Meeting, Tucson, AZ
“Purification of human NPC1 and characterization of its binding to fluorescent sterols” |
| 2008 | ASBMB Conference on Cellular lipid transport: connecting fundamental membrane assembly processes to human disease, Canmore, AB
“The reconstituted MsbA protein is a phospholipid flippase” |
| 2009 | CSPS Annual Symposium, Toronto, ON
“Clinical significance of multidrug efflux transporters” |
| 2010 | ASBMB Annual Meeting, Anaheim, CA
“Lipid transporters and binding proteins; MsbA and NPC1” |
| 2010 | FASEB Summer Conference on Transport ATPases: from Molecules to Maladies, Snowmass, CO
“Probing the drug binding pocket and catalytic cycle of P-glycoprotein” |
| 2011 | Gordon Conference on Multi-Drug Efflux Systems, Les Diablerets, Switzerland
“Probing the drug-binding pocket and drug transport mechanism of P-glycoprotein (ABCB1)”, invitation accepted |
Undergraduate courses taught
| BIOC*4580 | Membrane Biochemistry |
|---|---|
| BIOC*3570 | Analytical Biochemistry |
| BIOC*3560 | Structure and Function in Biochemistry |
| CHEM*4900 | Research Project in Chemistry & Biochemistry I |
| CHEM*4910 | Research Project in Chemistry & Biochemistry II |
| MCB*4500 | Research Project in Molecular & Cellular Biology I |
| MCB*4501 | Research Project in Molecular & Cellular Biology II |
Graduate courses taught
| CHEM*7380 | Cell Membranes and Cell Surfaces |
|---|---|
| BIOP*6000 | Concepts in Biophysics |
| CHEM*7330 | Glycolipids and Glycoproteins |