Fall semester 01:
Elements of Calculus Tu-Th 8:30-10:00, Th 2:30-3:20
Environmental Transport Modeling MWF 12:30-1:20
Winter Semester 02
Elements of Calculus II MWF 8:30-9:30 AXEL 200
Office hours: I am normally in the office every day.
Drop by or give a call or e-mail (except MATH1080 students, who should first access the
Math Learning Center for help or should see me personally.)
Research Group Summer 2001
Above, Left to right: Rod Gentry, Nichol Watt, Sharene Bungay, Michael
Links to Courses
that I have recently taught.
Degrees: B.A., M.A. Western Washington State, Ph.D. University of
Visiting appointments at other institutions:
- Risk Assessment Section, Health and Safety Research Div. Oak Ridge National Lab. 1978-79
- Dept. of Physiology and Pharmacology, Beijing Vet. College 1985
- Institute for Social and Preventive Medicine, University of Bern, Switzerland 1986
- Mathematics Dept. Univ. of Calif. Davis. 1988-89
- Dept. of Animal Sciences, Univ. of Illinois, Urbana- Champaign, 1995
- Institute for Theoretical Dynamics, Univ. of Calif. Davis 1996
- The kinetics of blood coagulation, specifically Tissue Factor
activation of factor X.
- The kinetics of flow reactors .
- Surface mediated enzymatic reactions.
- Biochemical kinetics and physiological processes.
My principal research is part of a collaborative project that is focused on elucidating
the mechanisms and kinetics of the Tissue Factor pathway leading to blood coagulation.
This modeling entails close collaboration with medical researchers, and involves the
development and analysis of both differential equation models and stochastic computer
simulation models of the underlying physic-chemical processes. Our current work is
focusing on two problems. One is to establish the kinetic role of rotational diffusion of
membrane bound substrates that diffuse transitionally to an enzyme on the membrane. The
other is to understand the kinetics of a flow reactor, this is an experimental analog of a
blood vessel, consisting of a cylinder with enzymes attached to its surface through which
a fluid carrying the substrate flows. In such systems, both connective and diffusional
processes are involved in carrying the substrate to the enzyme attached on the tube wall.
The mathematical analysis of this problem is difficult because of the boundary conditions.
To explore the kinetics of such reactors for different enzyme density on the tube surface
and for different substrate concentrations entering the system we are utilizing a
simulation model that incorporates fluid flow, diffusion, and enzymatic kinetics.
Research associates include:
- Jolon Jesty , Dept.
of Medicine,and Ed Beltrami, Dept. of Mathematics, State University of New York,
Konigsberg, Dept. of Molecular Biophysics and Biochemistry, Yale University.
- Li Qiang Ye, Guangzhou International School, Longdong, Tianhe Distric,
Guangzhou, Guangdong, China 51052.
Recent Publications and Presentations.
- Andree, HM, Contino, PB, Repke, D, Gentry, R, and Nemerson, Y. "Transport Rate
Limited Catalysis on Macroscopic Surfaces: The Activation of Factor X in a Continuous Flow
Enzyme Reactor." Biochemistry, 33:4368- 4374, 1994.
- Rodney Gentry, Liqiang Ye, and Yale Nemerson. "A Microscopic Model of Enzyme
Kinetics." The Biophysical Journal, 69:356-361, 1995.
- Rodney Gentry, Liqiang Ye, and Yale Nemerson. "Surface Mediated Enzymatic
Reactions: Simulations of Tissue Factor Activation of Factor X on a Lipid Surface." The
Biophysical Journal, 69:362-371, 1995.
- Rodney D. Gentry and Liqiang Ye, "Modeling surface mediated enzymatic reactions in
a flow system." In Computer Simulations in Biomedicine, C. A.
Brebbia, T. T. Hart, and H. Power editors. CML Publications, 225-323, 1995.
- C.U. Leon-Velarde, I. McMillan, R.D. Gentry, and J.W. Wilton, "Models for
Estimating Typical Lactation Curves in Dairy Cattle.", Journal of Animal Breeding
and Genetics, 112:333-340, 1995.
- L. Ye, R. D. Gentry and Y. Nemerson. "Simulation of lipid surface reactions in
blood coagulation." Fed. Am. Soc. Exp. Biol. Fed. Proceedings, 2,
- L. Ye, R. D. Gentry and Y. Nemerson. "A random walk model of lipid surface
reactions in blood coagulation." Can. Fed. Biol. Soc. Proceedings, 31,
Abs. 545 1988.
- R. Gentry and Y. Nemerson. "The activation of prothrombin: a linked reactive
kinetic model." Proc. XIth Int. Congress on Thrombosis and Haemostasis,
Belgium, July 6-10, 1987.
- Y. Nemerson and R. D. Gentry. " An ordered addition essential activation model of
the Tissue Factor pathway of coagulation: Evidence for a conformational cage." Biochemistry,
- R. Bach, R. Gentry and Y. Nemerson. "Factor VII binding to Tissue Factor in
reconstituted phospholipid vesicles: Induction of cooperativity by
phosphatidylserine." Biochemistry, 25:401-419, 1986.
- R. D. Gentry. Introduction to applied Calculus for the Life Sciences,
Addison-Wesley, Reading, Mass., 1978.
- Rodney D. Gentry, APPLIED CALCULUS, Harper Collins, 1995, p725
- BSc MSc Memorial University NFL
- PhD Thesis topic: Modeling the Thrombolytic System in Follicular Fluid
- Personal Web Page: http://www.math.mun.ca/~sharene/
- E-mail: email@example.com
- Lisa Barrucco Stansfield
- MSc Project: "Influence of Rotational Diffusion on Surface Reactions in
Coagulation: Simulation Studies" (1997)
- Currently: Programmer Analyst with The Royal Bank, Toronto
E-Mail to firstname.lastname@example.org
- Andy Johnston
- Optimizing Insulin Delivery in an Artificial Beta-cell Environment., MSc
- Currently: employed with Northern Digital, Waterloo Ontario
E-Mail to email@example.com
- Jill Degroote
- Mathematical Modeling of HIV Transmission., MSc 1994
- Currently: Enjoying Life.
- Was a PhD student Dept. Biostatistics, Community Health Sciences, University of
Calgary but has moved to Pensylvania and is raising two children.
- Dana Rusu
- Nonlinear kinetics models of reactions catalyzed by enzymes attached to the
interior surface of a tubular flow reactor. MSc 1994
- Currently: Teacher training
- Cindy-Ann Ritchie
- Two Approaches to modelling daily temperature data using time series analysis.,
Currently: employed with GLAXO, Toronto Ontario.
- Liqiang Ye
- MSc 1986 A study of an automated manufacturing process: modeling and simulation
of an automotive assembly line.
- PhD. Thesis: Computer simulation studies of lipid surface reactions in blood
coagulation., PhD 1990 (Biophysics)
- Post-Doctoral Fellow. 1991-4
- Currently: Principal, Guangzhou International School, Longdong, Tianhe Distric,
Guangzhou, Guangdong, China 51052. firstname.lastname@example.org
|Nicole Watt Summer 2001
Liqiang Ye 1992-4
Andrew Kuharsky 1998-9
Last updated 03/13/2002