Nanopect-RNA adducts for RNA-therapeutic and RNA vaccine delivery for animal and human health protection and disease prevention

Lead Applicant: Gopinadhan Paliyath

Research Priority: Animal Health & Welfare Projects

Program Type: Gryphon's LAAIR

Funding Cycle: 2021/2022

Research Centre: NA

Research Summary: RNA interference (RNAi) is a potent and specific new therapeutic modality for animals and humans. However, these molecules require a delivery system that shields them from the immune system. The Paliyath lab has isolated a novel nanoproduct from sour cherry fruit that enables oral delivery of these biological molecules. We propose to demonstrate that RNA-Nanopect adducts can safely and efficiently be delivered into mammalian cells.