{"id":2326,"date":"2018-05-14T00:00:00","date_gmt":"2018-05-14T04:00:00","guid":{"rendered":"https:\/\/www.porticomagazine.ca\/2018\/05\/u-of-g-study-uncovers-new-insights-into-cause-of-cell-death-in-parkinsons\/"},"modified":"2020-10-28T14:40:19","modified_gmt":"2020-10-28T18:40:19","slug":"u-of-g-study-uncovers-new-insights-into-cause-of-cell-death-in-parkinsons","status":"publish","type":"post","link":"https:\/\/porticomagazine.ca\/2018\/05\/u-of-g-study-uncovers-new-insights-into-cause-of-cell-death-in-parkinsons\/","title":{"rendered":"U of G Study Uncovers New Insights Into Cause of Cell Death in Parkinson\u2019s"},"content":{"rendered":"<p>A U of G researcher has discovered one of the factors behind nerve cell death in Parkinson\u2019s disease, unlocking the potential for treatment to slow the progression of this fatal neurodegenerative disorder.<\/p>\n<p>Prof. Scott Ryan has found that cardiolipin, a molecule inside nerve cells, helps ensure that a protein called alpha-synuclein folds properly. Misfolding of this protein leads to protein deposits that are the hallmark of Parkinson\u2019s disease.<\/p>\n<p>These deposits are toxic to nerve cells that control voluntary movement. When too many of these deposits accumulate, nerve cells die.<\/p>\n<p>\u201cIdentifying the crucial role cardiolipin plays in keeping these proteins functional means cardiolipin may represent a new target for development of therapies against Parkinson\u2019s disease,\u201d says Ryan, a professor in U of G\u2019s <a href=\"https:\/\/www.uoguelph.ca\/mcb\/\">Department of Molecular and Cellular Biology<\/a>.<\/p>\n<p>\u201cCurrently there are no treatments that stop nerve cells from dying.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A U of G researcher has discovered one of the factors behind nerve cell death in Parkinson\u2019s disease, unlocking the potential for treatment to slow the progression of this fatal neurodegenerative disorder. Prof. Scott Ryan has found that cardiolipin, a molecule inside nerve cells, helps ensure that a protein called alpha-synuclein folds properly. Misfolding of<\/p>\n","protected":false},"author":7,"featured_media":2365,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":""},"categories":[14],"tags":[311,308,310,309,306,307],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v17.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>U of G Study Uncovers New Insights Into Cause of Cell Death in Parkinson\u2019s -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/porticomagazine.ca\/2018\/05\/u-of-g-study-uncovers-new-insights-into-cause-of-cell-death-in-parkinsons\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"U of G Study Uncovers New Insights Into Cause of Cell Death in Parkinson\u2019s -\" \/>\n<meta property=\"og:description\" content=\"A U of G researcher has discovered one of the factors behind nerve cell death in Parkinson\u2019s disease, unlocking the potential for treatment to slow the progression of this fatal neurodegenerative disorder. Prof. Scott Ryan has found that cardiolipin, a molecule inside nerve cells, helps ensure that a protein called alpha-synuclein folds properly. 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