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Published by Communications and Public Affairs (519) 824-4120, Ext. 56982 or 53338

News Release

February 03, 2005

U of G prof uncovers roots of social recognition

A University of Guelph psychology professor has made a groundbreaking discovery that explains how genes work together to form the basis of social recognition.

Elena Choleris studied the genetic interactions necessary for one mouse to recognize another. Her research, which could have implications for better understanding human disorders affecting sociality, is featured in the January issue of Science Magazine and was published in the Proceedings of the National Academy of Sciences of the United States of America and the Journal of Neuroendocrinology.

“If the individuals of one species can’t recognize others, it means that can’t be a social species, so recognition is really the basis of all social life,” she said.

Although scientists have known that estrogens – through their alpha receptor and the gene for neuropeptide oxytocin – are involved in the regulation of social recognition in mice, Choleris’s studies were the first to show that the most recently discovered estrogen receptor, beta, and the gene for oxytocin’s receptor are also needed for social recognition.

Based on her most recent discoveries, Choleris has concluded that, in the regulation of social recognition, these four genes are connected together in what she calls a “micronet.” “Like a net, if you cut it at any one of these four points, then you will block social recognition because all the genes have to work together as a mechanism for social recognition to happen,” said Choleris, who’s the lead author of the study that she completed with Don Pfaff of Rockefeller University. “I see this as the core control of social recognition.”

For the study, Choleris put a new mouse in a mouse’s cage for five minutes. After a 15-minute break, she put the new mouse back in the cage and repeated this process with the same mice four times. “By the fourth time, a mouse with normal genes will have figured out that the visitor mouse is always the same, so the social investigation – the interest shown towards the visitor – declines,” she said. The fifth time, Choleris introduced a different mouse, and the resident mouse immediately recognized it was a new visitor and started the exam process all over again.

When Choleris did the same experiment with a resident mouse missing one of the four genes that make up the micronet, or where the gene had been temporarily blocked, it spent the same amount of time investigating its repeat visitor and its new visitor, showing that the mouse lacked social recognition skills. She found that, no matter what gene a mouse was missing, they showed the same impairment in social recognition.

The natural breakdown of this micronet in the wild can have serious implications. Choleris and Pfaff, in collaboration with Martin Kavaliers of the University of Western Ontario, have also shown it can lead to mice having a diminished ability to stay away from mice with parasites because socially aware mice distinguish between infected and uninfected males on the basis of odours, she said.

Understanding the genetic basis of social behaviour in mice could also help explain the neurobiological causes of human disorders that affect sociality, she said. “There are studies suggesting the oxytocin system may be impaired in people who suffer from autism.”

Elena Choleris
Department of Psychology , University of Guelph
(519) 824-4120, Ext. 52729, or

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