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Home > Facilities > Mass Spectrometry Facility > MS Services > Liquid Chromatography Mass Spectrometry

Small Molecule - Liquid Chromatography Mass Spectrometry

LC-MS can be used to profile and identify small molecules from a mixture. Idealy in water, ACN, MEOH, volatile buffers. Do not use or limit detergents, DMSO,DMF, high salt, non-volatile buffers or stabilizers.

Submit a minimum of 10 µl 0.1-1 mg/ml (approximately)

Submission form for high resolution LC-MS [1]

Submission form for small molecule MW high res [2] chemical formula confirmation

For More Information

Useful information about sample preparation:

Thermo LCMS Sample Preparation [3], Compound identification by MS [4]


Source URL:https://www.uoguelph.ca/aac/facilities/mass-spectrometry/services/small-molecule-liquid-chromatography-mass-spectrometry

Links
[1] https://www.uoguelph.ca/aac/facilities/mass-spectrometry/documents/submission-form-high-res-lc-ms-mw-2018 [2] https://www.uoguelph.ca/aac/submission-form-small-molecule-high-res-2018 [3] http://www.thermofisher.com/ca/en/home/industrial/mass-spectrometry/mass-spectrometry-learning-center/liquid-chromatography-mass-spectrometry-lc-ms-information/lc-ms-sample-preparation.html [4] https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/mas.21551