Sponsor
Ontario Institute for Cancer Research (OICR).
Program
OICR Cancer Therapeutics Innovation Pipeline
Description
The Cancer Therapeutics Innovation Pipeline (CTIP) Program was established to capitalize on Ontario’s expertise in cancer biology and drug discovery to create a pipeline of validated cancer targets and first-in-class or best-in-class, novel, selective lead molecules (small molecules or biologics) that would attract partnerships and/or investment for further preclinical and clinical development. To generate a sustainable pipeline, CTIP will support projects that aim to provide increasing evidence of target validation and disease association using functional assays and drug screening in relevant in vitro and in vivo models of the cancer type of interest.
CTIP funds projects in three stages of preclinical drug discovery and is currently inviting applications for the following two funding streams:
1. Early Accelerator projects: Delivers a validated primary assay to enable initial screening of molecules against a defined target. Entry into the EA stage requires evidence of target validation and association to the cancer of interest.
2. Late Accelerator projects: Delivers confirmed Hit molecules against a defined target, supported by evidence of disease association, using validated primary, secondary and orthogonal assays for screening. To achieve this goal, the project must describe an integrated testing cascade of experiments focused on achieving target validation in cell-based models coupled with medium-to-high-throughput screening for Hits.
Eligibility
OICR invites applications from investigators at Ontario academic centres, hospital research institutes, or other government research institutions. CTIP funding is only tenable in Ontario and can only be disbursed to not-for-profit entities.
For eligibility details, please review the program guidelines on the OICR website.
Funding Availability
Early Accelerator projects:
- Funding available: Up to $150,000 for up to one year.
Late Accelerator projects:
- Funding available: Up to $250,000 per year for up to two years.
Indirect Costs
OICR will provide up to thirty per cent with respect to eligible direct research expenses of the approved proposal to cover institutional overhead.
The host institution will not be eligible for reimbursement of overhead costs for the Projects/Sub Projects from any other Government of Ontario funds. If an overhead amount of less than 30 percent is requested, this must be detailed in the host institution Letter of Support as part of the proposal submission process.
Project Duration
Up to two years.
Special Notes
For an overview of the CTIP funding opportunity, consider attending a one-hour, virtual info session on June 15, 2021 from 1-2 p.m. ET. This session will be recorded and posted for viewing at a later date. Registration for the session can be found on the OICR funding opportunities page.
Please note that research activities carried out in the context of COVID-19 need to adhere to the University of Guelph COVID-19 research principles, policies, guidelines and processes as they may be updated from time to time and communicated on the Office of Research web-page.
Deadlines
If College-level review is required, your College will communicate its earlier internal deadlines.
| Type | Date | Notes |
|---|---|---|
External Deadline | Interested applicants are encouraged to attend the one-hour info session to learn more about this program. To register, please fill out the meeting registration form. | |
Internal Deadline | Please submit the completed LOI form along with a signed OR-5 form to research.services@uoguelph.ca. Please note: A Notice of Intent (NOI) must be submitted prior to gaining access to the full Letter of Intent (LOI) form. The information provided in the NOI can be updated prior to submitting the LOI. The deadline for submission of the NOI is the same as the deadline for LOI submission; however, applicants are encouraged to submit their NOI as early as possible to assist with planning. | |
External Deadline | Applicant to submit LOI using OICR's Grant Management System, ReportNet. Qualified applicants will be invited to submit a full application. Please inform research.services@uoguelph.ca if you are invited to submit a full application. | |
Internal Deadline | Please submit the full application package to research.services@uoguelph.ca | |
External Deadline | Applicant to submit full application using OICR's Grant Management System, ReportNet. |
How to Apply
Submissions are a three-step process, including a Notice of Intent (NOI), Letter of Intent (LOI), and a full application. NOIs, LOIs, and full applications are to be submitted online, using OICR’s Grant Management System ReportNet.
To register for an account, visit the OICR website. Existing ReportNet users should contact the OICR Scientific Secretariat to update their user profile to gain access to the funding opportunities. Once an account has been created, applicants can log into their account to view OICR funding opportunities and the associated RFAs (at the bottom of the screen under ‘Funding Opportunities’). Competitions which are currently accepting applications will have a green ‘Apply Now’ button. Use the ‘Apply Now’ button to initiate an application. The OICR Scientific Secretariat is available to help with any questions regarding the online process. Their contact information is provided below.
For information on the program requirements and submission process, please visit the OICR website.