William Tam
Professor
College of Computational, Mathematical and Physical Sciences, Department of Chemistry
Research Areas
- Organic Chemistry
Education
NSERC PDF (Harvard University, USA, 1997)
NSERC PDF (Imperial College, UK, 1996)
Ph.D. (University of Toronto, Canada, 1995)
B.Sc. (University of Hong Kong, 1990)
Research
The discovery and development of new chemical reactions is a major focus of research activity in organic chemistry. The classes of reactions which have found the broadest applicability in organic chemistry are those that address the issues of regio-, stereo- and enantiocontrol. Reactions which form multiple bonds, rings, and stereocenters are particularly important tools for the efficient assembly of complex molecular structures. The objective of our research program is to develop new methodologies in organic synthesis to construct complex organic molecules with high regio-, stereo- and enantiocontrol. Investigation on novel synthetic methodologies for the construction of different ring systems, including: nitrogen-containing heterocyclic compounds, spirocyclic compounds, attached-ring compounds and polycyclic compounds, is of particular interest. These ring systems are present in many biologically important natural products, which have found use in anti-HIV, anticancer, antiviral and antiretroviral researches.
Highlights
- The Use of Transition Metal Catalysts in Organic Synthesis
- Novel Cycloaddition Reactions
- The Chemistry of Bicyclic Alkenes
- Ring-forming and ring-opening reactions
- Synthesis of Novel Chiral Ligands & their Applications in Asymmetric Synthesis
- Studies on Remote Substituent Effects and Long-Range Stereoelectronic Effects
- Synthesis of Novel Organic Polymers
- Natural Product Synthesis
Past and Present Group Members
Current Group Members
Austin Pounder
(Ph.D. student)
Lina Ghulam
(M.Sc. student)
Fiona Bishop
(Undergraduate research student)
Katrina Ruzicka
(Undergraduate research student)
Krish Kiran Valluru
(Undergraduate research student)
Megan Farkas
(Undergraduate research student)
Cassandra Rooke
(Undergraduate research student)
Taylor Rounds
(Undergraduate research student)
Aritra Bhattacharjee
(Undergraduate research student)
Sebastian Karpinski
(Undergraduate research student)
Grace Kim
(Undergraduate research student)
Former Graduate Student Members
Samuel Koh (M.Sc. 2020)
Synthetic Chemist (Toronto Research Chemicals)
Angel Ho (M.Sc. 2020)
Synthetic Chemist (Toronto Research Chemicals)
Christopher Wicks (M.Sc. 2019)
Ph.D. student (Brock Univ. with Tomas Hudlicky)
Dina Petko (M.Sc. 2018)
Chemist (Fluidigm Canada Inc.)
Katrina Tait (M.Sc. 2017)
Research Scientist (Wellington Labs)
Rebecca Boutin (M.Sc. 2017)
Ph.D. student (McGill Univ. with Youla Tsantrizos)
Emily Carlson (Ph.D. 2016)
Product Specialist (PerkinElmer Technologies)
Previous:
- Research Chemist (Mirexus Biotechnologies Inc.)
Jaipal R. Nagireddy (Ph.D. 2014)
Director (Vibrant Pharma Inc.)
Michael Edmunds (M.Sc. 2014)
Epidemiologist/Biostatistician (Health Canada)
Previous:
- Chemist (Lab Services, U of G)
Mary McKee (M.Sc. 2013)
Account Manager (Advanced Chemistry Development Inc.)
Previous:
- Chemist (Toronto Research Chemicals)
Mohammed A. Raheem (Ph.D. 2013)
Research Chemist (Apotex Pharmachem Inc.)
Kelsey Jack (M.Sc. 2012)
Registered Physiotherapist (BodyTech Physiotherapy)
Previous:
- Chemist (Apotex Pharmachem Inc.)
Andrew Tigchelaar (M.Sc. 2012)
Law Clerk (Federal Court of Canada)
Previous:
- Chemist (Lab Services, U of G)
Tanner Kettle (M.Sc. 2012)
Quality Assurance Manager (Acerus Pharma)
Previous:
- Quality Associate (Trimel Pharmaceuticals)
Jamie Haner (M.Sc. 2011)
Ph.D. student (McMaster U with Gary Schrobilgen)
Robin Durham (M.Sc. 2011)
High School Teacher (Abbey Park High School)
Ben Machin (M.Sc. 2009)
Senior Research Scientist (Alphora Research Inc.)
Jordan Goodreid (M.Sc. 2009)
Senior Research Scientist (Alphora Research Inc.)
Neil Cockburn (M.Sc. 2009)
Radiochemist (Lawson Health Research Institute)
Michelle Menard (M.Sc. 2008)
Business Coach (Ultimate Life Satisfaction Inc.)
Previous:
- Assistant Manager (MAC Cosmetics)
Paul Le Marquand (M.Sc. 2007)
High School Teacher (St. Joan of Arc School Calgary)
Ryan Burton (M.Sc. 2007)
Analytical Technologist (Ministry of the Environment)
Previous:
- Associate Chemist II (Apotex Pharmachem Inc.)
- Research Chemist (Alphora Research Inc.)
Anna Allen (M.Sc. 2007)
Assistant Professor (Colorado State University, USA)
Previous:
- Postdoc. at Cambridge U with Matthew Gaunt
- Ph.D. at Princeton U with David MacMillan
Gavin C. Tsui (M.Sc. 2006)
Faculty (The Chinese University of Hong Kong)
Previous:
- Postdoc. at Max-Planck-Institut with Ben List
- Ph.D. at U of Toronto with Mark Lautens
Karine Villeneuve (Ph.D. 2006)
Director CMC (Bellus Health Inc.)
Previous:
- Research Fellow (Vertex Canada)
- Vice President Product Development (Groupe PARIMA)
- Research Chemist (Delmar Chemicals)
- Research Chemist (Merck Frosst Canada)
- Postdoc. at UC Irvine with Larry Overman
Nicole R. Riddell (M.Sc. 2005)
Quality manager (Wellington Labs)
Woo-Jin Yoo (M.Sc. 2005)
Assistant Professor (National Taiwan University)
Previous:
- Assistant Professor (University of Tokyo)
- Postdoc. at U of Tokyo with Kobayashi
- Ph.D. at McGill U with Chao-Jun Li
Robert W. Jordan (Ph.D. 2004)
Senior Manager of Technology Transfer (Eurofins CDMO Alphora Research Inc.)
Previous:
- Senior Research Scientist (Alphora Research Inc.)
- Senior Scientist (Vibrant Pharma Inc.)
Geoffrey K. Tranmer (Ph.D. 2003)
Associate Professor (University of Manitoba)
Previous:
- Research Chemist (Merck Frosst Canada)
- Postdoc. at Cambridge U with Steve Ley
- Postdoc. at Princeton U with Semmelhack
Peter R. Khoury (M.Sc. 2003)
Owner of IGET Chemicals
Peter D. M. Mayo (Ph.D. 2003)
Insect Chemical Ecologist (Canadian Forest Service)
Carol Yip (M.Sc. 2000)
Patent Agent (Deacons Law Firm)
Previous:
- Patent Agent (Bereskin & Parr Law Firm)
Undergraduate: Senior Research Projects
Jarvis Hill (2018-2019)
Ph.D. student (University of Georgia)
Austin Pounder (2018-2019)
M.Sc. student (Tam group, U of Guelph)
Isaak Mele (2018-2019)
Senior Associate (Sun Life Capital Management)
Meghan Fragis (2017-2018)
Ph.D. student (McMaster University)
Samuel Koh (2017-2018)
M.Sc. student (Tam group, U of Guelph)
Elizabeth Brown (2017-2018)
Analyst (Labstat International Inc.)
Alysia Horvath (2016-2017)
Quality Control Chemist (Bio Agri Mix LP)
Austin Marchese (2016-2017)
Ph.D. student (University of Toronto)
Matthew Stratton (2016-2017)
Dentistry Student (University of Detroit)
Michael Saley (2016-2017)
Ph.D. student (University of Guelph)
Mohamed Ahmed (2014-2015)
Medical School student (University of Toronto)
Daniel Hong (2014-2015)
Senior Regulatory Affairs Officer (Health Canada)
Cristina Barros (2014-2015)
Katrina Tait (2014-2015)
Research Scientist (Wellington Labs)
Scott McKenzie (2011-2012)
Chemist (Lorama Group Inc.)
Mary McKee (2011-2012)
Account Manager (Advanced Chemistry Development Inc.)
David Petrone (2010-2011)
Postdoctoral Fellow (U of Toronto)
Colin Hesp (2010-2011)
Pharmacist (Rexall Pharmacies)
Jacqueline Evans (2009-2010)
Dentist (Dentistry on Kent in Lindsay)
Jamie Haner (2008-2009)
Ph.D. student (McMaster U with Gary Schrobilgen)
Nick Uhlig (2008-2009)
Research Scientist (Gilead Sciences Inc.)
Adrian Millman (2007-2008)
Medical School student (University of Calgary)
Avila De Sousa (2007-2008)
High School Teacher (North Toronto Collegiate Institute)
Robin Durham (2007-2008)
High School Teacher (Abbey Park High School)
Neil Cockburn (2006-2007)
Radiochemist (Lawson Health Research Institute)
John Whitney (2006-2007)
Assistant Professor (McMaster University)
Paul Le Marquand (2005-2006)
High School Teacher (St. Joan of Arc School Calgary)
Anna Allen (2004-2005)
Assistant Professor (Colorado State University, USA)
Stephen Kibbee (2004-2005)
Principal (Sandy Lake Academy)
Laura New (2004-2005)
Research Associate (University of Guelph)
Gavin Tsui (2003-2004)
Assistant Professor (The Chinese University of Hong Kong)
Erika Cady (2002-2003)
Engineering Professional (Bombardier Aerospace)
Woo-Jin Yoo (2002-2003)
Assistant Professor (National Taiwan University)
Stuart Hudson (2001-2002)
Nathan Dalgleish (2000-2001)
Territory Manager (Diamed Lab Supplies)
Robert Jordan (1999-2000)
Senior Manager of Technology Transfer (Eurofins CDMO Alphora Research Inc.)
Jan Rainey (1998-1999)
Full Professor (Dalhousie University)
Marc Poirier (1998-1999)
Terminal Manager (Manitoulin Transport)
Peter Keech (1998-1999)
Manager Engineered Barrier Science (Nuclear Waste Management Organization)
Sean Handerson (1998-1999)
Craig Humber (1998-1999)
Oral Surgeon (Saskatoon Oral Surgery)
Undergraduate: Summer USRA/URA
Matthew MacLeod (2019S)
B.Sc. student (U of Guelph)
Austin Pounder (2019S)
M.Sc. student (Tam group, U of Guelph)
Samuel Koh (2018S)
M.Sc. student (Tam group, U of Guelph)
Mohamed Ahmed (2016S)
Medical School student (University of Toronto)
Katrina Tait (2015S)
Research Scientist (Wellington Labs)
Oday Alrifai (2014S)
Ph.D. student (Food Science, U of Guelph)
Amanda Sproule (2013S)
Chemistry Research Technician (Agriculture and Agri-Food Canada)
Cassandra Quan (2012S)
Medical Doctor (in Brampton)
Colleen Hillis (2011S)
Quality Specialist (McNeil Consumer Healthcare)
Jennifer Howell (2008S)
High School Teacher (IB DP Chemistry, Elmwood School)
Elizabeth Fatila (2007S)
Assistant Professor (Louisiana Tech University, USA)
Melody Ng (2006S)
Medical Doctor (North York General Hospital)
Steve Kibbee (2004S)
Principal (Sandy Lake Academy)
Cheryl Cassidy (2002S & 2003S)
Medical Doctor (Hanover and District Hospital)
Sarah Pang (2001S)
Maria Madeira (2000S)
Principal Scientist (Merck)
Tahmina Kamal (1999S)
English Teacher (Bellevue Learning Center)
Linda Chee-Chue (1998S)
Chemist (Health Canada)
Undergraduate: Work Study Program
Paulina Kmiec (2018-2019)
B.Sc. student (U of Guelph)
Grace Shei (2017-2018)
M.Sc. student (U of Guelph)
Grace Teng (2017-2018)
M.Sc. student (U of Guelph)
Austin Blue (2017-2018)
Retail Store Clerk (Sleeman Breweries Ltd.)
Elaine Li (2017-2018)
Pharmacy Assistant (Chiron Compounding Pharmacy)
Naomi Wedel (2017-2018)
Medical School Student (Queen's University)
Maria Berliant (2016-2017)
Medical School Student (University of Ottawa)
Jessica Purbrick (2016-2017)
Medical School Student (University of Toronto)
Valerei Wai (2015-2017)
Research Assistant (NuBiyota)
Nicole McKenney (2014-2016)
Optometry Student (University of Waterloo)
Kristen Sauerzopf (2014-2016)
Clinical Research Study Assistant (University Health Network)
Brieanne MacKay (2014-2015)
Vet School Student (University of Guelph)
Milena Music (2014-2015)
Medical School Student (University of Toronto)
Katie Phillips (2014-2015)
QC Analyst (GlaxoSmithKline)
Katie Teng (2014-2015)
Ph.D. student (McGill University)
Natalie Montwill (2013-2014)
Process Development Scientist (Eurofins DiscoverX)
Nichole McKay (2012-2013)
Clinical Research Coordinator (LMC Manna Research)
Krista McCambridge (2012-2013)
Registered Nurse (Sanguen Health Centre)
Jessa Letargo (2012-2013)
Catherine Belanger (2012-2013)
Veterinarian (Niagara Veterinary Emergency Clinic)
Alex Chan (2011-2012)
Youth Pastor (Richmond Hill Christian Community Church)
Patricia Sobczyk (2009-2010)
Genje Buenviaje (2009-2010)
Medical School Student (James Cook University)
Jee Lee (2007-2008)
Fraser Waldie (2006-2007)
Research Scientist (NOVA Chemicals)
Karan Tsoi (2006-2007)
Assistant General Manager (Terre Rouge Restaurant)
Tracy Ng (2006-2007)
Sarah Regli (2005-2006)
High School Teacher (St. John's Kilmarnock School)
Yousuf Keria (2005-2006)
Jenna Denyes (2005-2006)
Senior Healthcare Analyst Director (GAM Investments)
Jamie Lee (2005S)
Natalia Kulikova (2005S)
Owner (Chemia Academic Editing)
Alex Perieteanu (2003-2004)
Director (Biopharmaceutical Services at SGS Life Science)
Robert McPhail (2002-2003)
Analyst (Biopharmaceutical Services at SGS Life Science)
Kathryn Towns (2000-2001)
Matt Wong (2000-2001)
Adam Pyke (2000-2001)
Scientist (ExVivo Labs Inc.)
Tiffany Hecnar (1999-2000)
Laboratory & Biosafety Officer (Lakehead University)
Others
Catherine Fust (Undergraduate Research Volunteer, 2019-2020)
B.Sc. student ( University of Guelph)
Mikaela Almeida (Undergraduate Research Volunteer, 2018-2019)
B.Sc. student ( University of Guelph)
Danielle Corco (Undergraduate Research Volunteer, 2017-2018)
Vet School Student (University of Guelph)
Elham Karimi (Postdoctoral Research Fellow, 2007-2008)
Technical Manager (Syncoat Chemicals Ltd.)
Alex Erokhine (Postdoctoral Research Fellow, 2001-2002)
Publications
2021
151. Austin Pounder, Angel Ho, Matthew Macleod and William Tam*
"Chemistry of Unsymmetrical C1-Substituted Oxabenzonorbornadienes"
Curr. Org. Syn. 2021, 18, 446–474.
150. Austin Pounder, Leanne D. Chen*, and William Tam
"The Mechanism and Origin of Enantioselectivity in the Rhodium-Catalyzed Asymmetric Ring-Opening Reactions of Oxabicyclic Alkenes with Organoboronic Acids: A DFT Investigation"
Organometallics 2021, 40, 1588–1597.
149. Austin Pounder, Fiona Bishop, Leanne D. Chen*, and William Tam*
"A DFT Study on the Mechanism and Origin of Regioselectivity in the Rhodium/Diene-Catalyzed Ring-Opening Reactions of C1-Substituted Oxabenzonorbornadienes with Arylboronic Acids"
Eur. J. Org. Chem. 2021, 1901–1908.
148. Austin Pounder, Leanne D. Chen,* and William Tam*
"Ruthenium-Catalyzed [2 + 2] versus Homo Diels−Alder [2 + 2 + 2] Cycloadditions of Norbornadiene and Disubstituted Alkynes: A DFT Study"
ACS Omega 2021, 6, 900-911.
2020
147. Samuel Koh, Austin Pounder, Elizabeth Brown and William Tam*
"Intramolecular Nickel-Catalyzed Ring-Opening Reactions of Oxabenzonorbornadienes with C1-Tethered Aryl Halides: An Improvement of Method"
Eur. J. Org. Chem. 2020, 4558-4562.
146. Samuel Koh, Austin Pounder, Elizabeth Brown and William Tam*
"Intramolecular Palladium-Catalyzed Ring Opening of Oxabenzonorbornadienes with C1-Tethered Aryl Halides"
Org. Lett. 2020, 22, 3433–3437.
145. Nawaz Ahmed, Behnoush Kermanshahi, Saeed M. Ghazani, Katrina Tait, Matthew Tcheng, Alessia Roma, Shannon P. Callender, Richard W. Smith, William Tam,, Shawn D. Wettig, Michael A. Rogers , Alejandro G. Marangoni & Paul A. Spagnuolo*
"Avocado-derived polyols for use as novel co-surfactants in low energy self-emulsifying microemulsions"
Scientific Reports - Nature 2020, 10, 5566.
144. Alan J. Lough, Samuel Koh and William Tam*
"12,15-Dimethyl-8-oxatetracyclo[8.8.0.02,7.011,16]-octadeca-1(18),2,4,6,11(16),12,14-heptaen-10-ol"
IUCrData 2020, 5, x200315.
143. Alan J. Lough, Austin Pounder, Christopher Wicks and William Tam*
"1,2,3,5-Tetrahydronaphtho[2,1-c]oxepine"
IUCrData 2020, 5, x200288.
142. Alan J. Lough, Austin Pounder and William Tam*
"12-Ethyl-6a,10a-dihydro-5H-6-oxachrysene"
IUCrData 2020, 5, x200286.
141. Alan J. Lough, Angel Ho and William Tam*
"[(1R*,3S*,4S*)-3-(2-Hydroxybenzoyl)-1,2,3,4-tetrahydro-1,4-epoxynaphthalen-1-yl]methyl 4-nitrobenzoate"
IUCrData 2020, 5, x200265.
2019
140. Christopher Wicks, Samuel Koh, Austin Pounder, Emily Carlson, and William Tam*
"Acid-Catalyzed Intramolecular Ring-Opening Reactions of Cyclopropanated Oxabenzonorbornadienes with Alcohol Nucleophiles"
Tetrahedron Lett. 2019, 60, article 151228.
139. Dina Petko, Austin Pounder and William Tam*
"Ruthenium-Catalyzed [2+2+2] Bis-Homo-Diels Alder Cycloadditions of 1,5-Cycloocatadiene with Alkynyl Phosphonates"
Synthesis 2019, 51, 4271–4278.
138. Dina Petko, Matthew Stratton, Samuel Koh and William Tam*
"Cationic Ruthenium-Catalyzed Bis-Homo-Diels-Alder Cycloaddition"
Curr. Org. Syn. 2019, 16, 787–792.
137. Jarvis Hill, Christopher Wicks, Austin Pounder and William Tam*
"Iridium Catalyzed Ring-Opening Reactions of Unsymmetrical Oxabenzonorbornadienes with Water and Alcohol Nucleophiles"
Tetrahedron Lett. 2019 60, article 150990.
136. Dina Petko, Samuel Koh and William Tam*
"Transition Metal-Catalyzed Reactions of Alkynyl Halides"
Curr. Org. Syn. 2019, 16, 546–582.
135. Rebecca Boutin, Samuel Koh and William Tam* (Invited Review)
"Recent Advances in Transition Metal-Catalyzed Reactions of Oxabenzonorbornadiene"
Curr. Org. Syn. 2019, 16, 460–484.
134. Jarvis Hill and William Tam*
"Palladium/Lewis Acid Co-Catalyzed Ring-Opening Reactions of Unsymmetrical Oxabenzonobornadienes with Oximes"
J. Org. Chem. 2019 84, 8309–8314.
133. Alan J. Lough, Jarvis Hill and William Tam*
"1-[(1R*,2R*)-1,2-Dihydroxy-1,2-dihydronaphthalen-1-yl]ethan-1-one"
IUCrData 2019, 4, x190609.
132. Katrina Tait, Samuel Koh, Nicolas Blanchard and William Tam*
"Ruthenium-Catalyzed Ring-Opening Reaction of a 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene with Amines – An Unexpected Mode of Ring-Opening"
Can. J. Chem. 2019, 97, 310–316.
2018
131. Dina Petko, Matthew Stratton and William Tam*
"Ruthenium-catalyzed Bis-Homo-Diels-Alder Reaction: Searching for Commercially Available Catalysts and Expanding the Scope of Reaction"
Can. J. Chem. 2018, 96, 1115–1121.
130. Emily Carlson, Rebecca Boutin and William Tam*
"Type 3 ring opening reaction of cyclopropanated oxabenzonorbornadienes with alcohol nucleophiles"
Tetrahedron 2018, 74, 5510–5518.
129. Katrina Tait and William Tam*
"Transition Metal-Catalyzed Reactions of 3-Aza-2-oxabicyclo[2.2.1]hept-5-enes"
Curr. Org. Syn. 2018, 15, 762–780.
2017
128. Katrina Tait, Alysia Horvath, Nicolas Blanchard and William Tam* "Acid-catalyzed ring-opening reactions of a cyclopropanated 3-aza-2-oxabicyclo[2.2.1]hept-5-ene with alcohols" Beilstein J. Org. Chem. 2017, 13, 2888–2894.
127. Alan J. Lough, Katrina Tait, Alysia Horvath and William Tam* "N-(1R,2R,4R,5S)-rel-4-tert-Butoxybicyclo[3.1.0]hex-2-yl(hydroxyamino) 2,2-dimethylpropionate" IUCrData 2017, 2, x171419.
126. Alan J. Lough, Katrina Tait and William Tam* "tert-Butyl (3-oxocyclopentyl)carbamate" IUCrData 2017, 2, x171418.
125. Alan J. Lough, Emily Carlson and William Tam* “(5R, 6R)-rel-9-tert-butyl-trans-5,6-dimethoxy-6,7-dihydro-5H-benzocycloheptene” IUCrData 2017, 2, x171417.
2016
124. Katrina Tait, Oday Alrifai, Rebecca Boutin, Jamie Haner and William Tam*.
“Palladium-catalyzed Ring-Opening Reactions of Cyclopropanated 7-Oxabenzonorbornadiene with Alcohols”
Beil. J. Org. Chem. 2016, 12, 2189–2196.
123. Emily Carlson, Daniel Hong and William Tam*.
“Type 2 Ring-Opening Reactions of Cyclopropanated 7-Oxabenzonorbornadienes with Carboxylic Acid Nucleophiles”
Synthesis 2016, 48, 4253–4259.
122. Emily Carlson and William Tam*
“Synthesis of Cyclopropanated 7-Azabenzonorbornadienes”
Synthesis 2016, 48, 2449–2454.
121. Emily Carlson and William Tam*
“Type 1 Ring-Opening Reactions of Cyclopropanated 7-Azabenzonorbornadienes with Organocuprates”
Org. Lett. 2016, 18, 2134–2137.
120. Alan J. Lough, Emily Carlson and William Tam*
“(1aR, 2R, 7S, 7aS)-rel-1a,2,7,7a-Tetrahydro-3,6-dimethoxy-2-methyl-2,7-epoxy-1H-cyclopropa[b]naphthalene”
IUCrData 2016, x160341.
119. Michael Edmunds, Mohammed Abdul Raheem, Rebecca Boutin, Katrina Tait and William Tam*. 2016.
“Regioselective palladium catalyzed ring-opening reactions of C1 substituted oxabicyclo[2,2,1]hepta-2,5-diene-2,3-dicarboxylates”
Beil. J. Org. Chem. 2016, 12, 239–244.
118. Emily Carlson, Guillaume Duret, Nicolas Blanchard, and William Tam*
“Synthesis of Cyclopropanated [2.2.1] Heterobicycloalkenes: An Improved Procedure”
Synth. Commun. 2016, 46, 55–62.
2015
117. Michael Edmunds, Michelle L. Menard and William Tam*
“Study on the Regioselectivity of Rhodium-Catalyzed Ring Opening Reactions of C1 Substituted 7-Oxabenzonorbornadienes with Boronic Acids”
Synth. Commun. 2015, 45, 468–476.
2014
116. Jordan Goodreid, Karine Villeneuve, Emily Carlson and William Tam*.
“Ruthenium-Catalyzed Asymmetric [2+2] Cycloadditions between Chiral Acetylenic Acyl Camphorsultam-Substituted Alkynes and Bicyclic Alkenes”
J. Org. Chem. 2014, 79, 10002–10012.
115. Jaipal R. Nagireddy, Geoffrey K. Tranmer, Emily Carlson and William Tam*.
“N-O Cleavage reactions of bicycloalkene-fused 2-isoxazolines”
Beil. J. Org. Chem. 2014, 10, 2200–2205.
114. Andrew Tigchelaar, Jamie Haner, Emily Carlson, and William Tam*.
“Type 2 Ring-Opening Reactions of Cyclopropanated 7-Oxabenzonorbornadienes under Acid Catalysis”
Synlett 2014, 25, 2355–2359.
113. Gavin C. Tsui, Karine Villeneuve, Emily Carlson and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions between Norbornene and Propargylic Alcohols or their Derivatives”
Organometallics 2014, 33, 3847–3856.
112. Jaipal R. Nagireddy, Emily Carlson and William Tam*.
“1,3-Dipolar cycloaddition of C1-substituted 7-oxabenzonorbornadienes”
Can. J. Chem. 2014, 92, 1053–1058.
111. Mohammed Abdul Raheem, Michael Edmunds, William Tam*.
“Regioselective Palladium Catalyzed Ring-opening Reactions of C1 substituted Oxabenzonorbornadienes”
Can. J. Chem. 2014, 92, 888–895.
110. Jaipal R. Nagireddy, Emily Carlson, William Tam*.
“1,3-Dipolar Cycloadditions of Nitrile Oxides with 7-Oxa- and 7-Azabenzonorbornadienes”
Can. J. Chem. 2014, 92, 635–639.
109. Alan J. Lough, Mohammed-Abdul Raheem and William Tam.
“cis-2-(4-Methoxyphenyl)-4-methyl-1,2-dihydronaphthalen-1-ol”
Acta Cryst. 2014, E70, o546.
108. Alan J. Lough, Jaipal Nagireddy and William Tam.
“1-(3-Hydroxy-5,8-dimethoxy-4-methyl-1,2,3,4-tetrahydro-1,4-epoxynaphthalen-2-yl)ethan-1-one”
Acta Cryst. 2014, E70, o545.
107. Alan J. Lough, Jaipal Nagireddy and William Tam.
“5,8-Dimethoxy-3,9-dimethyl-3a,4,9,9a-tetrahydro-4,9-epoxynaphtho[2,3-d ]isoxazole”
Acta Cryst. 2014, E70, o544.
106. Alan J. Lough, Jaipal Nagireddy and William Tam.
“(3-Methyl-3a,4,7,7a-tetrahydro-5H-4,7-methanoisoxazolo[4,5-d ][1,2]oxazin-5-yl)(phenyl)methanone”
Acta Cryst. 2014, E70, o543.
105. Emily Carlson, Jamie Haner, Mary McKee and William Tam*
“Type 1 Ring-Opening Reactions of Cyclopropanated 7-Oxabenzonorbornadienes with Organocuprates”
Org. Lett. 2014, 16, 1776–1779.
104. Mary McKee, Jamie Haner, Emily Carlson and William Tam*.
“Synthesis of Cyclopropanated 7-Oxabenzonorbornadienes”
Synthesis 2014, 46, 1518–1524.
2013
103. Kelsey Jack, Ben Machin, Andrew Tigchelaar and William Tam*.
“Synthesis of Substituted Norbornadienes.”
Curr. Org. Syn. 2013, 10, 584–630.
102. Kelsey Jack and William Tam*.
“Ruthenium-Catalyzed Dimerization of 7-Oxabicyclo[2,2,1]hepta-2,5-diene-2,3-dicarboxylates.”
J. Org. Chem. 2013, 78, 3416–3420.
101. Kelsey Jack, Elisabeth Fatila, Colleen Hillis and William Tam*.
“Ruthenium-Catalyzed Nucelophilc Ring-Opening Reactions of 7-Oxabenzonorbornadienes with Methanol.”
Synth. Commun. 2013, 43, 1181–1187.
100. Kelsey Jack, Jordan Goodreid, Neil Cockburn and William Tam*. (invited Book Chapter)
“Transition Metal-Catalyzed [2+2] Cycloaddition Reactions Between Bicyclic Alkenes and Alkynes.” in “Advances in Organic Synthesis”, Editor: Atta-ur-Rahman, Bentham Science Publishers. 2013, Vol. 6, Chapter 2, pp. 59–114.
99. Mohammed-Abdul Raheem and William Tam*.
“Synthesis of C1-Substituted 7-Oxanorbornadienes.”
Synth. Commun. 2013, 43, 260–267.
2012
98. Andrew Tigchelaar and William Tam*.
“Iridium-Catalyzed Intramolecular [4+2] Cycloadditions of Alkynyl Halides”
Beil. J. Org. Chem. 2012, 8, 1765–1770.
97. Alan J. Lough, Kelsey Jack and William Tam.
“Hexamethyl 13,14-dioxapentacyclo[8.2.1.14,7.02,9.03,8]tetradeca-5,11-diene-1,4,5,6,11,12-hexacarboxylate”
Acta Cryst. 2012, E68, o2963.
96. Alan J. Lough, Kelsey Jack and William Tam.
“Tetra-tert-butyl 13,14-dioxapentacyclo[8.2.1.14,7.02,9.03,8]tetradeca-5,11-diene-5,6,11,12-tetracarboxylate”
Acta Cryst. 2012, E68, o2962.
95. Alan J. Lough, Kelsey Jack and William Tam.
“Tetramethyl 1,4-dimethyl-13,14-dioxapentacyclo[8.2.1.14,7.02,9.03,8]tetradeca-5,11-diene-5,6,11,12-tetracarboxylate”
Acta Cryst. 2012, E68, o2961.
94. Jamie Haner, Kelsey Jack, Michelle L. Menard, Jennifer Howell, Jaipal Nagireddy, Mohammed Abdul Raheem and William Tam*.
“Synthesis of C1-Substituted Oxabenzonorbornadienes”
Synthesis 2012, 44, 2713–2722.
2011
93. Robin Durham, Jérémie Mandel, Nicolas Blanchard, and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloaddition Reactions of a 2-Oxa-3-azabicyclo[2.2.1]hept-5-ene with Unsymmetrical Alkynes.”
Can. J. Chem. 2011, 89, 1494–1505.
92. Tanner K. Kettles and William Tam*. (Invited Review)
“7-tert-Butoxy-Bicyclo[2.2.1]hepta-2,5-diene.”
In “Encyclopedia of Reagents for Organic Synthesis”, Editors: Crich, D.; Fuchs, P. L.; Charette, A. B.; Rovis, T., John Wiley & Sons Ltd., 2011, article number RN01412.
91. Tanner K. Kettles and William Tam*. (Invited Review)
“Bicyclo[2.2.1]hepta-2,5-diene (Norbornadiene) (Unique ID RN01411).”
In “Encyclopedia of Reagents for Organic Synthesis”, Editors: Crich, D.; Fuchs, P. L.; Charette, A. B.; Rovis, T., John Wiley & Sons Ltd., 2011, article number RN01411.
90. Jaipal R. Nagireddy, Mohammed-Abdul Raheem, Jamie Haner and William Tam*.
“Methods of Cleavage of 2-Isoxazolines.”
Curr. Org. Syn. 2011, 8, 659–700.
89. Tanner J. Kettles, Neil Cockburn and William Tam*.
“Ruthenium-Catalyzed Homo Diels-Alder [2+2+2] Cycloadditions of Alkynyl Phosphonates with
Bicyclo[2.2.1]hepta-2,5-diene.”
J. Org. Chem. 2011, 76, 6951–6957.
88. Alan J. Lough, David A. Petrone and William Tam.
“(1S,2S,4R)-7-tert-Butoxybicyclo[2.2.1]hept-5-en-2-yl (2S)-2-(6-methoxynapthalen-2-yl)propanoate.”
Acta Cryst. 2011, E67, o1848.
87. Jamie Haner, Kelsey Jack, Jaipal R. Nagireddy, Mohammed-Abdul Raheem, Robin Durham and William Tam*.
“Synthesis of 2-Substituted Furans by Iron- and Palladium-Catalyzed Coupling Reactions”
Synthesis 2011, 731–738.
2010
86. Neil Cockburn and William Tam*.
“Bicyclic Alkenes: From Cycloadditions to the Discovery of New Reactions.”
Synlett. 2010, 1170–1189.
85. Mohammed-Abdul Raheem, Jaipal R. Nagireddy, Robin Durham and William Tam*.
“Efficient Procedure for the Preparation of 2-Bromofuran and its Application in the Synthesis of 2-Arylfurans.”
Synth. Commun. 2010, 40, 2138–2146.
2009
84. Jordan D. Goodreid, Michael C. Jennings* and William Tam.
“Asymmetric ruthenium-catalysed [2+2] cycloadditions between bicyclic alkenes and chiral aryl-
substituted acetylenic acyl camphorsultam alkynes”
Acta Cryst. 2009, C65, o649–o652.
83. Melissa Ballantine, Michelle L. Menard and William Tam*.
“Isomerization of 7-Oxabenzonorbornadienes into Naphthols Catalyzed by [RuCl2(CO)3]2.”
J. Org. Chem. 2009, 74, 7570–7573.
82. Ben P. Machin, Melissa Ballantine, Jérémie Mandel, Nicolas Blanchard and William Tam*
“Rhodium-Catalyzed Ring Opening Reactions of a 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene with Arylboronic Acids.”
J. Org. Chem. 2009, 74, 7261–7266.
81. Neil Cockburn, Elham Karimi and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions of Bicyclic Alkenes with Alkynyl Phosphonates”
J. Org. Chem. 2009, 74, 5762–5765.
80. Jordan Goodreid, Neil Cockburn and William Tam*.
“Transition Metal-Catalyzed [2+2] Cycloaddition Reactions Between Bicyclic Alkenes and Alkynes”
Curr. Org. Syn. 2009, 6, 219–238.
79. Alan J. Lough, Ben P. Machin and William Tam.
“tert-Butyl N-hydroxy-N-[(1S*,2R*)-2-(1-naphthyl)cyclopent-3-en-1-yl]carbamate.”
Acta Cryst. 2009, E65, o1481.
78. Ben P. Machin, Jennifer Howell, Jérémie Mandel, Nicolas Blanchard and William Tam*
“Ruthenium-Catalyzed Nucleophilic Ring-Opening Reactions of a 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene with Alcohols”
Org. Lett. 2009, 11, 2077–2080.
77. Jennifer Howell, John D. Goddard* and William Tam.
“A relative approach for determining ring strain energies of heterobicyclic alkenes”
Tetrahedron 2009, 65, 4562–4568.
76. Gavin C. Tsui, Paul Le Marquand, Anna Allen and William Tam*.
“Synthesis of anti-2,7-Disubstituted Norbornadienes”
Synthesis 2009, 609–619.
2008
75. Paul Le Marquand, Gavin C. Tsui, John C. C. Whitney and William Tam*.
“Iron-Catalyzed Cross-coupling Reactions Between a Bicyclic Alkenyl Triflate and Grignard Reagents”.
J. Org. Chem. 2008, 73, 7829–7832.
74. Anna Allen, Karine Villeneuve, Neil Cockburn, Elisabeth Fatila, Nicole Riddell and William Tam*.
“Alkynyl Halides in Ruthenium(II)-Catalyzed [2+2] Cycloadditions of Bicyclic Alkenes”
Eur. J. Org. Chem. 2008, 4178–4192.
73. Paul Le Marquand and William Tam*.
“Enantioselective Palladium-Catalyzed [3+2] Trimethylenemethane Cycloadditions”
Angew. Chem. Int. Ed. 2008, 47, 2926–2928.
72. Robert W. Jordan, Paul Le Marquand and William Tam*.
“Ruthenium(II)-Catalyzed [2+2] Cycloadditions of anti 7-Substituted Norbornenes”
Eur. J. Org. Chem. 2008, 80–86.
2007
71. Karine Villeneuve and William Tam*.
“Construction of Isochromenes via Ruthenium-Catalyzed Reaction of Oxabenzonorbornenes with Propargylic Alcohols”
Organometallics 2007, 26, 6082–6090.
70. Anna Allen, Paul Le Marquand, Ryan Burton, Karine Villeneuve and William Tam*.
“Rhodium-Catalyzed Asymmetric Cyclodimerization of Oxabenzonorbornadienes and Azabenzonorbornadienes: Scope and Limitations”
J. Org. Chem. 2007, 72, 7849–7857.
69. Ryan R. Burton and William Tam*.
“Study on the Reactivity of Oxabicyclic Alkenes in Ruthenium-Catalyzed [2+2] Cycloadditions”
J. Org. Chem. 2007, 72, 7333–7336.
68. Ryan R. Burton, William Tam*.
“Ruthenium(II)-Catalyzed Cyclization of Azabenzonorbornadienes with Alkynes”
Org. Lett. 2007, 9, 3287–3290.
67. Alan J. Lough*, Anna Allen and William Tam.
“Cyclodimerization product of benzooxanorbornadiene.”
Acta Cryst. 2007, E63, o1462–o1463.
66. Peng Liu, William Tam and John D. Goddard*.
“Ruthenium Catalyzed [2+2] Cyloadditions between Substituted Alkynes and Norbornadiene:
A Theoretical Study.”
Tetrahedron, 2007, 63, 7659–7666.
2006
65. Karine Villeneuve and William Tam*.
“Ruthenium(II)-Catalyzed Cyclization of Oxabenzonorbornenes with Propargylic Alcohols: Formation of Isochromenes.”
Eur. J. Org. Chem. 2006, 5449–5453.
64. Ryan R. Burton and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions Between C1-Substituted 7-Oxanorbornadienes and Alkynes.”
Tetrahedron Lett. 2006, 47, 7185–7189.
63. Robert W. Jordan, Karine Villeneuve and William Tam*.
“Study on the Reactivity of the Alkyne Component in Ruthenium-Catalyzed [2+2]
Cycloadditions between an Alkene and an Alkyne.”
J. Org. Chem. 2006, 71, 5830–5833.
62. Alan J. Lough*, Karine Villeneuve and William Tam.
“Absolute configuration of the p-nitrobenzoate ester of the cycloadduct of ( S)-4-hydroxy-2-
pentynoate and acetic acid-8-acetoxy-1,4-dihydro-1,4-methanonapththalen-5-yl ester.”
Acta Cryst. 2006, E62, o2846–o2847.
61. Alan J. Lough*, Karine Villeneuve and William Tam.
“Ethyl 2-acetonyl-3-(1H-isochromen-1-yl)acrylate.”
Acta Cryst. 2006, E62, o2582–o2583.
60. Peng Liu, Robert W. Jordan, John D. Goddard* and William Tam*.
“Remote Substituent Effects in Ruthenium-Catalyzed [2+2] Cycloadditions: An Experimental
and Theoretical Study.”
J. Org. Chem. 2006, 71, 3793–3803.
59. Karine Villeneuve, Nicole Riddell and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions of Bicyclic Alkenes and Ynamides.”
Tetrahedron 2006, 62, 3823–3836.
58. Karine Villeneuve and William Tam*.
“Ruthenium-Catalyzed Isomerization of Oxa/azabicyclic Alkenes: an Expedient Route for the
Synthesis of 1,2-Naphthalene Oxides and Imines.”
J. Am. Chem. Soc. 2006, 128, 3514–3515.
57. Nicole Riddell and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions of Alkynyl Sulfides and Alkynyl Sulfones.”
J. Org. Chem. 2006, 71, 1934.
56. Karine Villeneuve and William Tam*.
“Ruthenium-Catalyzed Processes: Dual [2+2] Cycloaddition versus Cyclopropanation of
Bicyclic Alkenes with Propargylic alcohols.”
Organometallics 2006, 25, 843–848.
2005
55. William Tam*. (Invited Book Review)
“Ruthenium in Organic Synthesis.”
Angew. Chem. Int. Ed. 2005, 44, 6269–6270.
54. Woo-Jin Yoo, Anna Allen, Karine Villeneuve and William Tam*.
“Rhodium-Catalyzed Intramolecular [4+2] Cycloadditions of Alkynyl Halides.”
Org. Lett. 2005, 7, 5853–5856.
53. Nicole Riddell, Karine Villeneuve and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions of Ynamides.”
Org. Lett. 2005, 7, 3681–3684.
52. Woo-Jin Yoo, Gavin Tsui and William Tam*.
“Palladium-catalyzed Suzuki Coupling of 2,3-Dibromonorbornediene: Synthesis of 2,3-Diarylnorbornadienes.”
Eur. J. Org. Chem. 2005, 1044–1051.
2004
51. Karine Villeneuve, Nicole Riddell, Robert W. Jordan, Gavin Tsui and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions Between Bicyclic Alkenes and Alkynyl Halides.”
Org. Lett. 2004, 6, 4543–4546.
50. Robert W. Jordan, Peter R. Khoury, John D. Goddard* and William Tam*.
“Ruthenium-catalyzed [2+2] Cycloadditions Between 7-Substituted Norbornadienes and Alkynes: An Experimental and Theoretical Study.”
J. Org. Chem. 2004, 69, 8467–8474.
49. Alan J. Lough*, Karine Villeneuve and William Tam..
“5,6-[2α-Acetyl-1β-(ethoxycarbonyl)ethylidene]-1,3,3a,4,5,6,7,7a-octahydro-4,7-epoxy-isobenzofuran-1,3-dione.”
Acta Cryst. 2004, E60, o1659–o1660.
48. William Tam*. (Invited Mini Review)
“Recent Advances in Organometallic Chemistry Directed Towards Organic Synthesis.”
Chem. Int. 2004, 22–24.
47. Peter R. Khoury, John D. Goddard* and William. Tam.
“Ring Strain Energies: Substituted Rings, Norbornanes, Norbornenes and Norbornadienes.”
Tetrahedron 2004, 60, 8103–8112.
46. Alan J. Lough*, Karine Villeneuve and William Tam.
“(7S)-N-(4-Phenyltricyclo[4.2.1.02,5]non-3-ene-3-carbonyl)-2,10-camphorsultam.”
Acta Cryst. 2004, E60, o1566–o1567.
45. Karine Villeneuve and William Tam*.
“Asymmetric Induction in Ruthenium-Catalyzed [2+2] Cycloadditions Between Bicyclic Alkenes and Chiral Acetylenic Acylsultam.”
Angew. Chem. Int. Ed. 2004, 43, 610–613.
2003
44. Karine Villeneuve, Robert W. Jordan and William Tam*.
“Diastereoselective Ruthenium-Catalyzed [2+2] Cycloadditions between Bicyclic Alkenes and a Chiral Propargylic Alcohol and its Derivatives.”
Synlett 2003, 2123–2128.
43. Robert W. Jordan, William Tam and Alan J. Lough*.
“Ethyl 7-exo-acetoxy-4-phenyltricyclo[4.2.1.02,5]non-3-ene-3-carboxylate.”
Acta Cryst. 2003, E59, o1687–o1688.
42. William Tam, Alan J. Lough* and Robert W. Jordan.
“Ethyl 7-oxo-4-phenyltricyclo[4.2.1.02,5]non-3-ene-3-carboxylate.”
Acta Cryst. 2003, E59, o1685–o1686.
41. Alan J. Lough*, Robert W. Jordan and William Tam.
“Ethyl 4-Cyclohexyl-7-(dicyanomethylene)tricyclo[4.2.1.02,5]non-3-ene-3-carboxylate.”
Acta Cryst. 2003, E59, o1675–o1676.
40. Geoffrey K. Tranmer and William Tam*. (Invited Review)
“Bis(η2-ethene)(2,4-pentanedionato-O,O')rhodium.”
In "Encyclopedia of Reagents for Organic Synthesis [Online]", Editors: Paquette, L.; Rigby, J.; Wipf, P., John Wiley & Sons Ltd., article number RN00230, 2003, 6 pages.
39. Geoffrey K. Tranmer and William Tam*. (Invited Review)
“Bis(2-phenylindenyl)zirconium dichloride.”
In "Encyclopedia of Reagents for Organic Synthesis [Online]", Editors: Paquette, L.; Rigby, J.; Wipf, P., John Wiley & Sons Ltd., article number RN00229, 2003, 6 pages.
2002
38. Geoffrey K. Tranmer and William Tam*.
“Molybdenum-mediated Cleavage Reactions of Isoxazoline Rings Fused in Bicyclic Frameworks.”
Org. Lett. 2002, 4, 4101–4104.
37. William Tam*. (Invited Book Review)
“Topics in Current Chemistry 219. Cross-Coupling Reactions: A Practical Guide.”
J. Am. Chem. Soc. 2002, 124, 12630.
36. Peter D. Mayo and William Tam*.
“Ring-Opening Metathesis–Cross Metathesis Reactions (ROM–CM) of Substituted Norbornadienes and Norbornenes”
Tetrahedron 2002, 58, 9513–9525.
35. Peter D. Mayo and William Tam*.
“Palladium-Catalyzed Hydrophenylation of Bicyclic Alkenes.”
Tetrahedron 2002, 58, 9527–9540.
34. Peter D. Mayo and William Tam*. (Invited Review)
“Tris(acetoacetonyl)cobalt.”
In "Encyclopedia of Reagents for Organic Synthesis [Online]", Editors: Paquette, L.; Rigby, J.; Wipf, P., John Wiley & Sons Ltd., article number RN00084, 2002, 5 pages.
33. Geoffrey K. Tranmer and William Tam*.
“Palladium-Catalyzed Sonogashira Coupling of 2,3-Dibromonorbornadiene: Synthesis of Symmetrical and Unsymmetrical Norbornadiene-2,3-diynes.”
Synthesis 2002, 1675–1682.
32. Robert W. Jordan and William Tam*.
“Reactivity of the Alkene Component in the Ruthenium-Catalyzed [2+2] Cycloadditions between an Alkene and an Alkyne: Part 2.”
Tetrahedron Lett. 2002, 43, 6051–6054.
31. Marcel Schlaf*, Robert W. Jordan and William Tam.
“3-Ethoxy-7-methoxycarbonyl-4-phenyl-tricyclo[4.2.1.02,5]non-3-ene.”
Acta Cryst. 2002, E58, o629–o630.
2001
30. Robert W. Jordan and William Tam*.
“Study on the Reactivity of the Alkene Component in Ruthenium-Catalyzed [2+2] Cycloadditions between an Alkene and an Alkyne: Part 1.”
Org. Lett. 2001, 3, 2367–2370.
29. Peter Mayo, Galina Orlova, John D. Goddard* and William Tam*.
“Remote Substituent Effects on the Oxymercuration of 2-Substituted Norbornenes: An Experimental and Theoretical Study.”
J. Org. Chem. 2001, 66, 5182–5191.
28. Geoffrey K. Tranmer and William Tam*.
“Intramolecular 1,3-Dipolar Cycloadditions of Norbornadiene-Tethered Nitrones.”
J. Org. Chem. 2001, 66, 5113–5123.
27. Peter Mayo and William Tam*.
“Remote Substituted Effects on Regioselectivity in Pauson-Khand Reaction of 2-Substituted Norbornenes.”
Tetrahedron 2001, 57, 5943–5952.
26. Peter Mayo, Tiffany Hecnar and William Tam*.
“1,3-Dipolar Cycloaddition of Nitrile Oxides with Unsymmetrically Substituted Norborenenes.”
Tetrahedron 2001, 57, 5931–5941.
25. William Tam*, Geoffrey K. Tranmer and Alan J. Lough.
“6,9-Methano-4-methyl-3a,4,5a,6,9,10-hexahydro-5-oxa-1H,3H-furano[3,4-c]isoindol-3-one.”
Acta Cryst. 2001, E57, o269–o270.
24. Carol Yip, Sean Handerson, Geoffrey K. Tranmer, and William Tam*.
“Intramolecular 1,3-Dipolar Cycloadditions of Norbornadiene-Tethered Nitrile Oxides.”
J. Org. Chem. 2001, 66, 276–286.
2000
23. Robert W. Jordan and William Tam*.
“Ruthenium-Catalyzed [2+2] Cycloadditions of 2-Substituted Norbornenes.”
Org. Lett. 2000, 2, 3031–3034.
22. Geoffrey K. Tranmer, Peter Keech, and William Tam*.
“Intramolecular 1,3-Dipolar Cycloadditions of 2-Substituted Norbornadiene-Tethered Nitrones.”
Chem. Commun. 2000, 863–864.
21. Geoffrey K. Tranmer, Carol Yip, Sean Handerson, Robert W. Jordan, and William Tam*.
“Synthesis of 2,3-disubstituted norbornadienes.”
Can. J. Chem. 2000, 78, 527–535.
20. William Tam*, Sean Handerson, and George Ferguson.
“2,3,3a,4,5a,6,7,8-Octahydro-5a-methyl-6,9-methano-1H,9H-5-oxa-4-azacyclopenta[c]indene.”
Acta Cryst. 2000, C56, e71.
1999
19. Peter Mayo, Marc Poirier, Jan Rainey, and William Tam*.
“Effect of a Remote Substituent on Regioselectivity in Oxymercuration of Unsymmetrical Substituted Norbornenes.”
Tetrahedron Lett. 1999, 40, 7727–7730.
18. Carol Yip, Sean Handerson, Robert Jordan, and William Tam*.
“Highly Regio- and Stereoselective Intramolecular 1,3-Dipolar Cycloadditions of Norbornadiene-Tethered Nitrile Oxides.”
Org. Lett. 1999, 1, 791–794.
1998
17. Mark Lautens* and William Tam. (Book Chapter)
“Transition Metal-Catalyzed Cycloadditions with Bicyclo[2.2.1]hepta-2,5-dienes.”
in "Advances in Metal-Organic Chemistry", Vol. 6, Chapter 2, pp. 49-101, Editor: Lanny S. Liebeskind, JAI Press, 1998.
16. Mark Lautens* and William Tam. (Book Chapter)
“Transition Metal-Catalyzed Enantioselective and Stereoselective Cycloaddition Reactions.”
in “Organometallic Reagents in Organic Synthesis”, Editor: Bateson, J.H. and Mitchell, M.B., Academic Press: London, 1998, p. 273.
1997
15. Anthony G.M. Barrett* and William Tam.
“Regioselective Ring Opening of Vinylcyclopropanes by Hydrogenation with Palladium on Activated Carbon.”
J. Org. Chem, 1997, 62, 7673–7678.
14. Anthony G.M. Barrett* and William Tam.
“Studies on Mercury(II)-Mediated Opening of Bi- and Tercyclo-propane Arrays.”
J. Org. Chem. 1997, 62, 4653–4664.
13. Mark Lautens*, William Tam, and James Blackwell.
“Synthesis of Highly functionalized Diquinanes by the Regio- and Stereoselective Cleavage of Homo-Diels-Alder Cycloadducts.”
J. Am. Chem. Soc. 1997, 119, 623–624.
1996
12. Mark Lautens*, Wolfgang Klute and William Tam.
“Transition Metal-Mediated Cycloaddition Reactions.”
Chem. Rev. 1996, 96, 49–92.
1995
11. Mark Lautens*, Alan J. Lough and William Tam.
“An Unusual trans-Fused Cyclopentane Ring System at 158 K.”
Acta Cryst. 1995, C51, 1944–1946.
10. Mark Lautens*, Alan J. Lough and William Tam.
“4-[(Trimethylsilyl)methyl]tetracyclo[5.4.0.06,10.09,11]undecan-3-yl-3,5-Dinitrobenzoate.”
Acta Cryst. 1995, C51, 471–473.
9. Mark Lautens*, Louise G. Edwards, William Tam, and Alan J. Lough.
“Nickel-Catalyzed [2+2+2] (Homo Diels-Alder) and [2+2] Cycloadditions of Bicyclo[2.2.1]hepta 2,5-dienes.”
J. Am. Chem. Soc. 1995, 117, 10276–10291.
8. Mark Lautens*, William Tam, Julia Craig Lautens, Louise G. Edwards, Cathleen M. Crudden and A. Catherine Smith.
“Cobalt-Catalyzed [2+2+2] (Homo Diels-Alder) and [2+2+4] Cycloadditions of Bicyclo[2.2.1]hepta-2,5-dienes.”
J. Am. Chem. Soc. 1995, 117, 6863–6879.
1994
7. Mark Lautens*, William Tam and Louise G. Edwards.
“Stereoselectivity in the Homo-Diels-Alder Reaction: Effect of Remote 7-Substituent on Nickel Catalyzed Cycloadditions.”
J. Chem. Soc., Perkin Trans 1. 1994, 2143–2150.
1993
6. Mark Lautens*, William Tam and Christian Sood.
“Enantioselective Cobalt-Catalyzed [4+2+2] Cycloadditions.”
J. Org. Chem. 1993, 58, 4513–4515.
1992
5. Mark Lautens*, William Tam and Louise G. Edwards.
“Cobalt-Catalyzed Intramolecular Homo Diels-Alder Reactions.”
J. Org. Chem. 1992, 57, 8–9.
1990
4. William Tam. (Book)
“Worked Examples in Inorganic Chemistry: A study guide for the preparation of the Hong Kong Advanced Level and the GCE (London and Cambridge Board) A-Level Examinations.”
Lantco Publisher: Hong Kong, 1990, 153 pages.
1989
3. William Tam. (Book)
“Worked Examples in Physical Chemistry: A study guide for the preparation of the Hong Kong Advanced Level and the GCE (London and Cambridge Board) A-Level Examinations.”
Lantco Publisher: Hong Kong, 1989, 311 pages.
1988
2. William Tam. (Book)
“Suggested Solutions for the Hong Kong Advanced Level Examinations in Chemistry for the Past Ten Years: A study guide for the preparation of the Hong Kong Advanced Level and the GCE (London and Cambridge Board) A-Level Examinations.”
Lantco Publisher: Hong Kong, 1988, 588 pages.
1. William Tam. (Book)
“Worked Examples in Organic Chemistry: A study guide for the preparation of the Hong Kong Advanced Level and the GCE (London and Cambridge Board) A-Level Examinations.”
Lantco Publisher: Hong Kong, 1988, 283 pages.
Awards
2021: CEPS Excellence in Undergraduate Teaching Award
2006 - 2008: University of Guelph Presidential Distinguished Professor Award (for Teaching and Research)
2007: University of Guelph Faculty Association Distinguished Professor Award (Teaching Award)
2007 - 2013: One of the Top 1% most cited chemists worldwide (Essential Science Indicators)
2000: Elected by the international journal SYNLETT as one of the 25 most outstanding starting Assistant Professors worldwide
2000: Boehringer Ingelheim Young Investigator Award for Organic Chemistry
1999: Ichikizaki Fund for Young Chemists
1996 - 1998: NSERC Postdoctoral Fellowship