Dr. Jennifer Geddes-McAlister

My keen interest in scientific research and academics began during my undergraduate degree at the University of Lethbridge, where I investigated the impact of fungal pathogens on agricultural development and performed my first proteomics experiments. This amazing experience led to a PhD in the laboratory of Dr. Jim Kronstad at UBC, where I applied quantitative proteomics to comprehensively profile the cellular proteome and secretome of the fungal pathogen, Cryptococcus neoformans. My fascination with mass spectrometry-based proteomics and pathogenesis provided the foundation for a postdoctoral fellowship supported by NSERC and the Alexander von Humboldt Foundation in the laboratory of Prof. Dr. Matthias Mann at the Max Planck Institute of Biochemistry in Munich, Germany. During my postdoc, I combined my expertise in microbiology and proteomics with experimental systems immunology to profile the interplay between Salmonella and its host during infection. At the University of Guelph, my research group will blend cutting-edge proteomics technologies with a systems biology perspective to explore host-pathogen interactions.

• BSc (co-op) – University of Lethbridge, Biological Sciences
• MSc – University of Lethbridge, Biological Sciences
• PhD – University of British Columbia, Microbiology and Immunology
• Postdoctoral Fellow – Max Planck Institute of Biochemistry, Proteomics and Signal Transduction

We are interested in characterizing the mechanisms of pathogenesis, adaptation, and survival in fungal and bacterial microbes from a systems biology perspective through mass spectrometry-based quantitative proteomics. Specifically, research in the lab centres around the following areas:

1. Differential patterns of pathogenic regulation between microbial species;
2. Systems biology to elucidate microbial proteome dynamics and interactions;
3. Mechanistic characterization of pathogenic proteins; and
4. Mass spectrometry-based proteomics for drug discovery and repurposing.

Our long-term goals emphasize the utilization of mass spectrometry-based proteomics to fundamentally understand differential microbial adaptation and survival strategies and to integrate a novel systems biology platform for investigation of diverse biological systems, defining functional mechanisms of cellular regulation and pathogenesis.

Interested students and post-doctoral fellows are encouraged to contact me to learn more about new and exciting opportunities.

Google Scholar

(*denotes corresponding authorship)

2025

• Romero O., Galarneau, M., Cox, S., Geddes-McAlister, J.* (In Review) Aspergillus fumigatus isolated from diverse wildfowl exhibit distinct antifungal susceptibility profiles driven by genetic and non-genetic determinants.
• Ball, B., Chan, N., West, H., Sukumaran, A., Carruthers-Lay, D., Woods, M., Geddes-McAlister, J.* (In Revision) New antifungal targets, immunization candidates, and pan-fungal protection revealed through the cryptococcal infectome.
• Mainprize, I., Roach, E., Geddes-McAlister, J., Khursigara, C.M., Wills, M. (In Revision) The proteomic response of Borrelia burgdorferi exposed to doxycycline. Proteomics.
• Geddes-McAlister, J.*, Sukumaran, A., Vogt, S.L., Rowland, J.L., Woodward, S.E., Muselius, B., Gee, L., Roach, E.J., Khursigara, C.M., Raupach, B., Finlay, B.B., Meissner, F. (In Revision). Dual perspective proteomics infectome profiling discovers Salmonella type III secretion system effector functions in macrophages. PLOS Pathogens.
• Zhu, X., Morency, C., Picard, M-E., Mosterd, C., McAlister, J., Perrault-Jolicoeur, A., Geddes-McAlister, J., Shi, R., Moineau, S. (In Revision) HEPN-AbiV is an RNase in the antiphage system AbiV. Nucleic Acid Res.
• Ball, B., Chan, N., West, H., Sukumaran, A., Carruthers-Lay, D., Woods, M., Geddes-McAlister, J.* (In Revision). Integrated dual perspective infectome profiling and phenome fingerprinting reveal new antifungal targets, fungal immunization candidates, and pan-fungal protection. Nature Communications.
• Woods, M., Bermas, A., Ball, B., Muselius, B., Chan, N., Gutierrez-Gongora, D., McAlister, J.A., Sieber, S.A., Geddes-McAlister, J.* (In Revision) Reversing fluconazole resistance through disruption of ClpX. Nature Communications.
• Geddes-McAlister, J.*, Uhrig, R.G. (In Review) The plant proteome delivers from discovery to innovation. Trends in Plant Science (Invited submission).
• Sun, J., McAlister J.A., Geddes-McAlister, J.* (In Review) Temporal and thermal optimization of trypsin digestion for the cryptococcal proteome. Microbiology Resource Announcements.
• Rizakos, T., Geddes-McAlister, J.* (In Revision) Altered proteome of a Cystic fibrosis cell line model upon exposure to Pseudomonas aeruginosa biofilms. Microbiology Resource Announcements.
• Rizakos, T., Geddes-McAlister, J.* (In Review) Remodeling of the neutrophil proteome upon exposure to Pseudomonas aeruginosa biofilms. Microbiology Resource Announcements.
• Kheradvar, K., Prudhomme, N., McLean, M.D., Cossar, D., Geddes-McAlister, J.* (In Revision) Assessment of bacterial proteome remodeling under virulence-inducing conditions for molecular pharming applications. Microbiology Resource Announcements.
• Zhu W.Y., Segeren L., Chan, N., Ball, B., Geddes-McAlister, J.* (In Revision) Proteome remodeling upon disruption of virulence-associated CipC from Cryptococcus neoformans. Microbiology Resource Announcements.
• Reitzel, C., Geddes-McAlister, J.* (In Revision) Lon protease-mediated secretome profiling in Klebsiella pneumoniae. Microbiology Resource Announcements.
• Olabisi-Adeniyi, E., McAlister, J.A., Ferretti, D., Cox, J., Geddes-McAlister, J.* (In Revision) ProteoPlotter: an executable proteomics visualization tool compatible with Perseus. J Proteome Research.
• Sa, M., da Silva, M., Ball, B., Geddes-McAlister, J.* (In Revision) Revealing the dynamics of fungal disease with proteomics. Molecular OMICs. Invited submission.

2024

• Ball, B., Sukumaran, A., Krieger, J.R., Geddes-McAlister, J.* (2024) Comparative DDA- and DIA-PASEF proteomics profiling of cross-kingdom macrophage infection reveals new mechanisms driving pathogen virulence. J. Proteome Research.
• Shaftoe, J.B., Geddes-McAlister, J., Gillis, T.E. (2024) Integrated cellular response to zebrafish (Danio rerio) heart to temperature change. J. Exp. Biol.
• Grafinger, O.R., Hayward, J., Meng, Y., Geddes-McAlister, J., Mar, S., Sheng, M., Su, B., Thillainadesan, G., Lipsman, N., Trant, J.F., Coppolino, M.G., Jerzak, K.J., Leong, H.S. (2024) Cancer Cell Extravasation Requires ⁱPlectin Mediated Choreography of MT1-MMP at Invadopodia. British Journal of Cancer.
• Geddes-McAlister, J.*, Droit, A. (2024) Formation of the Canadian Artificial Intelligence and Mass Spectrometry for Systems Biology (CAN-AIMS) Consortium. Exp. Rev. Proteomics. Invited submission.
• Ball, B., Sukumaran, A., Pladwig, A., Kazi, S., Chan, N., Modrakova, M., Geddes-McAlister, J.* (2024). Proteome signatures reveal homeostatic and adaptive oxidative responses by a putative co-chaperon, Wos2, to influence fungal virulence determinants in cryptococcosis. Microbiol Spectrum. 0, e00152-24.
• Prudhomme, N., Pastora, R., Zhang, E., Sproule, A., Krieger, J.R., Murphy, J.P., Overy, D., Cossar, D., McLean, M.D., Geddes-McAlister, J.* (2024). Bacterial growth-mediated systems remodeling of Nicotiana benthamiana defines unique signatures modulating target production in molecular pharming. Plant Biotechnology Journal. 22: 2248 – 2266.
• Gutierrez-Gongora, D., Woods, M, Prosser, R.S., Geddes-McAlister, J.* (2024). Natural compounds from freshwater mussels disrupt virulence determinants and influence fluconazole susceptibility in the presence of macrophages for Cryptococcus neoformans. Microbiology Spectrum. 12, e02841-23.
• Geddes-McAlister, J.*, Hansmeier, N. (2024) Canadian Proteomics: A Journey Across the Country Highlights Discovery and Innovation. J Proteome Research. 23: 5229-5232. Invited submission.
• Geddes-McAlister, J.*, Roux-Dalvai, F., Droit, A. (2024). Proteomics, Bioinformatics, and Infectious Diseases. Genetics and Evolution of Infectious Diseases (Book; Wiley Publishers). 465 – 492. Invited submission.
• Geddes-McAlister, J.*, Hansmeier, N., (2024). Quantitative Proteomics of the Intracellular Bacterial Pathogen Salmonella enterica serovar Typhimurium. Methods in Molecular Biology: Intracellular Pathogens. 2813: 107-115. Invited Submission.
• Muselius, B., Geddes-McAlister, J.* (2024) In vivo modeling of Cryptococcus neoformans infection and collection of tissue samples. Methods in Molecular Biology: Cryptococcus neoformans. 2775: 47-55. Invited Submission.
• Muselius, B., Roux-Dalvai, F., Droit, A., Geddes-McAlister, J.* (2024) Proteomic profiling of tissue samples collected from Cryptococcus neoformans murine model of infection. Methods in Molecular Biology: Cryptococcus neoformans. 2775: 127-137. Invited Submission.
• Rizakos, T., & Geddes-McAlister, J.* (2024) A STAGE tip procedure for desalting and purification of peptides. J Visual Experiments. (Invited submission)
• Rizakos, T., & Geddes-McAlister, J.* (2024) The isolation and digestion of proteins from neutrophils. J Visual Experiments. (Invited submission)

2023

• Agustinho, D.P., Brown, H., Chen, G., Gaylord, E.A., Geddes-McAlister, J., Brent, M.R., Doering, T.L. (2023) Unbiased discovery of natural sequence variants that influence fungal virulence. Cell Host & Microbe.
• Goodyear, M.C., Seidel, L., Krieger, J.R., Geddes-McAlister, J., Levesque, R.C., Khursigara, C.M. (2023) Quantitative proteomics reveals unique responses to antimicrobial treatments in clinical Pseudomonas aeruginosa isolates. mSystems
• Torabi, S., Seifi, S., Geddes-McAlister, J., Tenuta, A., Wally, O., Torkamaneh, D., Eskandari, M. (2023). Soybean-SCN duel: Novel insight into Soybean’s Resistant Responses to Heterodera glycines. Int J Mol Sci.
• Geddes-McAlister, J.*, Rizakos, T., Muselius, B. (2023) Mass spectrometry-based proteomics of eukaryotes. Detection and Analysis of Microorganisms by Mass Spectrometry (Book; Royal Society of Chemistry). Invited submission.
• Muselius, B., Roux-Dalvai, F., Droit, A., Geddes-McAlister, J.* (2023) Resolving the temporal splenic proteome during fungal infection for discovery of putative dual perspective biomarker signatures. J American Society of Mass Spectrometry. Invited submission (Focus: Emerging scholars)
• Reitzel, C., Sukumaran, A., O’Connor, S., Muselius, B., Geddes-McAlister, J.* (2023) Profiling of the Klebsiella pneumoniaephosphoproteome under iron-limited and iron-replete conditions. Microbiology Resource Announcement (Proteomics)
• Reitzel, C., Sukumaran, A., Zanetti, C., Muselius, B., Geddes-McAlister, J.* (2023) Phosphoproteome profiling of Klebsiella pneumoniae under zinc-limited and zinc-replete conditions. Microbiology Resource Announcement (Proteomics)
• Liu, B., Johal, D., Buchanan, R., Ball, B., Serajazari, M., Geddes-McAlister, J.* (2023) Quantitative phosphoproteome analysis of a cereal crop fungal pathogen’s interaction with the host. Methods Mol Biol: Plant-Pathogen Interactions (Invited submission; Book Chapter).
• Buchanan, R., Serajazari, M., Geddes-McAlister, J.* (2023) Proteomic profiling of host response in the cereal crop Triticum aestivum to the mycotoxin, 15-acetyldeoxynivalenol, produced by the fungal pathogen, Fusarium graminearum. Methods Mol Biol: Plant-Pathogen Interactions (Invited submission; Book Chapter)
• Petenkova, A., Lu, X., Quellier, D., Carter, D., To, O.T., Lamb, J., Kugadas, A., Geddes-McAlister, J., Sykes, D.B., Auger, S., Fichorova, R., Distefano, M., Gadjeva, M. (2023). Prenylcysteine oxidase 1-like protein is required for neutrophil bactericidal properties. Nature Communications.
• Woods, M., McAlister, J.A., Geddes-McAlister, J.* (2023) A One Health approach to overcoming antifungal resistance. WIREs: Mechanisms of Disease (invited submission)
• Gutierrez-Gongora, D., Raouf-Alkadhimi, F., Prosser, R.S., Geddes-McAlister, J.* (2023) Differentiated protein extracts from freshwater and terrestrial mollusks inhibits virulence factor production in Cryptococcus neoformans. Scientific Reports.
• Santiago-Tirado, F.H., Hurtaux, T., Geddes-McAlister, J., Nguyen, D., Helms, V., Doering, T.L., Römisch, K. (2023). The ER protein translocation channel subunit Sbh1 controls virulence of Cryptococcus neoformans. MBio.
• Ince, L.M., Barnoud, C., Lutes, L., Pick, R., Wang, C., Sinturel, F., Chen, C.S., de Juan, A., Weber, J., Holtkamp, S.J., Geddes-McAlister, J., Hergenhan, S.M., Ebner, S., Fontannaz, P., Meyer, B., Vono, M., Jemelin, S., Dibner, C., Siegrist, C.A., Meissner, F., Graw, F., Scheiermann, C. (2023) Benefit of circadian clocks in adaptive immunity and vaccination responses. Nature Communications.

2022

• Geddes-McAlister, J.* (2022). ‘Moms in Proteomics’ pushes for change. Nature. (Invited submission)
• Geddes-McAlister, J.* & Schriemer, D.C. (2022) 13^th Annual Symposium of the Canadian National Proteomics Network. Expert Reviews of Proteomics. (Invited submission)
• Gutierrez-Gongora, D., Raouf-Alkadhimi, F., Prosser, R.S., Geddes-McAlister, J.* (2022). Assessing the putative anticryptococcal properties of crude and clarified extracts from mollusks. Journal of Visualized Experiments. (Invited submission).
• Teelucksingh, T., Thompson, L., Gilbert, S., MacNair, C., Kuehfuss, N., Goetz, J., Geddes-McAlister, J., Brown, E., Cox, G. (2022) A genetic platform to investigate bacterial drug efflux pumps. Nature Chem Biol
• Sukumaran, A.¹, Ball, B.¹, Krieger, J.R., Geddes-McAlister, J.* (2022). Cross-kingdom infection of macrophages reveals pathogen- and immune-specific global reprogramming and adaptation. MBio. ¹Authors contributed equally.
• Geddes-McAlister, J.* (2022) ‘Moms in Proteomics’ aims to bring together a community for supporting moms in STEM. The Conversation. (Invited submission)
• Geddes-McAlister, J.* (2022) Moms in Proteomics: Building a Supportive and Unified Community. Trends in Biochemical Sciences (Invited Submission)
• Geddes-McAlister, J.* (2022) Systems biology in fungal research. J of Fungi. (Invited submission)
• Geddes-McAlister, J.*, McLean, M.D., Cossar, D., Prudhomme, N., Gutierrez-Gongora, D. (2022) Emerging role of mass spectrometry-based proteomics in molecular pharming. Curr Opin Chem Biol. (Invited Submission)
• Gutierrez-Gongora, D., Geddes-McAlister, J.* (2022). Peptidases: promising antifungal targets of the human fungal pathogen, Cryptococcus neoformans. FACETS. (Invited submission)
• Meissner, F., Geddes-McAlister, J., Mann, M., Bantscheff, M. (2022) The emerging role of mass spectrometry-based proteomics in drug discovery. Nature Reviews Drug Discovery. (Invited submission)
• Geddes-McAlister, J.* (2022) Proteomics in Systems Biology. Methods in Molecular Biology (Book; Invited Editor)
• Ball, B., Krieger, J., Geddes-McAlister, J.* (2022) Phosphoproteomic sample preparation for global phosphorylation profiling of a fungal pathogen. Methods Mol Biol: Proteomics in Systems Biology (Invited submission; Book Chapter)
• Liu, B., Johal, D., Ball, B., Serajazari, M., Geddes-McAlister, J.* (2022) Label-free quantitative proteomic profiling of Fusarium head blight in wheat. Methods Mol Biol: Proteomics in Systems Biology (Invited submission; Book Chapter)
• Prudhomme, N., Krieger, J.R., McLean, M., Cossar, D., Geddes-McAlister, J.* (2022) Proteomic profiling of interplay between Agrobacterium tumefaciens and Nicotiana benthamiana for improved molecular pharming outcomes. Methods Mol Biol: Proteomics in Systems Biology (Invited submission; Book Chapter)
• Sukumaran, A., Geddes-McAlister, J.* (2022) Proteomic profiling of the interplay between a bacterial pathogen and host uncovers novel anti-virulence strategies. Methods Mol Biol: Proteomics in Systems Biology (Invited submission; Book Chapter)

2021

• Liu, B., Stevens-Green, R., Johal, D., Buchanan, R., Geddes-McAlister, J.* (2021). Fungal pathogens of cereal crops: Proteomic insights into fungal pathogenesis, host defense, and resistance. J Plant Physiology. (Invited submission)
• Ball, B., Woroszchuk, E., Sukumaran, A., West, H., Afaq, A., Carruthers-Lay, D., Muselius, B., Gee, L., Langille, M., Pladwig, S., Kazi, S., Hendriks, A., Geddes-McAlister, J.* (2021) Proteomic profiling of zinc limitation in Cryptococcus neoformans reveals regulation of vesicle-associated factors. BMC Microbiology.
• Gutierrez-Gongora, D., Geddes-McAlister, J.* (2021). From naturally-sourced protease inhibitors to new treatments for fungal infections. J of Fungi. (Invited submission)
• Muselius, B., Durand, S.L., Geddes-McAlister, J.* (2021) Proteomics of Cryptococcus neoformans: From the lab to the clinic. Int J Molecular Sciences. (Invited submission)
• Goodyear, M.C., Garnier, N., Krieger, J.R., Geddes-McAlister, J.*, Khursigara, C.M.* (2021) Label-free quantitative proteomics identifies unique proteomes of clinical isolates of the Liverpool Epidemic Strain of Pseudomonas aeruginosa and laboratory strain PAO1. Proteomics Clinical Applications.
• Grafinger, O.R., Stirling, T., Geddes-McAlister, J., Coppolino, M.G. (2021) Inhibition of b1 integrin induces its association with MT1-MMP and decreases MT1-MMP internalization and cellular invasiveness. Cellular Signalling.
• Sukumaran, A., Pladwig, S., Geddes-McAlister, J.* (2021) Zinc limitation in Klebsiella pneumoniae profiled by quantitative proteomics influences transcriptional regulation and cation transporter-associated capsule production. BMC Microbiol.
• Retanal, C., Ball, B. & Geddes-McAlister, J.* (2021) Post-translational modifications drive success and failure of fungal-host interactions. J of Fungi (Invited submission)
• Rosiana, S., Zhang, L., Kim, GH., Retovich, AV., Sukumaran, A., Geddes-McAlister, J., Kirienko, NV., Shapiro, RS. (2021) Systematic characterization and genetic interaction analysis of adhesins in Candida albicans virulence. Genetics.
• Prudhomme, N., Gianetto-Hill, C., Pastora, R., Cheung, W.-F., Allen-Vercoe, E., McLean, M.D., Cossar, D., Geddes-McAlister, J.* (2021) Quantitative proteomic profiling of shake flask versus bioreactor growth reveals distinct responses of Agrobacterium tumefaciens for preparation in molecular pharming. Can. J. Microbiol.
• Prudhomme, N., Pastora, R., Muselius, B., McLean, M.D., Cossar, D., Geddes-McAlister, J.* (2021) Exposure of Agrobacterium tumefaciens to agroinfiltration medium demonstrates cellular remodeling and may promote enhanced adaptability for molecular pharming. Can. J. Microbiol.

2020

• Tremblay, O., Thow, Z., Geddes-McAlister, J., A. Rod Merrill. (2020) Several New Putative Bacterial ADP-Ribosyltransferase Toxins Are Revealed from In Silico Data Mining, Including the Novel Toxin Vorin, Encoded by the Fire Blight Pathogen Erwinia amylovora. Toxins.
• Geddes-McAlister, J.*, Sukumaran, A., Patchett, A., Hager, H.A., Dale, J.C.M., Roloson, J.L., Prudhomme, N., Bolton, K., Muselius, B., Powers, J., Newman, J.A. (2020) Examining the impacts of CO₂ concentration and genetic incompatibility on perennial ryegrass-Epichloee festucae var lolii interactions. J of Fungi.
• Van Gelder, K., Virta, L., Easlick, J., Prudhomme, N., McAlister, J., Geddes-McAlister, J., Akhtar, T. (2020) A central role for polyprenol reductase in plant dolichol biosynthesis. Plant Sci.
• Sukumaran, A., Woroszchuk, E., Ross, T., Geddes-McAlister, J.* (2020) Proteomics of host-bacterial interactions: new insights from dual perspectives. Can. J. Microbiol. (Invited submission).
• Ball, B., Sukumaran, A., Geddes-McAlister, J.* (2020) Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions. J Visual Experiments. (Invited submission).
• Ball, B., Langille, M., Geddes-McAlister, J.* (2020) Fun(gi)OMICS: advanced and diverse technologies to explore emerging fungal pathogens. MBio. (Invited submission)
• Bermas, A. and Geddes-McAlister, J.* (2020) Experimental evolution of antifungal resistance in Cryptococcus neoformans. Curr Prot Microbiol. (Invited submission)
• Yeung, J., Lamb, J., Krieger, J., Gadjeva, M., Geddes-McAlister, J.* (2020) Quantitative proteomic profiling of murine ocular tissue and the extracellular environment. Curr Prot Mouse Biol. (Invited submission, cover image)
• Geddes-McAlister, J.* (2020) Pathogenesis of Fungal and Bacterial Microbes. Pathogens. (Editorial; Invited submission)
• Horianopoulos, L., Gluck-Thaler, L., Benoit Gelber, I., Cowen, L., Geddes-McAlister, J., Landry, C., Schwartz, I., Scott, J., Sellam, A., Sheppard, D., Spribille, T., Subramaniam, R., Walker, A., Harris, S., Shapiro, R., Gerstein, A. (2020) The Canadian Fungal Research Network: current challenges and future opportunities. Can. J. Microbiol.
• Bermas, A., Geddes-McAlister, J.* (2020) Combatting the evolution of antifungal resistance in Cryptococcus neoformans. Mol Micro. (Invited submission)
• Muselius, B.¹, Sukumaran, A.¹, Yeung, J., Geddes-McAlister, J.* (2020) Iron limitation in Klebsiella pneumoniae defines new roles for Lon protease in homeostasis and degradation by quantitative proteomics. Front Microbiol. ¹Authors contributed equally.
• Anderson, E.M., Sychantha, D., Brewer, D., Clarke, A.J., Geddes-McAlister, J.*, Khursigara, C.M.* (2020) Peptidoglycomics: Examining compositional changes in peptidoglycan between biofilm- and planktonic-derived Pseudomonas aeruginosa. J Biol Chem.
• Yeung, J., Gadjeva, M., Geddes-McAlister, J.* (2020) Label-free quantitative proteomics distinguishes general -and site-specific host responses to Pseudomonas aeruginosa infection at the ocular surface. Proteomics.

2019

• Geddes-McAlister, J., Kugadas, A., Gadjeva, M. (2019) Tasked with a challenging objective: why do neutrophils fail to battle Pseudomonas aeruginosa biofilms? Pathogens. (Invited submission)
• Ball, B., Geddes-McAlister, J.* (2019) Quantitative proteomic profiling of Cryptococcus neoformans. Curr Protoc Microbiol. (Invited submission & cover image)
• Sukumaran, A., Coish, J., Yeung, J., Muselius, B., Gadjeva, M., MacNeil, A.J., Geddes-McAlister, J.* (2019). Decoding communication patterns of the innate immune system by quantitative proteomics. J Leukocyte Biol.
• Geddes-McAlister, J.*, Gadjeva, M. (2019). Mass spectrometry-based quantitative proteomics of murine-derived polymorphonuclear neutrophils. Current Protocols in Immunology.
• Ball, B., Bermas, A., Carruthers-Lay, D., Geddes-McAlister, J.* (2019) Mass Spectrometry-Based Proteomics of Fungal Pathogenesis, Host–Fungal Interactions, and Antifungal Development. J Fungi.
• Rea, K.A., Casaretoo, J.A., Al-Abdul-Wahid, M.S., Sukumaran, A., Geddes-McAlister, J., Rothstein, S.J., Akhtar, T.A. (2019). Biosynthesis of cannflavins A and B from Cannabis sativa L. Phytochemistry.
• Kugadas A., Geddes-McAlister, J., Guy, E., DiGiandomenico, A., Sykes, D.B., Mansour, M.K., Mirchev, R., Gadjeva, M. (2019). Employing enzymatic treatment options for management of ocular biofilm-based infections. J Leukocyte Biol.

2017 & 2018

• Geddes-McAlister, J., Shapiro, R.S. (2018) New pathogens, new tricks: emerging, drug-resistant fungal pathogens and future prospects for antifungal therapeutics. Antimicrobial Therapeutics Reviews, Annals of the New York Academy of Sciences.
• Kugadas A., Wright Q., Geddes-McAlister, J., Gadjeva, M. (2017) Role of microbiota in strengthening ocular mucosal barrier function through secretory IgA. Investigative Ophthalmology & Visual Science.

2015 & 2016

• Geddes, J.M.H., Caza, M., Croll, D., Stoynov, N., Foster, L.J., Kronstad, J.W. (2016) The ubiquitin-proteasome pathway in Cryptococcus neoformans influences capsule production, is regulated by protein kinase A, and is an antifungal target. MBio.
• Geddes, J.M.H., Croll, D., Caza, M., Stoynov, N., Foster, L.J., Kronstad, J.W. (2015) Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by Protein Kinase A. BMC Microbiol.

2012 & earlier

• Kronstad, J.W., Saikia, S., Nielson, E.D., Kretschmer, M., Jung, W., Hu, G., Geddes, J.M.H., Griffiths, E.J., Choi, J., Cadieux, B., Caza, M., Attarian, R. (2012) Adaptation of Cryptococcus neoformans to mammalian hosts: integrated regulation of metabolism and virulence. Eukaryotic Cell.
• Kronstad, J.W., Attarian, R., Cadieux, B., Choi, J., D’Souza, C.A., Geddes, J.M.H., Griffiths, E.J., Hu, G., Jung, W., Kretschmer, M., Saikia, S., Wang, J. (2011) Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box. Nature Reviews Microbiology.
• Geddes, J.M.H., Eudes, F., Laroche, A., Selinger, L. B. (2008) Differential expression of proteins in response to the interaction between the pathogen Fusarium graminearum and its host, Hordeum vulgare. Proteomics.
• Geddes, J.M.H., Eudes, F., Tucker, J. R., Legge, W. G., Selinger, L.B. (2008) Evaluation of inoculation methods on Fusarium graminearum infection and deoxynivalenol production in barley. Canadian Journal of Plant Pathology.

Links and Media

Canadian National Proteomics Network

https://cnpn.ca

Canadian National Proteomics Network – Unity Initiative

https://cnpn.ca/unity/

Moms in Proteomics

https://momsinproteomics.ca

In the news:

University of Guelph News

CTV Kitchener

CBC Radio – Fresh Air

C

Canadian Artificial Intelligence and Mass Spectrometry for Systems Biology (CAN-AIMS) Consortium

https://canaims.ca

Ontario Early Researcher Award

https://news.uoguelph.ca/2022/05/five-u-of-g-faculty-recognized-with-early-researcherawards/

https://www.uoguelph.ca/mcb/news/2022/05/congratulations-dr-geddes-mcalister-and-dr-zhang-being-recognized-early-researcher

Industry Partnerships

https://uoguelphca.sharepoint.com/sites/OVCResearch/SitePages/Industry-Partnerships-Week.aspx

https://www.uoguelph.ca/mcb/news/2021/06/how-improve-drug-production-unbe-leaf-able-story

https://api.liveugconthub.uoguelph.dev/sites/default/files/migration/ug_profile/files/inline_files/RIO_AnnualReport_2019-2021FINAL.pdf

https://www.uoguelph.ca/cbs/news/2020/04/“studying-proteins-necessary-understand-interactions-world”-how-proteomics-can-help

Banting Research Foundation

https://www.bantingresearchfoundation.ca/wp-content/uploads/2022/03/FY21_AR_v07.pdf

https://www.bantingresearchfoundation.ca/xt_volanteers/jennifer-geddes-mcalister-phd-2/

Research highlights

https://www.uoguelph.ca/cbs/news/2020/11/two-u-g-cbs-faculty-awarded-srcf-research-grants

https://researchoutreach.org/articles/proteomics-reveals-new-possibilities-fight-against-infection/

https://news.uoguelph.ca/2020/05/three-u-of-g-research-projects-receive-federal-funding/

https://news.uoguelph.ca/2020/05/u-of-g-awards-funding-for-covid-19-research-projects/

https://www.wellingtonadvertiser.com/1-million-in-grants-for-u-of-g-research-through-canada-foundation-for-innovation/

https://www.guelphmercury.com/news-story/9545970-feds-give-1m-to-u-of-guelph-for-research-projects/

https://www.guelphtoday.com/local-news/u-of-g-receives-1m-from-feds-to-study-effects-of-microplastics-on-ecosystem-3825600

https://news.uoguelph.ca/2019/08/cfi-invests-1m-in-u-of-g-research/

Current trainees

Post-doctoral fellows

• Mariana Sa, PhD, 2023 – present (NSERC CREATE EvoFunPath Fellow 2024 – 2025)

Graduate students

• Matthew Rennie, MSc student, 2024 – present
• Jacob Hambly, MSc Bioinformatics student, 2024 – present
• Oscar Romero Gonzalez, PhD Student, 2024 – present
• Mayara Barbara Da Silva, PhD Student, 2023 – present (NSERC CREATE EvoFunPath Fellow 2024 – 2025)
• Jiaxi Lu, PhD Student, 2023 – present (NSERC CREATE EvoFunPath Fellow 2024 – 2025)
• Sujani Rathnayake, PhD Candidate, 2023 – present (Brock Scholarship 2023 – 2027; Vanier Scholarship 2024 – 2027)
• Chelsea Reitzel, MSc Student (part-time), 2022 – present
• Davier Gutierrez-Gongora, PhD Candidate, 2022 – present (Ontario Graduate Scholarship 2022; EvoFunPath Fellow 2022 – 2024; International Graduate Research Award 2022 – 2025)
• Michael Woods, PhD Candidate, 2022 – present (MITACS Accelerate Internship 2021 – 2022)
• Kerry Woolnough (co-supervisor), PhD Bioinformatics Candidate, 2021 – present
• Boyan Liu, PhD Candidate, 2021 – present (NSERC CREATE EvoFunPath Fellow 2021 – 2023)
• Jacqueline Thomson (co-supervisor), PhD Candidate, 2020 – present

Undergraduate students

• Julia Burjanik-Novak, Work Study Student, 2024 – present
• Julia Kyriacou, Work Study Student, 2024 – present
• Isabella De la Torre, Work Study Student, 2024 – present
• Lauren Segeren, 4^th-year Research Project student, 2023 – present

Research Support

• Norris Chan, MSc, Research Technician, 2022 – present
• Dr. Jason McAlister, Research Manager, 2020 – present

Visiting Scholar

• Dr. Niels Maywald, Post-doctoral researcher, University of Hohenheim, Germany, 2025 – present
• Dr. Sanaz Ramezanpour, Professor at Gorgan University, Iran, 2024 – present

Previous trainees

Post-doctoral fellows

• Nasser Ibrahim, PhD, 2024
• Kholoud Shaban, PhD, 2023 – 2024

Graduate students

• Mary Adofo, MSc, 2025 (NSERC CREATE EvoFunPath Fellow 2023 – 2024)
• Brianna Ball, PhD, 2024 (NSERC Canada Graduate Scholarship – Doctoral 2022; Ontario Graduate Scholarship 2020, 2021, 2022; NSERC Canada Graduate Scholarship – Masters 2020; EvoFunPath Fellow 2021 – 2023)
• Jing Sun, Master of Biotechnology, 2024
• Madison Van Zyl, Master of Biotechnology, 2024
• Maheen Siddiqui, Master of Bioinformatics, 2024
• Ben Muselius, PhD, 2024 (Charbonneau Post-doctoral fellowship, University of Calgary)
• Wilson Li (co-supervisor), MSc, 2024
• Nicholas Prudhomme, PhD, 2020 – 2023 (Ontario Graduate Scholarship 2021; 2022)
• Tia Rizakos, MSc, 2023
• Oindrilla Chakrabarty, Master of Biotechnology, 2023
• Sarah Thompson, Master of Biotechnology, 2023
• Esther Olabisi-Adeniyi, Master of Bioinformatics, 2023
• Omar Amin, Master of Bioinformatics, 2023
• Thomas Papp-Simon, Master of Bioinformatics, 2023
• Arjun Sukumaran, PhD, 2023 (Ontario Graduate Scholarship 2021; Queen Elizabeth II Graduate Scholarship in Science & Technology 2020)
• Fouad Raouf-Alkadhimi, Master of Biotechnology, 2022
• Reid Buchanan, MSc, 2023 (MITACS Accelerate Internship 2020 – 2021)
• Jarod Morgenroth-Rebin, MSc, 2023
• Anchitaa Ghag (co-supervisor), Master of Bioinformatics, 2022
• Natalie Kim (co-supervisor), MSc Bioinformatics, 2021 – 2022 (NSERC Canada Graduate Scholarship – Masters 2021)
• Lilianne Gee (co-supervisor), MSc, 2022 (Current position: Research Technician at National microbiology Laboratory, Winnipeg, MB)
• Arianne Bermas, MSc, 2021 (Current position: Data Analyst)
• Syed Ali, (co-supervisor) Master of Bioinformatics, 2021

Undergraduate students

• Ben Smith, Work Study Student, 2023 – 2024
• Harjot Atwal, Thesis Project Student, Work study student, 2023 – 2024
• Mariya Bohra, Thesis Project Student, 2023 – 2024
• Effie Honeywell, Thesis Project Student, Co-op, & Work Study Student, 2020 – 2024
• McKenna Williams, Work Study Student, 2023
• Dana Clarisse Antivola, Work Study Student, 2023
• Matthew Quinn, NSERC Undergraduate Summer Research Assistant, 2023
• Kayla Smith, Literature Project Student, 2023
• Alexandra Glennie, Thesis Project Student, 2023
• Ashley Davidson-Eke, Thesis Project Student, 2023
• Samiha Kazi, NSERC Undergraduate Summer Research Assistant, Thesis Project Student, Co-op Student, 2021 – 2023
• Kiyan Kheradvar, CBS Undergraduate Research Awardee, Thesis Project Student & Work study, 2022 – 2023
• Jiaxi Lu, One Health Institute International Summer Studentship, Thesis Project Student & Work Study, 2022 – 2023
• Madeleine O’Connor, Work Study Student, 2022 – 2023
• Ryan Rozniak, Work Study Student, 2022 – 2023
• Breanne Murray, Thesis Project Student, 2022 – 2023
• Oscar Gonzalez, MITACS Globalink Studentship, 2022
• Nicole Hendriks, Literature Project Student, 2022
• Oriana Robinson, Thesis Project Student, 2021 – 2022, Graduated 2022
• Siobhan O’Connor, Thesis Project Student, 2021 – 2022, Graduated 2022
• Christina Zanetti, Thesis Project Student, 2021 – 2022, Graduated 2022
• Thuy Lisa Tran, Thesis & Literature Project Student, 2021 – 2022, Graduated 2022
• Mercy Akinsola, Thesis Project Student, 2021 – 2022, Graduated 2022
• Manuela Modrakova, Thesis Project Student, 2021 – 2022, Graduated 2022
• Divya Vurrabindi, Literature Project Student, 2021 – 2022, Graduated 2022
• Daniela Samuel, Undergraduate Research Assistant, Intern, Work Study Student, 2020 – 2022
• Payton Curtis, Co-op Student, 2021 – 2022
• Kushal Gandhi, Undergraduate Research Assistant & Thesis Project Student, 2021 – 2022, Graduated 2022
• Alicom Ochere, Work Study Student, 2021 – 2022, Graduated 2022
• Marsha Lane, Work Study Student, 2021 – 2022, Graduated 2022
• Hannah West, Co-op Student, 2020 – 2021 (NSERC Undergraduate Summer Research

Award 2021)

• Maggie Cumming, Work Study Student, 2020 – 2021
• Sarah Renaud, Thesis Project Student, 2021
• Michael Prudencio-Brunello, Thesis Project Student, 2021, Graduated 2021
• Anthony Hendriks, Canada Jobs Summer Intern, 2021
• Jake Brill, Thesis Project Student, 2021, Graduated 2021
• Shay-Lynn Durand, Literature Project Student, 2021, Graduated 2021
• Kristen Haydock, Literature Project Student, 2021, Graduated 2021
• Morgan Langille, Thesis Project Student & Work Study Student, 2020 – 2021, Graduated 2021
• Danisha Johal, Undergraduate Research Assistant, Co-op Student, Thesis Project Student, 2020 – 2021, Graduated 2021
• Taylor Ross, Work Study Student, Thesis Project Student, 2019 – 2021, Graduated 2022
• Jacob Hamilton-Rowe, Thesis Project Student, 2020 – 2021, Graduated 2021
• Leah Horlings, Thesis Project Student, 2020, Graduated 2021
• Edison Zheng, Work Study Student, Thesis Project Student, 2019 – 2020, Graduated 2021
• Charmaine Retanal, Literature Project Student, 2020, Graduated 2021
• Marie Pinto, Literature Project Student, 2020, Graduated 2021
• Natalie Pagdiwala, Literature Project Student, 2020, Graduated 2021
• Sagal Dirie, Thesis Project Student, 2020, Graduated 2021
• Nakshdeep Grewal, Literature Project Student, 2020, Graduated 2020
• Nadolina Brajuka, Work Study Student, 2019 – 2020, Graduated 2020
• Ben Muselius, Thesis Project Student, 2019 – 2020, Graduated 2024
• Rebecca Stevens-Green, Thesis Project Student, 2019 – 2020, Graduated 2020
• Jason Yeung, Work Study Student, Thesis Project Student, 2018 – 2020, Graduated 2020
• Elizabeth Woroszchuk, Undergraduate Research Assistant, Thesis Project Student, 2019 – 2020, Graduated 2020
• Lilianne Gee, Work Study Student, Thesis Project Student, 2018 – 2019
• Ammar Afaq, Thesis Project Student, 2019, Graduated 2020
• Duncan Carruthers-Lay, Thesis Project Student, 2018 – 2019, Graduated 2019
• Brianna Ball, Thesis Project Student, 2018, Currently PhD Candidate

Research support

• Wan Yun, Research technician, 2024
• Esther Olabisi-Adeniyi, MBINF, Bioinformatician, 2023 – 2024
• Omar Amin, Bioinformatician, 2023
• Samanta Pladwig, MSc, Research Technician, 2020 – 2023
• Anchitaa Ghag, MBINF, Scientific Writer, 2022
• Amy Hoff, Bioinformatics Research Assistant, 2021

Visiting Scholar

• Jovany Betancourt, MD/PhD Student (supervisor: Dr. Kirsten Nielsen; University of Minnesota), United States, 2024
• Viola Harder, PhD student (supervisor: Dr. Rebecca Shapiro, University of Guelph), Canada, 2023
• Manon Henry, PhD student (supervisor: Dr. Adnane Sellam; University of Montreal), Canada, 2023
• Marie-Laurence Lemay, PhD student (supervisor: Dr. Sylvain Moineau; Laval University), Canada, 2020

MICR*3230 Immunology

MICR*2420 Introduction to Microbiology

MCB*6500/*7500 MSc/PhD Research Topics in MCB

BINF*6890 Topics in Bioinformatics

MCB*6310 Advanced Topcs in Molecular and Cellular Biology

MCB*6700 Special Topics in Systems Biology

BINF*6999 Bioinformatics Master's Project