Azrieli Foundation (RFA): The Neuroimmune System and Brain Development


Azrieli Foundation

For More Information

For additional information, please visit the Azrieli Foundation website for

  • Program guidelines
  • Application forms
  • Evaluation criteria


The Azrieli Foundation Grants Program seeks to support hypothesis-driven, mechanistic research projects that explore the role played by inflammatory and immune processes in neural development and their effects on the pathophysiology of neurodevelopmental disorders (NDDs). The long-term vision is that discoveries made possible by this RFA could lead to the development of mechanism-based interventions that address the fundamental molecular and physiological features that underlie neurodevelopmental conditions.

Topic Eligibility examples of relevant research include, but are not limited to:

  • Effect of infection, immune/inflammatory pathways on embryonic/fetal brain development
  • Anatomic, cellular and mechanistic characterization of neuro-immune interface in brain developmental processes
  • Role of immune/inflammatory pathways related to the gut-brain axis (including microbiome) on brain development
  • Role of microglia in brain development (ex: synaptic pruning, connectivity, oligodendrogenesis)
  • Studies of the mechanistic impact on brain of neuro-immune interactions as they relate to high confidence risk factors associated with NDDs in humans


Applications may be submitted by individual researchers or teams. Inter-institutional collaborative proposals are strongly encouraged. Nominated Principal Applicants, and Co-applicants (who intend to share funding) must be independent researchers at accredited Canadian Universities or Research Institutes with Registered Charitable Organization designation. Team applications can also include collaborators (who do not request funding from this RFA), from any jurisdiction.

Funding Availability

Expect to fund top five applications

Maximum Project Value

Individual or team projects will be funded to a maximum of CAD $150,000 per year

Indirect Costs


Project Duration

Three years

Special Notes

Please note that research activities carried out in the context of COVID-19 need to adhere to the University of Guelph COVID-19 research principles, policies, guidelines and processes as they may be updated from time to time and communicated on the Office of Research web-page.


If College-level review is required, your College will communicate its earlier internal deadlines.

External Deadline

Letter of Intent: NPI to submit Letter of Intent using the portal. See attached LOI information and application manual.



Internal Deadline

Application: NPI to provide a copy of the application along with a complete OR5 form to

External Deadline

Application: NPI to submit application via the portal. See attached Application Manual.


File Letter of Intent56.94 KB
PDF icon Application Manual566.44 KB
For Questions, please contact

Office of Research

Ornella McCarron, Grants Officer
Research Services Office
519-824-4120 x52832

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