Bettina Kalisch

• The primary focus of our research program is to elucidate and compare the mechanisms involved in the regulation of expression of genes that are important in cholinergic neuron function and Alzheimer Disease.
Specifically, we are investigating nerve growth factor signal transduction pathways and the role of nitric oxide in the regulation of expression of cholinergic genes, amyloid precursor protein, tau, low density lipoprotein receptor-related protein and apolipoprotein E. The effects of oxidative stress on the regulation of expression of these genes is also being investigated.

• Jonah Rikkerink - MSc
• Daniel Stenn - MSc

• Hamilton TJ, Kalisch BE. (2025) Beyond vision loss: the impact of glaucoma on the brain. Front Cell Dev Biol. 13:1588561. https://doi.org/10.3389/fcell.2025.1588561
• Mitchnick KA, Creighton SD, Johal KS, Anoop S, Kalisch BE, Stefanelli G, Winters BD. (2025) Double dissociation between the involvement of Gadd45α and Gadd45β/γ in the perirhinal cortex and hippocampus of male rats for object memory. Neurobiol Learn Mem. 222:108113. https://doi.org/10.1016/j.nlm.2025.108113
• Steinfield SR, Stenn DF, Chen H, Kalisch BE. (2025) A review of the clinical progress of CT1812, a novel sigma-2 receptor antagonist for the treatment of Alzheimer's disease. Pharmaceuticals (Basel). 18:659. https://doi.org/10.3390/ph18050659
• Hickey JP, Collins AE, Nelson ML, Chen H, Kalisch BE. (2024) Modulation of oxidative stress and neuroinflammation by cannabidiol (CBD): Promising targets for the treatment of Alzheimer's disease. Curr Issues Mol Biol. 46:4379-4402. https://doi.org/10.3390/cimb46050266
• Hamilton TJ, Kalisch BE. (2024) Ocular changes in Alzheimer’s disease. Global Translational Medicine 3:4094. https://doi.org/10.36922/gtm.4094
• Nelson ML, Pfeifer JA, Hickey JP, Collins AE, Kalisch BE. (2023) Exploring rosiglitazone's potential to treat Alzheimer's disease through the modulation of brain-derived neurotrophic factor. Biology (Basel). 12:1042. https://doi.org/10.3390/biology12071042
• Nguyen VP, Collins AE, Hickey JP, Pfeifer JA, Kalisch BE. (2023) Sex differences in the level of homocysteine in Alzheimer's disease and Parkinson's disease patients: A meta-analysis. Brain Sci. 13:153. https://doi.org/10.3390/brainsci13010153
• Collins AE, Saleh TM, Kalisch BE. (2023). VANL-100 attenuates beta-amyloid-induced toxicity in SH-SY5Y cells. Int. J. Mol. Sci. 24:442. https://doi.org/10.3390/ijms24010442
• Collins AE, Saleh TM, Kalisch BE. (2022) Naturally occurring antioxidant therapy in Alzheimer's disease. Antioxidants (Basel). 11:213. https://doi.org/10.3390/antiox11020213