Jeff Caswell

• Pathogenesis of infectious diseases of the lung
• Innate immune responses in defence against opportunistic infections
• Pathology of the respiratory system

My research interests centre on innate resistance to opportunistic bacterial infection, and on the pathogenesis of Mycoplasma bovis pneumonia and other infectious diseases of the respiratory system. Bacterial pneumonia is a major cause of death and production loss in cattle, yet most animals are innately resistant to infection with the bacteria that cause pneumonia. Stress and viral infection are two well-recognized predisposing causes of bacterial pneumonia, yet much remains to be learned of how these factors impair lung defences. Pneumonia in cattle is a useful system for investigating how stress and viral infection influence the interaction between the host, the pathogen, and the environment. Potential applications include identification of animals at risk of developing bacterial pneumonia, better identification of risk factors for disease susceptibility; and augmentation of innate resistance through strategies of animal management, nutrition, or therapeutic intervention other than antibiotics.

Current research includes:

• Pathogenesis of pneumonia caused by Mycoplasma bovis in feedlot cattle
• How bovine respiratory disease risk factors dyregulate immune responses in the respiratory tract to favour harmful disease outcomes

Undergraduate

• VETM*3120 Veterinary Histology and General Pathology:

1. Inflammation, tissue repair and immune-mediated disease
2. Gross pathology description and interpretation

• VETM*4490 Systems Pathology: Respiratory and cardiovascular pathology
• Phase IV: Anatomic Pathology rotation
• PATH 3610 Principles of Disease: Respiratory disease

Graduate

• PABI*6080/6090/6091 Diagnostic Pathology I, II, III: Respiratory and cardiovascular pathology
• PABI*6104 Mechanisms of Disease: Inflammation

• Teeba Ismail - MSc
• Ryan Kia - PhD
• Victoria Lee-Valerio – DVSc
• Zahra Nikousefat - PhD
• Saeid Tabatabaei - PhD
• Ritu Verma – PhD (co-advisor)
• James Yan – PhD (co-advisor)
• Ananda Pires – PhD (co-advisor)

• PhD: Jessica Joshua (co-adv), Laura Bassel, Ksenia Vulikh, Chandrika Senthilkumaran, Heather Chalmers (co-adv), Khaled Taha Abdelaziz, Gord Mitchell, Joanne Hewson.
• DVSc: Luke Haydock, Dominique Comeau, Carmon Co (co-adv), Laura Bourque, Laetitia Tatiersky, Fernanda Castillo, Susan Newbigging, Sameh Youssef, Mihai Gagea, Muthafar al-Haddawi, Geoffrey Wood, Erin Southorn
• MSc: Ksenia Vulikh, Laura Siracusa, Lesley Berghuis, Sarah Scapinello (co-adv), Jennifer Beveridge.
• MBS: Juntian Bu, Jeremy Chang, Priyatharshini Ramesh co-adv).
• GDipl: Rachel Geisel (co-adv), Alex Loretti (co-adv), Mihai Gagea.

1. Caswell JL and Williams K. The respiratory system. In: Jubb, Kennedy, and Palmers Pathology of Domestic Animals, 5th ed. Maxie MG et al. (eds). Pp. 523-655. Elsevier, Edinburgh, 2007.

2. Mitchell GB, Clark ME, Siwicky M, Caswell JL. Stress alters the cellular and proteomic compartments of bovine bronchoalveolar lavage fluid. Vet Immunol Immunopathol 125: 111-125, 2008.

3. Caswell JL and Archambault M. Mycoplasma bovis pneumonia in cattle. Animal Health Research Reviews (2007), 8:161-186.

4. Mitchell GB, Clark ME, Caswell JL. Alterations in the bovine bronchoalveolar lavage proteome induced by dexamethasone. Vet.Immunol.Immunopathol. 118: 283-293, 2007.

5. Mitchell GB, al-Haddawi M, Clark ME, Beveridge JD, Caswell JL. Effect of corticosteroids and neuropeptides on the expression of defensins in bovine tracheal epithelial cells. Infection and Immunity 75: 1325-1334, 2007.

6. Al-Haddawi M, Mitchell GB, Clark ME, Wood RD , Caswell JL. : Impairment of innate immune responses of airway epithelium by infection with bovine viral diarrhea virus. Vet.Immunol.Immunopathol. 116: 153-162, 2007.

7. Weingartl HM, Berhane Y, Caswell JL, Loosmore S, Audonnet J-C, Roth JA, Czub M. Recombinant Nipah virus vaccines protect pigs against challenge. Journal of Virology 80:7929-38, 2006.

8. Gagea MI, Bateman MG, van Dreumel T, McEwen BJ, Carman S, Archambault M, A. Shanahan R, and Caswell JL. Diseases and pathogens causing mortality in Ontario beef feedlots. J Vet Diag Invest 18: 8-28, 2006.

9. Gagea MI, Bateman MG, Shanahan R, van Dreumel T, McEwen BJ, Carman S, Archambault M, A. and Caswell JL. Naturally occurring Mycoplasma bovis pneumonia and polyarthritis in feedlot beef calves. J Vet Diag Invest 18: 29-40, 2006.

10. Caswell JL, Middleton DM, Sorden SD, and Gordon JR. Expression of the neutrophil chemoattractant interleukin-8 in the lesions of bovine pneumonic pasteurellosis. Veterinary Pathology 35: 124-131, 1998.

11. Caswell JL, Yager JA, Parker WM, and Moore PF. A prospective study of the immunophenotype and temporal changes in the histologic lesions of canine demodicosis. Veterinary Pathology 34: 279-287, 1997.

12. Bassel LL, Kaufman EI, Alsop SNA, Sergejewich L, Vulikh K, Stinson KJ, Siracusa LR, Buchan J, Hewson J, Sharif S, Caswell JL. The effect of aerosolized bacterial lysate on experimentally induced Mannheimia haemolytica pneumonia in calves. Can J Vet Res. 2022 Apr;86(2):85-92.

13. Schulman FY, Roccabianca P, Avallone G, Bertram CA, Chalkley M, Chambers JK, Donovan TA, Foster RA, Meuten D, Porcellato I, Priestnall SL, Rasotto R, Uchida K, Webster JD, Wood GA, Caswell JL. Reporting guidelines for manuscripts on tumor prognosis. Vet Pathol. 2022 May;59(3):397-398.

14. Baquero M, Vulikh K, Wong C, Domony M, Burrows D, Marom D, Perez-Casal J, Cai HY, Caswell JL. Effects of inflammatory stimuli on responses of macrophages to Mycoplasma bovis infection. Vet Microbiol. 2021 Nov;262:109235.

15. Bassel LL, Kaufman EI, Alsop SA, Buchan J, Hewson J, McCandless EE, Tiwari R, Sharif S, Vulikh K, Caswell JL. Effect of aerosolized bacterial lysate on development of naturally occurring respiratory disease in beef calves. J Vet Intern Med. 2021 Jan;35(1):655-665.

16. Bassel LL, Co C, Macdonald A, Sly L, McCandless EE, Hewson J, Tiwari R, Sharif S, Siracusa L, Clark ME, Caswell JL. Pulmonary and systemic responses to aerosolized lysate of Staphylococcus aureus and Escherichia coli in calves. BMC Vet Res. 2020 May 29;16(1):168.

17. Bassel LL, Tabatabaei S, Caswell JL. Host tolerance to infection with the bacteria that cause bovine respiratory disease. Vet Clin North Am Food Anim Pract. 2020 Jul;36(2):349-359.

18. Vulikh K, Bassel LL, Sergejewich L, Kaufman EI, Hewson J, MacInnes JI, Tabatabaei S, Caswell JL. Effect of tracheal antimicrobial peptide on the development of Mannheimia haemolytica pneumonia in cattle. PLoS One. 2019 Nov 26;14(11):e0225533.

19. Bassel LL, Kaufman EI, Alsop SNA, Stinson KJ, Hewson J, Sharif S, Vulikh K, Siracusa L, Clark ME, Caswell JL. Development of an aerosolized Mannheimia haemolytica experimental pneumonia model in clean-catch colostrum-deprived calves. Vet Microbiol. 2019 Jul;234:34-43.

20. Cai HY, McDowall R, Parker L, Kaufman EI, Caswell JL. Changes in antimicrobial susceptibility profiles of <i>Mycoplasma bovis</i> over time. Can J Vet Res. 2019 Jan;83(1):34-41.

21. Caswell JL, Bassel LL, Rothenburger JL, Gröne A, Sargeant JM, Beck AP, Ekman S, Gibson-Corley KN, Kuiken T, LaDouceur EEB, Meyerholz DK, Origgi FC, Posthaus H, Priestnall SL, Ressel L, Sharkey L, Teixeira LBC, Uchida K, Ward JM, Webster JD, Yamate J. Observational Study Design in Veterinary Pathology, Part 2: Methodology. Vet Pathol. 2018 Nov;55(6):774-785.

22. Caswell JL, Bassel LL, Rothenburger JL, Gröne A, Sargeant JM, Beck AP, Ekman S, Gibson-Corley KN, Kuiken T, LaDouceur EEB, Meyerholz DK, Origgi FC, Posthaus H, Priestnall SL, Ressel L, Sharkey L, Teixeira LBC, Uchida K, Ward JM, Webster JD, Yamate J. Observational Study Design in Veterinary Pathology, Part 1: Study Design. Vet Pathol. 2018 Sep;55(5):607-621.

23. Bassel LL, Caswell JL. Bovine neutrophils in health and disease. Cell Tissue Res. 2018 Mar;371(3):617-637.

24. Taha-Abdelaziz K, Bassel LL, Harness ML, Clark ME, Register KB, Caswell JL. Cilia-associated bacteria in fatal Bordetella bronchiseptica pneumonia of dogs and cats. J Vet Diagn Invest. 2016 Jul;28(4):369-76.

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