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    Dr. Paula Miotto

    A photo of Dr. Paula Miotto

    CIHR Tier II Canada Research Chair in Immuno-Metabolism and Tissue Communication, Assistant Professor

    College of Biological Science, Department of Human Health Sciences

    pmiotto@uoguelph.ca
    PubMed
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    ResearchGate
    Office
    Animal Science and Nutrition (ANNU), Room 243
    Laboratory
    ANNU 316

    Profile

    Paula Miotto is a Canada Research Chair and Assistant Professor in the Department of Human Health Sciences. She joined the University of Guelph in May 2026, after completing her post-doctoral studies in the Department of Anatomy and Physiology at the University of Melbourne, Australia. During this time, she was supported by an Australian National Health and Medical Research Council (NHMRC) Emerging Leadership 1 Investigator grant (fellowship), and was previously supported by fellowships through CIHR and NSERC. Her research has been funded through grants awarded by the NHMRC, Diabetes Australia, and The University of Melbourne.

    Education

    • Post-Doctoral Fellow – The University of Melbourne, Australia, 2018-2026
    • PhD – The University of Guelph, 2018
    • MSc – Brock University, 2014
    • Hon. BKIN – Brock University, 2012

    Research

    My research focuses on the role of secreted proteins and/or small extracellular vesicles in regulating cell signalling events (acute) and metabolic adaptations (chronic) in response to exercise and metabolic disease. Generally, this includes research focused on obesity/insulin resistance, aging, metabolic-associated fatty liver disease (MASLD), and diabetes (Type I and II). My lab integrates omics approaches (phosphoproteomics, proteomics, lipidomics) with metabolic function (e.g., carbohydrate/lipid metabolism using tracer assays, mitochondrial respiration) using models that range from cells to animals and human tissues.

    Selected Publications

    1. Miotto PM, Yang CH, Keenan SN, De Nardo W, Beddows CA, Fidelito G, Dodd GT, Parker BL, Hill AF, Burton PR, Loh K, and Watt MJ. (2024). Liver-derived extracellular vesicles improve whole body glycaemic control via inter-organ communication. Nature Metabolism, 6(2): 254-272.

    1. De Nardo, W, Bayliss J, Elahee Doomun SN, Lee O, Miotto PM, Suriani ND, Nie S, Leeming M, Mirando DA, De Souza DP, and Watt MJ. Effect of free fatty acids on TGF-B1 mediated fibrogenesis in hepatic stellate cells. Molecular Metabolism, 104:102309.

    1. Miotto PM, Bayliss J, Fidelito G, Bell JR, Delbridge LMD, Watt MJ, and Montgomery MK. Proteomic analysis reveals preferential secretion of inner mitochondrial membrane proteins from the diabetic heart in the presence of mitochondrial oxidative stress. AJP Endocrinology and Metabolism, 329(6):E897-E911.

    1. De Nardo W, Lee O, Johari Y, Bayliss J, Pensa M, Miotto PM, Keenan SN, Ryan A, Rucinski A, Svinos TM, Ooi GJ, Brown WA, Kemp W, Roberts SK, Parker BL, Montgomery MK, Larance M, Burton PR, and Watt MJ. (2025). Integrated liver-secreted secreted and plasma proteomics identify a predictive model that strategies MASH. Cell Reports Medicine, 6(5): 102085.

    1. Anari M, Karimkhanloo H, Nie S, Dong L, Fidelito G, Bayliss J, Keenan SN, Slavin J, Lin S, Cheng Z, Lu J, Miotto PM, De Nardo W, Devereux CJ, Williamson NA, Watt MJ, and Montgomery MK. (2024). Lipidome profiling in advanced metabolic liver disease identifies phosphatidylserine synthase 1 as a regulator of hepatic lipoprotein metabolism. Cell Reports,43(12): 115007.

    1. Karimkhanloo H, Keenan SN, Bayliss J, De Nardo W, Miotto PM…Montgomery MK. (2023). Mouse strain dependent variation in metabolic associated fatty liver disease (MAFLD): a comprehensive resource tool for pre-clinical studies. Scientific Reports, 13(1):4711.

    1. Blazev R*, Carl CS*, Ng YK*, Molendijk J, Voldstedlund CT, Zhao Y, Xiao D, Kueh AJ, Miotto PM….ParkerBL. (2022). Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function. Cell Metabolism, 34(10), 1561-1577.

    1. De Nardo W, Miotto PM, Bayliss J, Nie S, Keenan SN, Montgomery MK, and Watt MJ. (2022). Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan 4 as a regulator of hepatic lipid accumulation. Molecular Metabolism, 60:101491.

    1. Montgomery MK, Bayliss J, Nie S, De Nardo W, Keenan SN, Miotto PM…Watt MJ. (2022). Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control. Nature Communications, 10:13(1) 1259.

    1. Miotto PM, Dao GM, and Brunetta HS. (2021). Fission accomplished: Uncovering the role of Drp1 in regulating mitochondrial dysfunction and age-related muscle atrophy. The Journal of Physiology, 599(21), 4745 4747.(Commentary article).

    1. Morgan PK*, Huynh K*, Pernes G*, Miotto PM, Mellet NA, Giles C, Meikle PJ, Murphy AJ, and Lancaster GI. (2021). Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools. Journal of Biological Chemistry, 297(6).

    1. Boer A, Keenan SN, Miotto PM, Holst JJ, and Watt MJ. (2021). GIP receptor deletion in mice confers resistance to HFD-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism. AJP Endocrinology and Metabolism, 320(4): E835-E845.

    1. Hardee JP, Martines KJB, Miotto PM…Lynch GS. (2020). Metabolic remodelling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity. Molecular Metabolism, 45:101157.

    1. Petrick HL, Foley KP, Zlitni S, Brunetta HS, Paglialunga S, Miotto PM, Politis-Barber V, O’Dwyer C, Philbrick DJ, Fullerton MD, Schertzer JD, and Holloway GP. (2020). Adipose tissue inflammation is directly linked to obesity-induced insulin resistance, while gut dysbiosis and mitochondrial dysfunction are not required. Function, 1 (2):zqaa013.

    1. Miotto PM, Petrick HL, and Holloway GP. (2020). Acute insulin deprivation results in altered mitochondrial substrate sensitivity conducive to greater lipid transport. AJP Endocrinology and Metabolism, 319(2): E345 E353.

    1. Watt MJ, Miotto PM, De Nardo W, and Montgomery MK. The liver as an endocrine organ – linking NAFLD and insulin resistance. Endocrine Reviews. 40(5), 1367-1393.

    1. Miotto PM, LeBlanc PJ and Holloway GP. (2018). High-fat diet causes mitochondrial dysfunction as a result of impaired ADP sensitivity. Diabetes, 67, 2199-2205. *Accompanied by a Commentary article.

    1. Miotto PM, McGlory C, Holloway TM, Phillips SM and Holloway GP. (2018). Sex differences in mitochondrial respiratory function in human skeletal muscle. AJP Regulatory, Integrative, & Comparative Physiology 314, R909-R915. *Selected as an APS Select article and is covered in 1 Commentary and 1 editorial.

    1. Miotto PM, Steinberg GR and Holloway GP. (2017). Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise. Biochemical Journal, 474, 557-569. *Selected as an F1000 Prime recommended article.