Dr. Marica Bakovic
Associate Professor

Office: ANNU 346
Ext: 53764
Lab: ANNU 309
Ext: 56717

Education

B.Sc. - Belgrade
M.Sc. - Belgrade
Ph.D. - Alberta

Research

Regulation of genes involved in choline transport and phospholipid metabolism; nutrient transporters and kinetics of membrane transport; molecular and cell biology of lipids; the effect of nutrients on protein synthesis and gene expression. Nutritional genomics (nutrigenomics) of risk factors for cardiovascular disease and insulin resistance

Selected Publications

Zhu L., Michel V., & Bakovic M (2009) Regulation of the mouse CTP:phosphoethanolamine cytidylyltransferase gene Pcyt2 during myogenesis, Gene 447(1):51-9.

Fullerton M.D. Hakimuddin F., Bonen A., & Bakovic M. (2009) The development of a metabolic disease phenotype in CTP:phosphoethanolamine cytidylyltransferase deficient mice, J. Biol. Chem . 284(38):25704-13.

Michael V. & Bakovic M. (2009) The solute carrier 44A1 is a mitochondrial protein and mediates choline transport, FASEB J. 23(8):2749-58.

Zhu L.; Johnson C. & Bakovic M (2008) Stimulation of the human CTP: phosphoethanolamine cytidylyltransferase gene by early growth response protein 1. J Lipid Res. 49(10):2197-211.

Zhu L. & Bakovic, M (2008) Liver X receptor agonists inhibit the phospholipid regulatory gene CTP:phosphoethanolamine cytidylyltransferase Pcyt2. Res Lett Biochem . Vol. 2008, ID 801849-5p).

Wood K.C., Fullerton M.D., El-Sohemy A. & Bakovic M (2008) Interactions between hepatic lipase and apolipoprotein E gene polymorphisms affect serum lipid profiles of healthy Canadian adults. Appl Physiol Nutr Metab. 33( 4): 761-8.

Fullerton MD, Hakimuddin F & Bakovic M (2007) Developmental and metabolic effects of disruption of the mouse CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2). Mol Cell Biol . 27:3327-3336

Bakovic M. Fullerton MD & Michel V (2007) Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2). Biochem Cell Biol . 85:283-300.

Tie A & Bakovic M (2007) Alternative splicing of CTP: Phosphoethanolamine cytidylyltransferase produces two isoforms that differ in catalytic properties. J Lipid Res 48(10):2172-81.

Michel V & Bakovic M (2007) Lipid rafts in health and disease. Biol Cell 99:129-140.

Teaching

HBNS*6440 Nutrition and Gene Expression
NUTR*4360 Current Issues in Nutrigenomics

Grad Students

K. Chiswell (MSc student)
B. Deschambault (PhD student)
J.P. Girardi (MSc student)
S. Guruge (MSc student)