Dr. Terry Graham
Office: ANNU 342A
Lab: ANNU 307
From the beginning of my studies I was fascinated by physiology and metabolism. For me, this area integrated anatomy and biochemisty and made all of the natural sciences come together in an understanding of the human body. I did my graduate work in physiology at Queen's University in various aspect of muscle metaoblism and then was a postdoctoral fellow with Bengt Saltin in Copenhagen. Subsequently I came to Guelph in 1976 and have spent my career here. My 'traditional' area of investigation is the regulation of muscle glycogen and lactate metabolism. I have explored many other topics during my career, but always come back to carbohydrate homeostasis. At Guelph I realized that the science discipline that my work was missing was nutrition and progressively brought more and more aspects of this into my investigations. I have come to appreciate the incredible degree of interaction between physical activity and nutrition and am convinced that one can not truly understand or study one without the other. Traditionally this has been thought to apply mainly to the nutritional habits of elite athletes. Now it is apparent that the interactions are critical to every person and are more important to sedentary people than to athletes. Muscle is a dominant tissue in whole body metabolism and a single bout of exercise can dramatically alter the metabolic responses to a meal and these in turn impact on our longterm health. Nutrition and physical activity are intimately linked to many of our critical health care issues.
B.A. - Queens Universitry
BPHE - Queens Universitry
M.Sc. - Queens Universitry
Ph.D. - Queens Universitry
Dr. Graham's research has had an extensive program examining the impact of caffeine or coffee ingestion on carbohydrate metabolism and insulin sensitivity. However, now it is focused on muscle glycogen with a particular focus on the roles of regulatory proteins that are associtaed with the glycogen granules. This critical store of carbohydrate exists in highly organized granules in specific locations within the cell. There is a large group of proteins/enzymes that bind to the granule and are vital to the regulation. The nature of these actions are very likely to be key to carbohydrate regulation in not only exercise, but in health and disease states.
J Turnbull, J-M Girard, N Pencea, X Zhao, T E Graham, P Wang,C A Ackerley, and BA Minassian. Lafora Bodies in Skeletal Muscle are Fiber Type Specific Neurology. (in press)
Beaudoin, M-S, and TE Graham. Methylxanthines and human health: epidemiological and experimental evidence. In Methylxanthines. Handbook for Experimental Pharmacology. Edited by B Fredholm. Springer. 2011; (200):509-548.
Moisey, LL, Robinson, LE and TE Graham. Consumption of caffeinated coffee and a high glycemic index meal affects the postprandial metabolism of the second meal Br J Nutr. 103: 833-841, 2010.
T E Graham, Z Yuan, A Hill, R J Wilson. The regulation of muscle glycogen: the granule and its proteins. Acta Physiol Scand 199:489-498, 2010.
Graham, TE. Glycogen: an overview of possible regulatory roles of the proteins associated with the granule. Appl Physiol Nutr Metabol. 34: 488-492, 2009.
Dekker, M, Graham, T, Ooi, T C and L Robinson. Exercise prior to fat ingestion lowers fasting and postprandial VLDL and decreases adipose tissue IL-6 and GIP receptor mRNA in hypertriacylglycerolemic men. J Nutr Biochem 21(10):983-90, 2010.
TE Graham, DS Battram, F Dela, A El-Sohemy and F S L Thong. Does Caffeine alter muscle carbohydrate and fat metabolism during exercise? Appl Physiol Nutr Metabol 33: 1311-1318, 2008.
Mathai, AA, A Bonen, C R Benton, D L Robinson and T E Graham. The influence of exhaustive exercise and glycogen repletion on PGC-1alpha mRNA and protein expression J Appl Physiol: 105:1008-1015, 2008.
Moisey, LL, Kacker, S, Bickerton, AC, Robinson, LE, TE Graham. Caffeinated coffee consumption impairs blood glucose homeostasis in response to high and low glycemic index meals in healthy males. Am J Clin Nutr. 87: 1254-1261, 2008.
Benton, CR, JG Nickerson, J Lally, TE Graham, JJ Heikkila and A Bonen. Overexpression of PGC-1 alpha alters the expression of metabolic proteins in muscle and increases glucose transport and mitochondrial palmitate oxidation. J Biol Chem 283: 4228-4240, 2008.
Gusba, J E, R J Wilson, D L Robinson, and T E Graham. Interleukin-6 and its mRNA responses in exercise and recovery: relationship to muscle glycogen. Scand J Med Sci Sport 18: 77-85, 2008.
HBNS*6710 Advanced Topics in Nutrition and Exercise