Richard Manderville

Education and Employment

Post-doctorate: Bio-Organic Chemistry, University of Virginia, 1992-1995 (w/ Sidney M. Hecht)
Ph.D: Physical Organic Chemistry, Queen’s University, 1987-1992 (w/ Erwin Buncel)
B.Sc: Queen’s University, Kingston, Ontario, 1986

Research

Prof. Manderville’s research program focuses on the use of modified fluorescent DNA base replacements to study oligonucleotide binding to various ligands, including small molecule drugs, toxins, and biomolecules such as proteins. Key research themes include: 1) Biochemical toxicology, in which the modified base can initiate mutagenicity/carcinogenicity and its impact on DNA synthesis mediated by DNA polymerase enzymes is examined and 2) Biosensing applications, in which the modified base provides a fluorescent read-out for ligand binding by the modified oligonucleotide.

Highlights

• NSERC Discovery Grant Evaluation Group member for Chemistry (1504), 2021
• Member of the Editorial Advisory Board for Toxicology Research, 2020-present
• NSERC RTI Grant Evaluation Group Member for Chemistry (1504), 2015-2016
• Editorial Board Member for Toxins, 2011-present

Instrumentation

Optical spectroscopy (UV-vis, Fluorescence), DNA Synthesis to prepare chemically modified oligonucleotides with high-performance liquid chromatography (HPLC) for oligonucleotide purification