Dr. David J. Dyck

My interests in skeletal muscle metabolism and physiology were kindled as an undergraduate research assistant. I completed my Masters and Doctoral degrees at the University of Guelph, studying the mechanisms underlying the interaction between fat and carbohydrate utilization in contracting skeletal muscle. I then began my NSERC-funded postdoctoral fellowship at the University of Waterloo. During this tenure, I learned novel techniques for studying fat transport, and its metabolic fates in isolated skeletal muscle. I have continued to study muscle lipid metabolism since taking up my faculty position at Guelph in July 1998. My interests involve the hormonal regulation of muscle lipid metabolism, and in particular its’ dysfunction in the development of insulin resistance and diabetes. I currently have memberships in the Canadian and American Physiological Societies

B.Sc. - University of Guelph
M.Sc. - University of Guelph
Ph.D. - University of Guelph

My interests lie in the regulation of fat and carbohydrate metabolism in skeletal muscle, with a particular emphasis on the dysregulation that occurs in obesity and diabetes. Several cytokines released from skeletal muscle, including leptin and adiponectin, are known to significantly affect insulin response in peripheral tissues such as muscle. My research has focused on the effects of these adipokines on muscle lipid and carbohydrate metabolism, and particularly, how the muscle becomes resistant to their effects in obese models and with high fat feeding. The interaction of diet and exercise is also a point of interest in terms of the muscle's response to various hormones including insulin, leptin and adiponectin.

Ritchie IW, MacDonald T, Wright DC, Dyck DJ. Adiponectin is Sufficient, but Not Required, for Exercise-Induced Increases in the Expression of Skeletal Muscle Mitochondrial Enzymes. J. Physiol. Accepted March 26, 2014.

Tishinsky JM, De Boer AA, Dyck DJ, Robinson LE. Modulation of Visceral Fat Adipokine Secretion by Dietary Fatty Acids and Ensuring Changes in Skeletal Muscle Inflammation. Appl. Physiol. Nutr. Metab. 2014; 39(1):28-37.

Macdonald TL, Wan Z, Frendo-Cumbo S, Dyck DJ, Wright DC. IL-6 and Epinephrine have Divergent Fibre Type Effects on Intramuscular Lipolysis. J. Appl. Physiol. 2013; 115(10):1457-63.

Stefanyk LE, Bonen A, Dyck DJ. Fatty Acid Transport Proteins Chronically Relocate to the Transverse-Tubules in Muscle from Obese Zucker Rats but are Resistant to Further Insulin-Induced Translocation. Metabolism. 2013; 62(9):1296-304.

Gulli RA, Tishinsky JM, MacDonald T, Robinson LE, Wright DC, Dyck DJ. Exercise Restores Insulin, but not Adiponectin, Response in Skeletal Muscle of High-Fat Fed Rodents. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2012; 303(10):R1062-70.

Tishinsky JM, Robinson LE, Dyck DJ. Insulin-Sensitizing Properties of Adiponecton. Biochimie. 2012; 94(10):2131-6.

Stefanyk L, Bonen A, Dyck DJ. Insulin and Contraction-Induced Movement of Fatty Acid Transport Proteins to Skeletal Muscle Transverse-Tubules is Distinctly Different than to the Sarcolemma. Metabolism. 2012; 61(11):1518-22.

Tishinsky J, Gulli R, Mullen K, Dyck DJ, Robinson L. Fish Oil Prevents High Saturated Fat Diet-Induced Impairments in Adiponectin and Insulin Response in Rodent Soleus Muscle. Am. J. Physiol. 2012; 302:R598-605.

Stefanyk L, Gulli R, Ritchie I, Chabowski A, Snook L, Dyck DJ. Recovered Insulin Response by 2 Weeks of Leptin Administration is Associated with Restored AS160 Activation and Decreased Reactive Lipids. Am. J. Physiol. 2011; 301:R159-71.

Thrush AB, Harasim E, Chabowski A, Gulli R, Stefanyk L, Dyck DJ. A Single Prior Bout of Exercise Protects against Palmitate-Induced Insulin Resistance Despite an Increase in Total Ceramide Content. Am. J. Physiol. 2011; 300:R1200-8.

Ritchie I, Gulli R, Stefanyk L, Harasim E, Chabowski A, Dyck DJ. Restoration of Skeletal Muscle Leptin Response does Not Precede the Exercise-Induced Recovery of Insulin Stimulated Glucose Uptake in High-Fat Fed Rats. Am. J. Physiol. 2011; 300:R492-500.

Mullen K, Tishinsky J, Robinson L, and Dyck DJ. Skeletal Muscle Inflammation is Not Responsible for the Rapid Impairment in Adiponectin Response with High Fat Feeding in Rats. Am. J. Physiol. 2010; 299:R500-8.

Cresser J, Bonen A, Chabowski A, Stefanyk LE, Gulli R, Ritchie I, Dyck DJ. Oral Administration of a PPAR-δ Agonist to Rodents Worsens, Not Improves, Maximal Insulin-Stimulated Glucose Transport in Skeletal Muscle of Different Fibres. Am. J. Physiol. 2010; 299:R470-9.

Thrush AB, Brindley DN, Chabowski A, Heigenhauser GJ, Dyck DJ. Skeletal Muscle Lipogenic Protein Expression is Not Different between Lean and Obese Humans: A Potential Factor in Ceramide Accumulation. J. Clin. Endo. Metab. 2009; 94(12):5053-61.

Mullen K, Pritchard J, Ritchie I, Snook L, Chabowski A, Bonen A, Wright D, Dyck DJ. Adiponectin Resistance Precedes the Accumulation of Skeletal Muscle Lipids and Insulin Resistance in High Fat Fed Rats. Am. J. Physiol. 2009; 296: R243-51.

Dyck DJ, Heigenhauser GJF, Bruce CR. The Role of Adipokines as Regulators of Skeletal Muscle Fatty Acid Metabolism and Insulin Sensitivity. Acta Physiologica. 2006; 186:5-16.

Collier CA, Bruce CR, Smith AC, Lopaschuk G, Dyck DJ. Metformin Counters the Insulin-Induced Suppression of Fatty Acid Oxidation and Stimulation of Triacylglycerol Storage in Rodent Skeletal Muscle. Am. J. Physiol. 2006; 291:E182-9.

Bruce CR, Mertz V, Heigenhauser GJF, Dyck DJ. The Stimulatory Effect of Globular Adiponectin on Insulin-Stimulated Glucose Uptake and Fatty Acid Oxidation is Impaired in Skeletal Muscle from Obese Subjects. Diabetes. 2005; 54(11):3154-60.

• BIOL*1080 Biological Concepts of Health
• HK*4230 Advanced Study in Human Biology & Nutritional Sciences
• HK*4360 Research in Human Biology & Nutritional Sciences
• HK*4371/2 Research in Human Biology & Nutritional Sciences

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