Dr. Lawrence Spriet

Phone number: 
ext. 53745 (Office), ext. 53907 (Lab)
ANNU 354
ANNU 203

B.Sc. - University of Waterloo
M.Sc. - York University
Ph.D. - McMaster University

Dr. Spriet's basic research examines how skeletal muscle generates the large amounts of energy needed to exercise and compete in work and sport situations. The pathways that metabolize carbohydrate and lipid as fuel to produce energy are studied in human skeletal muscle. His practical research examines whether compounds that are purported to be "ergogenic" or work enhancing agents actually augment muscle metabolism and/or improve human performance (e.g. blood doping, creatine, carnitine, pyruvate, taurine, caffeine and omega-3 fatty acids). He also conducts hydration/sweat testing and research aimed at counteracting the effects of dehydration in athletes engaging in stop-and-go sports like ice hockey, basketball, and soccer.

Jannas-Vela, S, K Roke, S Boville, DM Mutch, and LL Spriet. Lack of effects of fish oil supplementation for 12 weeks on resting metabolic rate and substrate oxidation in healthy young men: A randomized controlled trial. PLoS One 12(2):e0172576, 2017. 

Whitfield, J, D Gamu, GJF Heigenhauser, LJC van Loon, LL Spriet, AR Tupling, and GP Holloway. Beetroot juice increases human muscle force without changing Ca2+-handling proteins. Med Sci Sports Exerc 49:2016-2024, 2017. 

Song, Z, DR Moore, N Hodson, C Ward, JR Dent, MF O’Leary, AM Shaw, DL Hamilton, S Sarkar, Y-L Gangloff, TA Hornberger, LL Spriet, GJ Heigenhauser, and A Philp. Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle. Sci Rep 7:5028, 2017. 

Whitfield, J, S Paglialunga, BK Smith, PM Miotto, G Simnett, HL Robson, SS Jain, EAF Herbst, EM Desjardins, DJ Dyck, LL Spriet, GR Steinberg, and GP Holloway. Ablating TBC1D1 impairs contraction-induced sarcolemmal glucose transporter type 4 redistribution, but not insulin-mediated responses in rats. J Biol Chem 292:16653-16664, 2017. 

Palmer, MS, GJF Heigenhauser, M Duong, and LL Spriet. Ingestion of a carbohydrate-electrolyte solution during simulated ice hockey exercise increases performance and glycogen use while minimizing perception of effort. Int J Sports Med 38:1061-1069, 2017.

Herbst EA, Paglialunga S, Gerling C, Whitfield J, Mukai K, Chabowski A, Heigenhauser GJ, Spriet LL, Holloway GP. Omega-3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle. J Physiol. 2014; 592(Pt 6):1341-52.

Logan SL, Gottlieb BH, Maitland SB, Meegan D, Spriet LL. The Physical Activity Scale for the Elderly (PASE) questionnaire; does it predict physical health? Int J Environ Res Public Health. 2013; 10(9):3967-86.

Zulyniak MA, Perreault M, Gerling C, Spriet LL, Mutch DM. Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men. Metabolism. 2013; 62(8):1107-13.

Logan-Sprenger HM, Heigenhauser GJ, Jones GL, Spriet LL. Increase in skeletal-muscle glycogenolysis and perceived exertion with progressive dehydration during cycling in hydrated men. Int J Sport Nutr Exerc Metab. 2013; 23(3):220-9.

Logan-Sprenger HM, Spriet LL. The acute effects of fluid intake on urine specific gravity and fluid retention in a mildly dehydrated state. J Strength Cond Res. 2013; 27(4):1002-8.

  • HK*3600 Applied Human Biology I 
  • KIN*4400 Independent Research in Kinesiology - Guelph-Humber
Name Role
D. McCarthy MSc Student
K. Wickham MSc Student
J. Pereira MSc Student

Dr. Spriet is no longer accepting applications from potential PhD Students. He will continue advising MSc Students.