Dr. Bruce J. Holub

University Professor Emeritus
Phone number: 
ext. 53743 (Office)
ANNU 243

I pursued graduate work at the University of Toronto with a major in biochemistry and minor in nutrition for the purpose of exploring how altering dietary fat types could alter biochemical pathways via various mechanisms with resulting benefits or detriments to human health.

My dissertation research was focused on the metabolism of essential fatty acids in vivo and their incorporation into membrane phospholipids. My post-doctoral work at the University of Michigan as supported by a MRC Fellowship allowed me to pursue studies on structure/functional relationships of polyunsaturated fatty acids in cellular systems. When I joined the Department of Nutrition (now Department of Human Health and Nutritional Sciences) at the University of Guelph, I focused my research on the potential benefits of omega-3 fatty acids from plant and fish sources with respect to cardiovascular health in humans including research on nutraceuticals/functional foods containing these fatty acids. As well, I have long studied the potential deleterious effects to human health of trans fatty acids found in processed and fast foods.

I have been most privileged to work with numerous dedicated and caring graduate students, research assistants, and collaborating colleagues from Canada and other countries during my research career. I have served as President of the Canadian Society for Nutritional Sciences and Chairman of the Nutrition Task Force for the Heart and Stroke Foundation of Ontario. I am also most appreciative of the awards granted to me including the Borden Award from the Nutrition Society of Canada, The McHenry Award from the Canadian Society for Nutritional Sciences, being elected a Fellow of the International Academy of Cardiovascular Sciences, the Gordin Kaplan award from the Canadian Federation of Biological Societies, and the 2006 Distinguished Nutrition Leadership Award from the Danone Institute at the Canadian Nutrition Congress in Winnipeg.

I have served on the editorial board of the Canadian Journal of Physiology and Pharmacology as well as Lipids.

For additional information, please refer to my website, or contact me via email at bholub@uoguelph.ca

B.Sc. - University of Guelph
M.Sc. - University of Toronto
Ph.D. - University of Toronto

Omega-3 fatty acids from fish, fish oils, and algal sources for human health and cardiovascular care. 'Trans' fatty acids and the risk of cardiovascular disease. Nutraceuticals and functional foods. Collaborative research with tribal fisheries and agri-food units on campus directed towards the development and human evaluation of nutritionally-enhanced and value-added animal products (omega-3 eggs, DHA-milk, etc.) and clinical studies on EPA/DHA concentrates in kidney patients on dialysis.

Forsyth S, Calder P, Zotor F, Amuna P, Meyer B, Holub B. Dietary DHA and arachidonic acid in early life - what is the best evidence for policy makers? Annals of Nutrition and Metabolism. 2018; in press.

Shaikh N, Yantha J, Shaikh S, Rowe W, Laidlaw M, Cockerline C, Ali A, Holub B, Jackowski G. Efficacy of a unique omega-3 formulation on the correction of nutritional deficiency and its effects on cardiovascular disease risk factors in a randomized controlled VASCAZEN(®) REVEAL Trial. Mol. Cell Biochem. 2014; 396: 9-22.

Holub B, Mutch DM, Pierce GN, Rodriguez-Leyva D, Aliani M, Innis S, Yan W, Lamarche B, Couture P, Ma DW. Proceedings from the 2013 Canadian Nutrition Society Conference on Advances in Dietary Fats and Nutrition. Appl. Physiol. Nutr. Metab. 2014; 39(7):754-762.

Moths MD, Dellinger JA, Holub B, Ripley MP, McGraw JE, Kinnunen RE. Omega-3 fatty acids in fish from the Laurentian Great Lakes Tribal Fisheries. J. Human and Ecological Risk Assessment. 2013; 19:1628-1643.

Ramadeen A, Connelly KA, Leong-Poi H, Hu X, Fujii H, Van Krieken R, Laurent G, Holub BJ, Bazinet RP, Dorian P. N-3 polyunsaturated fatty acid supplementation does not reduce vulnerability to atrial fibrillation in remodelling atria. Heart Rhythm. 2012; 9:1115-22.

Holub BJ, Swidinsky P, Park E. Oral Docosapentaenoic Acid (22:5 n-3) is Differentially Incorporated into Phospholipid Pools and Differentially Metabolized to Eicosapentanoic Acid in Tissues from Young Rats. Lipids. 2011; 46(5):399-407.

Rudkowska I, Ponton A, Jacques H, Lavigne C, Holub BJ, Marette A, Vohl MC. Effects of a Supplementation of n-3 Polyunsaturated Fatty Acids with or without Fish Gelatin on Gene Expression in Peripheral Blood Mononuclear Cells in Obese, Insulin-Resistant Subjects. Journal Nutrigenet. Nutrigenomics. 2011; 4(4):192-202.

O'Reilly E, Holub BJ, Laidlaw M, Garrioch C, Wlodek MG. Development of a standardized clinical protocol for ranking foods and meals based on postprandial triglyceride responses: The Lipemic Index. ISRN Vascular Medicine: 2011; Article ID 936974.

Rudkowska, I, Raymond C, Ponton A, Jacques H, Lavigne C, Holub BJ, Maretta A, Vohl MC. Validation of the Use of Peripheral Blood Mononuclear Cells as Surrogate Model for Skeletal Muscle Tissue in Nutrigenomic Studies. OMICS. 2011; 15(1-2):1-7.