We are interested in characterizing the mechanisms of pathogenesis, adaptation, and survival in fungal and bacterial microbes from a systems biology perspective through mass spectrometry-based quantitative proteomics. Specifically, research in the lab centres around the following areas:
- Differential patterns of pathogenic regulation between microbial species;
- Systems biology to elucidate microbial proteome dynamics and interactions;
- Mechanistic characterization of pathogenic proteins; and
- Mass spectrometry-based proteomics for drug discovery and repurposing.
Our long-term goals emphasize the utilization of mass spectrometry-based proteomics to fundamentally understand differential microbial adaptation and survival strategies and to integrate a novel systems biology platform for investigation of diverse biological systems, defining functional mechanisms of cellular regulation and pathogenesis.
Interested students and post-doctoral fellows are encouraged to contact me to learn more about new and exciting opportunities.