
Tremaine Visiting Speaker's Series with Dr. Jennifer Heemstra: Research Seminar
Research Seminar: “A chemical biology toolbox for probing A-to-I RNA editing.”
RNA undergoes extensive modification through enzymatic post-transcriptional editing events. Adenosine-to-inosine (A-to-I) editing is one of the most widespread and impactful of these modifications and is catalyzed by adenosine deaminases acting on RNA (ADARs). Resulting inosines base pair with cytosine, essentially re-coding adenosine sites to guanine. Editing is essential for a number of processes including embryogenesis, neurological function, and innate...