Graduate Defences


Graduate Defences


  • Boddington, Kelly - PHD.MCB - April 12, 2019
    (Advisor:  S. Graether)
    The role of a Vitis riparia dehydrin in protecting DNA from oxidative stress
  • Demelo, Mitchele - MSC.MCB - April 5, 2019
    (Advisor:  C. Khursigara)
    Identification of a novel interaction between cell division proteins FtsK and MinD in Eschericia coli
  • Tremblay, Olivier - MSC.MCB - March 29, 2019
    (Advisor:  R. Merrill)
    Vorin and Garvin are novel bacterial mono-ADP-ribosyltransferase toxins
  • Sandhu, Love - MSC.MCB - February 5, 2019
    (Advisor:  J. Dawson)
    Characterization of cardiac actin gene editing in zebrafish using CRISPR-Cas9 technology


  • Huszczynski, Steven - PHD.MCB - December 18, 2018
    (Advisors:  C. Khursigara and J. Lam)
    Genetic and biochemical characterization of the proteins that determine O-specific antigen chain length in Pseudomonas aeruginosa
  • Oliphant, Kaitlyn - PHD.MCB - December 17, 2018
    (Advisor:  E. Allen-Vercoe)
    Exploring the application of ecological theory to the human gut microbiota using complex defined microbial communities as models
  • Wood, Chantal - MSC.MCB - December 13, 2018
    (Advisor:  R. Merrill)
    Isolation and identification of natural product inhibitors of Plx2A, a toxin from Paenibacillus larvae
  • Drolet, Jennifer - MSC.MCB - December 10, 2018
    (Advisor:  S. Ryan)
    Investigating the omega-3 fatty acid DHA in acting as an exogenous regulator of the antioxidant response pathway in Parkinson’s disease
  • Kuc, Christopher - MSC.MCB - December 7, 2018
    (Advisor:  J. Vessey)
    Staufen 1 is dispensable for NPC self-renewal and neuronal differentiation but plays a role in anchoring NPCs to the ventricular zone during corticogenesis
  • Taylor, Tiegh - MSC.MCB - December 6, 2018
    (Advisor:  R. Lu)
    Luman potentially regulates whole-body metabolism through modulation of the hypothalamic-pituitary-adrenal axis
  • Aggett, Rebecca - MSC.MCB - December 5, 2018
    (Advisor:  S. Seah)
    Characterization of multifunctional enzyme complexes from Comamonas testosteroni KF1 and Thermomonospora curvata DSM43183 involved in steroid side chain degradation
  • Tyrawa, Caroline - MSC.MCB - December 4, 2018
    (Advisor:  G. van der Merwe)
    Demystifying Brettanomyces bruxellensis: Fermentation kinetics, flavourcompound production, and nutrient requirements during wort fermentation
  • Shaikh, Zeeshan - MSC.MCB - December 3, 2018
    (Advisor:  J. Dawson)
    Regulatory changes in the α-cardiac actin variants H88Y and F90Δ implicated in early-onset hypertrophic cardiomyopathy
  • Despond, Evan - MSC.MCB - November 27, 2018
    (Advisor: J. Dawson)
    The hypertrophic cardiomyopathy-linked α-cardiac actin variant A331P
  • Ralph, Robyn - MSC.MCB - November 23, 2018
    (Co-Advisors:  S. Wootton / P. Krell)
    Characterization of Autographa californica nucleopolyhedrovirus immediate early protein ME53: The role of conserved domains in BV production, viral gene transcription, and evidence for ME53 presence at the ribosome
  • Thorpe, Hayley - MSC.MCB+NEUR - November 19, 2018
    (Advisor:  J. Vessey)
    The RNA-binding protein hnRNP Q regulates dendritic morphogenesis and synapse number in cortical neurons
  • Timpano, Sara - PHD.MCB - November 16, 2018
    (Advisor:  J. Uniacke)
    An investigation of the molecular and cellular biology of human physioxic cell culture
  • Moore, Clayton - MSC.BINF - November 14, 2018
    (Advisor:  B. Meng)
    Prediction of the molecular boundary and evolutionary history of novel viral AlkB domains using homology modeling and principal component analysis
  • Evagelou, Sonia - MSC.MCB - November 5, 2018
    (Advisor:  J. Uniacke)
    Investigating the role of DDX28 as a novel regulator of the hypoxic cap-dependent translation initiation complex
  • Virta, Lilia - MSC.MCB - October 30, 2018
    (Advisor:  T. Akhtar)
    Polyisoprenoid alcohols influence plastidial membrane dynamics and photosynthetic performance in Solanum lycopersicum and Arabidopsis thaliana
  • El Osta, Lana - MSC.MCB - August 27, 2018
    (Co-advisors:  M. Kimber / J. Lam)
    Biochemical characterization of the putative glucosyltransferase, WapB, which acts on the uncapped core OS of P. aeruginosa
  • Cheng, Ashley - MSC.MCB - June 27, 2018
    (Advisor:  J.K. Yankulov)
    Evaluating the impact of replication fork pausing on epigenetic conversions in Saccharomyces cerevisiae:  A novel approach and first analysis
  • Pyc, Michal - PHD.MCB - June 18, 2018
    (Advisor:  R. Mullen)
    The dynamics of leaf lipid droplets and the identification of a novel lipid droplet protein in Arabidopsis thaliana
  • White, Jessica - MSC.MCB - May 11, 2018
    (Advisor:  I. Tetlow)
    Development and characterization of branching enzymes for improving industrial starches
  • Liston, Sean - PHD.MCB - April 30, 2018
    (Advisor:  C. Whitfield)
    Biosynthesis and Assembly of the Vi Antigen Capsule Produced by Salmonella enterica serovar Typhi
  • Anderson, Cole - MSC.MCB - April 19, 2018
    (Advisor:  J. Mathur)
    Investigating a role for phospholipids in plastid pleomorphy
  • Berezuk, Alison - PHD.MCB - March 27, 2018
    (Advisor:  C. Khursigara)
    Investigating the role of divisome protein FtsK as an essential checkpoint during bacterial cell division
  • Delfosse, Kathleen - MSC.MCB - March 19, 2018
    (Advisor:  J. Mathur)
    Investigations of the effects of subcellular sugar levels on plastid morphology
  • Patterson, Jenelle - PHD.MCB - February 26, 2018
    (Advisor:  M. Emes; Co-Advisor:  I. Tetlow)
    Post-translational regulation of Arabidopsis thaliana starch synthase 2
  • Sychantha, David - PHD.MCB - February 22, 2018
    (Advisor:  A. Clarke)
    O-Acetylation of Cell Wall Glycans in Gram-positive Bacteria
  • Smart, Anastasia - MSC.MCB+NEUR - January 26, 2018
    (Advisor:  J. Vessey)
    Characterizing the hnRNP Q complex and its activity in asymmetric neural precursor cell division during cerebral cortex development
  • Chuli, Kirsten - MSC.MCB - January 10, 2018
    (Advisor:  C. Khursigara)
    Examining the distribution of the extracellular polymeric substances in the biofilms of the Liverpool Epidemic Strain of Pseudomonas aeruginosa


  • Ryan, Patrick - MSC.MCB - December 20, 2017
    (Advisor:  M. Kimber)
    A molecular investigation of the interaction between Rubisco and beta-carboxysome interior organizer CcmM
  • Martin, Claire - PHD.MCB - December 13, 2017
    (Advisor:  N. Jones)
    Characterization of signaling pathways regulating nephrin endocytosis in kidney podocytes: novel roles for Nck and ShcA adaptor proteins
  • Gilbert, Stephanie - MSC.MCB - December 13, 2017
    (Advisor:  S. Seah)
    Characterization of an aldolase-hydratase complex found within the cholesterol degradation pathway of Mycobacterium tuberculosis
  • Humphries, Kayla - MSC.MCB - December 11, 2017
    (Advisor:  S. Ryan)
    A53T alpha-synuclein induces mitophagy through MAM-induced fission and reduced impairment of LC3B to promote alpha-synuclein degradation.
  • Dhavarasa, Piriththiv - MSC.MCB - December 6, 2017
    (Advisor:  J. Yankulov)
    Mechanistic Understanding Of PCNA-based Interactions: The Interplay Between CAF-I and Rrm3p for the DNA Sliding Clamp PCNA
  • Ciufo, Joseph - MSC.MCB - November 30, 2017
    (Advisor:  A. Clarke)
    Inhibition of membrane-bound lytic transglycosylases A, B and F by membrane-bound lysozyme inhibitor of C-type lysozyme
  • Van Loggerenberg, Warren - PHD.MCB - November 24, 2017
    (Advisors:  N. Nazar / S. Seah)
    Functional significance of structural features and intermediate cleavages in the 5’ ETS of the Schizosaccharomyces pombe pre-rRNA
  • Wang, You - PHD.MCB - November 3, 2017 (note Room change)
    (Advisors:  M. Emes / I. Tetlow)
    The role of SNF1-related protein kinase 1 (SnRK1) in regulating intermediary metabolism in Arabidopsis thaliana
  • Rea, Kevin - MSC.MCB - September 15, 2017
    (Advisor:  T. Akhtar)
    Multifaceted in vivo and in vitro characterization of cis-prenyltransferase 5 from Solanum lycopersicum
  • Mahesaniya, Afreeda - MSC.MCB - September 12, 2017
    (Advisor:  N. Jones)
    Investigating the effects of soy (phyto)estrogens on the Akt podocyte survival signaling pathway
  • Palmer, Sharall - MSC.MCB - September 11, 2017
    (Advisor:  S. Graether)
    The role of residue position and charge in the cryoprotective behaviour of the Vitis riparia K2 and YSK2 dehydrins
  • Nasanovsky, Liliya - PHD.MCB - September 1, 2017
    (Advisor:  I. Tetlow)
    Bacterial branching enzymes as agents for modifying glucan structure in industrial processing
  • Hillier, Dendra - MSC.MCB - August 23, 2017
    (Advisor:  J. Vessey)
    Investigating the role of hnRNP-M in asymmetric neural precursor cell divisions in the developing cerebral cortex
  • Verzijlenberg, Lisette - MSC.MCB - August 23, 2017
    (Advisor:  D. Mosser)
    Effect of hyperthermia and HSP70 protein overexpression on FOXO3a levels in acute lymphoblastic T-cells
  • Malik, Wadood - MSC.MCB - August 17, 2017
    (Advisor:  A. Bendall)
    Novel tools for Dlx5 and Dlx6 knockdown in the chicken embryo
  • Marroushi, Ziad - MSC.MCB - August 1, 2017
    (Advisor:  L. Mutharia)
    Functional analysis of nucleoside diphosphate kinase from Mycobacterium avium subspecies paratuberculosis
  • Lyons, Bronwyn - MSC.MCB - July 26, 2017
    (Advisor:  R. Merrill)
    A kinetic and structure-guided characterization of Scabin, a novel mono-ADP-ribosyltransferase produced by Streptomyces scabies
  • Penney, Jenna - PHD.MCB+NEUR - July 13, 2017
    (Advisor:  R. Lu)
    Characterization of the potential role of Luman as a novel regulator of animal stress responses
  • Kelly, Nicole - MSC.MCB - July 11, 2017
    (Advisor:  J. Uniacke)
    Hypoxia activates cadherin-22 synthesis via eIF4E2 to drive the migration, invasion and adhesion of breast cancer and glioma cells
  • Preiss, Richard - MSC.MCB - April 26, 2017
    (Advisor:  G. Van der Merwe)
    Autophagy Gene Overexpression in Saccharomyces cerevisiae for Accelerated Sparkling Wine Production
  • Stirling, Alexander - MSC.MCB - March 30, 2017
    (Advisor:  S. Seah)
    Structure-Function Studies of Acyl-CoA Dehydrogenases Involved in Steroid Degradation
  • Hooker, Julia - MSC.MCB - March 14, 2017
    (Advisor:  B. Meng)
    Analysis of the genetic diversity of Grapevine rupestris stem pitting-associated virus in Ontarian vineyards and construction of a full-length infectious clone
  • Carlucci, Christian - PHD.MCB - March 2, 2017
    (Advisor: E. Allen-Vercoe)
    Examining the effects of defined microbial ecosystems on Clostridioides difficile growth and virulence 

  • Herlihey, Francesca - PHD.MCB - January 24, 2017
    (Advisor: A. Clarke)
    Biochemical Characterization of the Activity and Control of the Autolysins Involved in Flagella Assembly in Gram-Negative Bacteria 

  • Liu, Haidun - MSC.MCB - January 20, 2017
    (Advisor: J. Dawson)
    How do regulated thin filaments with hypertrophic cardiomyopathy-linked α-cardiac actin affect actomyosin interactions? 

  • Secord, Nathaniel - MSC.MCB - January 12, 2017
    (Advisor: S. Rothstein)
    Exploring the potential of AtENOD93 and A. thaliana as a model system to study ENOD93-like proteins


  • Coumoundouros, Chelsea - MSC.MCB - November 29, 2016
    (Advisor: J. Wood)
    Investigating the Oligomeric State of Osmoregulatory Transporter ProP of Escherichia coli and its Functional Consequences
  • Watt, Samantha - MSC.MCB - October 18, 2016
    (Advisor: R. Mullen)
    Arabidopsis AT3G11620 is an evolutionarily conserved protein involved in facilitating the intracellular distribution of lipid droplets
  • Poole, Amanda - MSC.MCB - September 13, 2016
    (Advisor: R. Merrill)
    Kinetic characterization of VopT, a mono-ADP-ribosyltransferase toxin from Vibrio parahaemolyticus
  • Varga, Joseph - MSC.MCB - August 31, 2016
    (Advisor: J. Uniacke)
    Cancer cells exploit eIF4E2-directed translation to enhance their proliferation, migration and invasion
  • Charles, Sherise - MSC.MCB - August 30, 2016
    (Advisor: C. Khursigara)
    The proteomic response of the probiotic Pediococcus acidilactici R1001 after exposure to the cell-free supernatant of the pathogen Listeria monocytogenes ATCC 7644
  • McNeilly, Rachael - MSC.MCB - August 23, 2016
    (Advisor: N. Jones)
    Investigating intracellular SNARE-mediated trafficking of the kidney slit diaphragm protein nephrin
  • Weiss, Alexander - MSC.MCB - August 22, 2016
    (Advisor: T. Van Raay)
    Defining Wnt activity and Nkd1 function in mammalian cell lines IEC-18 and HEK293
  • Reynolds, Kathryn - MSC.MCB - August 19, 2016
    (Advisor: J. Vessey)
    The RNA-binding protein Musashi2 regulates asymmetric neural precursor cell divisions of the developing cerebral cortex
  • Gonzalez, Karen - MSC.MCB - June 22, 2016
    (Advisor: J. Wood)
    The Impacts of ProP putative interactors on the localization and activity of the transporter ProP, and on Escherichia coli phenotype
  • Abbasi, Sanna - MSC.MCB - June 7, 2016
    (Advisor: J. Yankulov)
    The impact of subtelomeric DNA on epigenetic switching in Saccharomyces cerevisiae
  • Martin, Will - MSC.MCB - May 31, 2016
    (Advisor: L. Mutharia)
    The isolation and proteomic analysis of Mycobacterium avium subspecies paratuberculosis secreted membrane vesicles 
  • Xu, Zhenhua - PHD.MCB - May 16, 2016
    (Advisor: S. Rothstein)
    The role of anthocyanins and the GATA transcription factors GNC and CGA1 in the plant response to stress
  • Mazurkewich, Scott - PHD.MCB - May 4, 2016
    (Advisor: S. Seah)
    Characterization of the 4-carboxy-2-hydroxymuconate hydratase and the 4-carboxy-4-hydroxy-2-oxoadipate / 4-hydroxy-4-methyl-2-oxoglutarate aldolase from Pseudomonas putida
  • Carlow, Chevonne - PHD.MCB - April 28, 2016
    (Advisor: A. Nassuth)
    Analysis of the Vitis CBF genes and their potential roles in the both the CBF and stomatal development pathways
  • Mundia, Maureen - PHD.MCB - April 27, 2016
    (Advisor: M. Baker)
    Analysis of the genetic requirements for Rad51-mediated 3' polymerization during DNA repair by homologous recombination
  • Albeely (Mohamed), Abdalla - MSC.MCB - April 26, 2016
    (Co-Advisors: R. Nazar/A.Bendall)
    Termination of Ribosomal RNA Transcript by RNA polymerase I in Schizosaccharomyces pombe
  • Wills, Melanie - PHD.MCB - April 12, 2016
    (Advisor: N. Jones)
    Decoding Shc deviance: Evidence of novel roles for the phosphotyrosine adaptor ShcD in Epidermal Growth Factor Receptor (EGFR) signalling and dynamics
  • Faultless, JW Trent - MSC.MCB - April 7, 2016
    (Advisor: A. Nassuth)
    Protein domains of Vitis CBF1 and translational regulation of cold-induced genes via codon usage
  • Castroverde, Christian Danve M. - PHD.MCB - March 31, 2016
    (Advisors: J. Mathur and J. Robb)
    Molecular biology of the tomato Ve gene family
  • Cochrane, Kyla - PHD.MCB - February 26, 2016
    (Advisor: E. Allen-Vercoe)
    Elucidating potential virulence factors in Fusobacterium nucleatum
  • Taylor, Véronique - PHD.MCB - February 19, 2016
    (Advisor: J. Lam)
    Molecular and biochemical investigation of mechanisms that propel O-antigen diversity in Pseudomonas aeruginosa
  • Blake, Katherine - MSC.MCB - January 28, 2016
    (Advisors: J. Uniacke and G. Bag)
    An investigation of the non-redundant functions of PABPC4 via protein-protein interactions and PABP-depletion studies
  • Pasula, Daniel - MSC.MCB - January 6, 2016
    (Advisor: T. Van Raay)
    Investigating the role of Axin2 in the regulation of the Wnt signaling pathway in early zebrafish development
  • Udaskin, Molly - MSC.MCB - January 5, 2016
    (Advisor: B. Meng)
    Investigation into the proteolytic processing and localization of the replicase polyprotein of Grapevine rupestris stem pitting-associated virus


  • Kell, Elisabeth - MSC.MCB - December 22, 2015
    (Advisor: C. Whitfield)
    Characterizing properties of bacterial outer membrane polysaccharide export (OPX) proteins
  • Toh, Michael - PHD.MCB - December 10, 2015
    (Advisor: E. Allen-Vercoe / T. VanRaay)
    Zebrafish as a novel animal model for evaluating the human gastrointestinal microbiota in autism spectrum disorder
  • Wozny, Michael - MSC.MCB - December 9, 2015
    (Advisor: J. Mathur)
    Subcellular responses to phosphate limited and sucrose replete conditions in plant cells
  • Martynowicz, David - MSC.MCB - December 8, 2015
    (Advisor: M. Coppolino)
    Analysis of Munc18c and Syntaxin4 function during tumour cell invasion
  • Wroblewski, Charles - MSC.MCB - December 7, 2015
    (Advisor: M. Kimber)
    Characterization of the interactions between CcmM and Rubisco – key players in organizing the β-carboxysome interior
  • Kell, Laura - MSC.MCB - December 4, 2015
    (Advisor: A. Clarke)
    Characterization and investigation of novel inhibitory compounds of O-acetyltransferase A (OatA) from Staphylococcus aureus
  • Wyse, Brandon - MSC.MCB - November 27, 2015
    (Advisor: K. Yankulov)
    Epigenetic inheritance in Saccharomyces cerevisiae: the competition between CAF-I and Rrm3p for the DNA sliding clamp PCNA
  • Pasman, Yfke - PHD.MCB - November 17, 2015
    (Advisor: A. Kaushik)
    Bovine antibody genetics, structure and antigenization for disease prevention
  • Lockhart, Morgan - MSC.MCB - October 30, 2015
    (Advisor: S.Rothstein)
    An investigation of the role of stress-responsive aldo-keto reductases in Arabidopsis thaliana
  • Ecclestone, Mark - MSC.MCB - October 8, 2015
    (Advisor: A. Clarke)
    Investigation of protein and inhibitor binding to O-Acetylpeptidoglycan esterase 1 from Neisseria gonorrhoeae
  • Facciuolo, Antonio - PHD.MCB - September 24, 2015
    (Advisor: L. Mutharia)
    Proteomic and immunological investigation of Mycobacterium avium subspecies paratuberculosis secreted proteins
  • Roach, Elyse - PHD.MCB - September 18, 2015
    (Advisor: C. Khursigara)
    Investigation of the structures of ZapA and ZapD from Escherichia coli and their roles in bacterial cell division
  • Deol, Reema - MSC.MCB.TOX - September 4, 2015
    (Advisor: D. Josephy)
    Substrate specificity of human N-acetyltransferase 8 for aromatic cysteine conjugates
  • Jaipargas, Erica Ashley - MSC.MCB - August 18, 2015
    (Advisor: J. Mathur)
    Investigations on mitochondria pleomorphy and interactions with the endoplasmic reticulum and peroxisomes
  • Liu, Yang - PHD.MCB - July 10, 2015
    (Co-Advisors: P. Krell / É. Nagy)
    Functional analysis of the baculovirus AcMNPV me53/ME53
  • Marom, David - MSC.MCB - May 4, 2015
    (Advisor: J. Wood)
    The role of the C-terminal coiled-coil in the cellular localization and in the osmotic stress response of transporter ProP
  • Roufayel, Rabih - PHD.MCB - April 30, 2015
    (Advisor: D. Mosser)
    Regulation of heat-induced apoptosis by the loss of miR-23a-dependent control of NOXA in human cells and its suppression by HSP70 
  • Meeks, Tylar - MSC.MCB - April 29, 2015
    (Advisor: J. Colasanti)
    Investigating the Function of the Arabidopsis thaliana INDETERMINATE DOMAIN2 gene
  • Bertin, David - MSC.MCB - April 29, 2015
    (Advisor: R. Lu)
    Potential new aging model Schmidtea mediterranea undergoes gradual senescence and experiences accelerated senescence at elevated temperature
  • Bolte, Erin - MSC.MCB - April 29, 2015
    (Advisor: E. Allen-Vercoe)
    Characterization of the Human Gut Microbiota Metabolite Profile in Autism Spectrum Disorder
  • Anillo, Maria - MSC.MCB - April 27, 2015
    (Advisor: J. Dawson)
    Hypertrophic cardiomyopathy-linked α-cardiac actin mutations and their role on actomyosin interactions
  • Zhao, Qianru (Ruby) - PHD.MCB - April 24, 2015
    (Advisor: M. Emes)
    Regulation of starch biosynthesis in Arabidopsis thaliana
  • Jenkins, Andrew - MSC.MCB - April 23, 2015
    (Advisor: G. Harauz)
    Conformational transitions of 18.5-kDa myelin basic protein studied by fluorescence spectroscopy and Förster resonance energy transfer
  • Hoang, Tuan - PHD.BIG - April 21, 2015
    (Co-Advisors: M. Jelokhani-Niaraki, WLU and R. Merrill)
    Exploring the structure and function of human uncoupling proteins: A biophysical approach
  • Fletcher, Andrew - MSC.BINF - April 16, 2015
    (Advisor: G. van der Merwe)
    Microarray analysis of DV10 Saccharomyces cerevisiae during second fermentation under oenological conditions
  • Clarke, Matt - MSC.MCB - January 16, 2015
    (Advisor: S. Graether)
    The K2 Dehydrin: an intrinsically disordered membrane protector
  • Rahman, Mohammad Atikur - PHD.MCB - January 9, 2015
    (Advisor: A. Nassuth)
    Role of ice proteins in freezing tolerance and stomatal development in grapes
  • Mishra, Vadika - MSC.MCB - January 8, 2015
    (Advisor: J. Dawson)
    Characterization of short ADP ribosylated oligomers developed by modification in F-actin structure
  • Teresinski, Howard - MSC.MCB - January 7, 2015
    (Advisor: R. Mullen)
    Distinct C-terminal amino acid sequence motifs serve as the targeting signals for outer mitochondrial membrane and plastid outer envelope TA proteins
  • Samson, Jonathan - MSC.MCB - January 6, 2015
    (Advisor: A. Clarke)
    Elucidating the enzymatic function of resuscitation promoting factor B, RpfB, from Mycobacterium tuberculosis