Drugs of abuse have the capacity to alter behaviors and shift priorities. Research conducted in the Addiction, Interoception, and Motivation Laboratory broadly revolves around investigating how these effects emerge. This work extends to pharmacological and psychological interventions with the purpose of promoting rehabilitation of compulsive drug-seeking behaviors.
Undergraduate (1998-2003): BS - Psychology - University of Nebraska-Kearney, Kearney NE, USA
Graduate (2004-2009): PhD - Biopsychology - University of Nebraska-Lincoln, Lincoln NE, USA
Post Doctoral (2009-2016): Behavioural Neuroscience - University of Cambridge, Cambridge UK
Research Assistant Professor (2016-2017): Department of Psychology, University of Nebraska-Lincoln, Lincoln NE, USA
2019-2024 NSERC DG: Manipulating the nature of internal stimuli through conditioning.
The purpose of this research program is to determine the behavioural and neural mechanisms of how an appetitive versus an aversive learning history with a perceptible drug state alters the value of that drug.
2019-2021 NIDA R03: Impact of adding tobacco constituents nornicotine and anatabine on self-administered nicotine.
The purpose of this research program is to determine the altered susceptibility to tobacco following nicotine consumption in adolescents or adults.
2019 CFI JELF: Impact of learning history on individual susceptibility to developing an addiction phenotype.
This grant provides the infrastructure required to measure and manipulate neurochemical correlates of compulsive drug-seeking behaviours.
(* indicates graduate student contribution; ** indicates undergraduate student contribution)
Renda B*, Andrade AK*, Stone APS**, El Azali R**, Sharivker M**, Khokhar JY, Antenos M, Murray JE (in press) Adolescent nicotine and footshock exposure augments adult nicotine self-administration and drug-seeking without affecting baseline anxiety-like behaviour or stress responsivity in male rats. Psychopharmacology
Renda B*, Andrade AK*, Frie JA, Sgarbossa CL**, Murray JE, Khokhar JY (2020) High-dose adolescent nicotine exposure permits spontaneous nicotine self-administration in adult male rats. Drug and Alcohol Dependence, 215, 108215.
Huynh YW, Thompson BM, Larsen CE, Buch S, Guo M-L, Bevins RA, Murray JE (2020) Male HIV-1 transgenic rats show reduced cocaine-maintained lever-pressing compared to F344 wildtype rats despite similar baseline locomotion. Journal of the Experimental Analysis of Behavior, 113:468-484.
Andrade AK*, Renda B*, Murray JE (2019) Cannabinoids, interoception, and anxiety. Pharmacology, Biochemistry and Behavior, 180:60-73.
Hodebourg R, Murray JE, Fouyssac M, Puaud M, Everitt BJ, Belin D (2018) Heroin seeking becomes dependent on dorsal striatal dopaminergic mechanisms and can be decreased by N-acetylcysteine. European Journal of Neuroscience.
Murray JE, Barrett ST, Brock R, Bevins RA (2017) Caring about power analyses. ACS Chemical Neuroscience, 8:2352-2354.
Jupp B, Murray JE, Jordan ER, Xia J, Fluharty M, Shrestha S, Robbins TW, Dalley JW (2016) Social dominance in rats predicts cocaine self-administration, novelty reactivity and altered dopamine receptor binding and content in the striatum. Psychopharmacology, 233:579-589.
Murray JE, Belin-Rauscent A, Simon M, Giuliano C, Benoît-Marand M, Everitt BJ, Belin D (2015) Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits. Nature Communications, 6:10088.
Murray JE, Dilleen RM, Pelloux Y, Economidou D, Dalley JW, Belin D, Everitt BJ (2014) Increased impulsivity retards the transition to dorsolateral striatal dopamine control of cocaine seeking. Biological Psychiatry, 76:15-22.
Pelloux Y, Murray JE, Everitt BJ (2013) Differential roles of the prefrontal cortical subregions and basolateral amygdala in compulsive cocaine seeking and relapse after voluntary abstinence in rats. European Journal of Neuroscience, 38:3018-3026.
Murray JE, Belin D, Everitt BJ (2012) Double dissociation of the dorsomedial and dorsolateral striatal control over the acquisition and performance of cocaine seeking. Neuropsychopharmacology, 37:2456-2466.
Murray JE, Everitt BJ, Belin D (2012) N-Acetylcysteine reduces early and late-stage cocaine seeking without affecting cocaine taking in rats. Addiction Biology, 17:437-440.
Murray JE, Walker AW, Polewan RJ, Bevins RA (2011) An examination of NMDA receptor contribution to conditioned responding evoked by the conditional stimulus effects of nicotine. Psychopharmacology, 213:131-141.
Murray JE, Wells NR, Bevins RA (2011) Nicotine competes with a visual stimulus for control of conditioned responding. Addiction Biology, 16:152-162.
Murray JE, Bevins RA (2010) Cannabinoid conditioned reward and aversion: behavioral and neural processes. ACS Chemical Neuroscience, 1:265-278.
Murray JE, Bevins RA (2009) Acquired appetitive responding to intravenous nicotine reflects a Pavlovian conditioned association. Behavioral Neuroscience, 123:97-108.
Murray JE, Wells NR, Lyford GD, Bevins RA (2009) Investigation of endocannabinoid modulation of conditioned responding evoked by a nicotine CS and the Pavlovian stimulus effects of CP 55,940 in adult male rats. Psychopharmacology, 205:655-665.
Reichel CM, Murray JE, Grant KM, Bevins RA. (2009) Bupropion attenuates methamphetamine self-administration in adult male rats. Drug and Alcohol Dependence, 100:52-62.
Murray JE, Bevins RA (2007) Behavioral and neuropharmacological characterization of nicotine as a conditional stimulus. European Journal of Pharmacology, 561:91-104.
PSYC*4750 - Seminar in Motivation and Emotion
NEUR*2000 - Introduction to Neuroscience
PSYC*2330 - Principles of Learning
NEUR*3500 - Techniques in Neuroscience
NEUR*6100 - Collaborative Neuroscience Seminar Series
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