Drugs of abuse have the capacity to alter behaviors and shift priorities. Research conducted in the Addiction, Interoception, and Motivation Laboratory broadly revolves around investigating how these effects emerge. This work extends to pharmacological and psychological interventions with the purpose of promoting rehabilitation of compulsive drug-seeking behaviors.
Undergraduate (1998-2003): BS - Psychology - University of Nebraska-Kearney, Kearney NE, USA
Graduate (2004-2009): PhD - Biopsychology - University of Nebraska-Lincoln, Lincoln NE, USA
Post Doctoral (2009-2016): Behavioural Neuroscience - University of Cambridge, Cambridge UK
Research Assistant Professor (2016-2017): Department of Psychology, University of Nebraska-Lincoln, Lincoln NE, USA
2019-2024 NSERC DG: Manipulating the nature of internal stimuli through conditioning.
The purpose of this research program is to determine the behavioural and neural mechanisms of how an appetitive versus an aversive learning history with a perceptible drug state alters the value of that drug.
(* indicates graduate student contribution; 1 indicates shared 1st authorship)
Andrade AK*, Renda B*, Murray JE (2019) Cannabinoids, interoception, and anxiety. Pharmacology, Biochemistry and Behavior, 180:60-73.
Hodebourg R1, Murray JE1, Fouyssac M, Puaud M, Everitt BJ, Belin D (2018) Heroin seeking becomes dependent on dorsal striatal dopaminergic mechanisms and can be decreased by N-acetylcysteine. European Journal of Neuroscience.
Murray JE, Barrett ST, Brock R, Bevins RA (2017) Caring about power analyses. ACS Chemical Neuroscience, 8:2352-2354.
Jupp B1, Murray JE1, Jordan ER1, Xia J, Fluharty M, Shrestha S, Robbins TW, Dalley JW (2016) Social dominance in rats predicts cocaine self-administration, novelty reactivity and altered dopamine receptor binding and content in the striatum. Psychopharmacology, 233:579-589.
Murray JE1, Belin-Rauscent A1, Simon M, Giuliano C, Benoît-Marand M, Everitt BJ, Belin D (2015) Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits. Nature Communications, 6:10088.
Murray JE, Dilleen RM, Pelloux Y, Economidou D, Dalley JW, Belin D, Everitt BJ (2014) Increased impulsivity retards the transition to dorsolateral striatal dopamine control of cocaine seeking. Biological Psychiatry, 76:15-22.
Pelloux Y, Murray JE, Everitt BJ (2013) Differential roles of the prefrontal cortical subregions and basolateral amygdala in compulsive cocaine seeking and relapse after voluntary abstinence in rats. European Journal of Neuroscience, 38:3018-3026.
Murray JE, Belin D, Everitt BJ (2012) Double dissociation of the dorsomedial and dorsolateral striatal control over the acquisition and performance of cocaine seeking. Neuropsychopharmacology, 37:2456-2466.
Murray JE, Everitt BJ, Belin D (2012) N-Acetylcysteine reduces early and late-stage cocaine seeking without affecting cocaine taking in rats. Addiction Biology, 17:437-440.
Murray JE, Walker AW, Polewan RJ, Bevins RA (2011) An examination of NMDA receptor contribution to conditioned responding evoked by the conditional stimulus effects of nicotine. Psychopharmacology, 213:131-141.
Murray JE, Wells NR, Bevins RA (2011) Nicotine competes with a visual stimulus for control of conditioned responding. Addiction Biology, 16:152-162.
Murray JE, Bevins RA (2010) Cannabinoid conditioned reward and aversion: behavioral and neural processes. ACS Chemical Neuroscience, 1:265-278.
Murray JE, Bevins RA (2009) Acquired appetitive responding to intravenous nicotine reflects a Pavlovian conditioned association. Behavioral Neuroscience, 123:97-108.
Murray JE, Wells NR, Lyford GD, Bevins RA (2009) Investigation of endocannabinoid modulation of conditioned responding evoked by a nicotine CS and the Pavlovian stimulus effects of CP 55,940 in adult male rats. Psychopharmacology, 205:655-665.
Reichel CM, Murray JE, Grant KM, Bevins RA. (2009) Bupropion attenuates methamphetamine self-administration in adult male rats. Drug and Alcohol Dependence, 100:52-62.
Murray JE, Bevins RA (2007) Behavioral and neuropharmacological characterization of nicotine as a conditional stimulus. European Journal of Pharmacology, 561:91-104.
PSYC*4750 - Seminar in Motivation and Emotion
NEUR*2000 - Introduction to Neuroscience
PSYC*2330 - Principles of Learning
NEUR*3500 - Techniques in Neuroscience